Proactive Resilience Building through Route Diversity: A Close Look at the Metro System from the Travelers’ Perspective

Travel demand plays a moderate role in the resilience impact assessment of public transport network disruptions. We analyze how travelers can proactively build transport resilience by responding to adverse events using alternative routes. We consider route diversity (i.e., the numbers of alternative routes for all origin–destination (OD) pairs) as a measure of the network’s capability to accommodate route choice behavioral change and look for potential proactive travelers from the spatial distribution of OD pairs with alternative routes in the Beijing subway network. We further investigate how proactive resilience can be built by choosing alternative routes with the least extra time cost

Drawing metro maps in concentric circles: A designer‐in‐the‐loop approach with visual examples

This article presents a proof-of-concept designer-in-the-loop schematic map drawing tool, based on the marriage of two approaches—manual and automated, which provides the technical interactivity of drawing tools between the user and the computer. We focus on concentric circle maps as opposed to the commonly used orthogonal mode representation, which is suggested by previous studies that it could promote better network learning. In comparison with existing methods, the proposed method is more compatible with the framework of effective map design from psychological and aesthetic perspectives, and a range of options can be provided in conjunction with users' preferences. We evaluated our approach on a set of iterations with case studies of Hong Kong metro with a group of three co-authors from the fields of geography, transport engineering, and education

Dietary Supplementation of Astaxanthin Improved the Growth Performance, Antioxidant Ability and Immune Response of Juvenile Largemouth Bass (Micropterus salmoides) Fed High-Fat Diet

High-fat diet (HFD) usually induces oxidative stress and astaxanthin is regarded as an excellent anti-oxidant. An 8-week feeding trial was conducted to investigate the effects of dietary astaxanthin supplementation on growth performance, lipid metabolism, antioxidant ability, and immune response of juvenile largemouth bass (Micropterus salmoides) fed HFD. Four diets were formulated: the control diet (10.87% lipid, C), high-fat diet (18.08% lipid, HF), and HF diet supplemented with 75 and 150 mg kg−1 astaxanthin (HFA1 and HFA2, respectively). Dietary supplementation of astaxanthin improved the growth of fish fed HFD, also decreased hepatosomatic index and intraperitoneal fat ratio of fish fed HFD, while having no effect on body fat. Malondialdehyde content and superoxide dismutase activity were increased in fish fed HFD, astaxanthin supplementation in HFD decreased the oxidative stress of fish. The supplementation of astaxanthin in HFD also reduced the mRNA levels of Caspase 3, Caspase 9, BAD, and IL15. These results suggested that dietary astaxanthin supplementation in HFD improved the growth performance, antioxidant ability and immune response of largemouth bass.publishedVersio

New testing and calculation method for determination viscoelasticity of optical glass

Viscoelastic properties of glass within molding temperatures, such as shear relaxation modulus and bulk relaxation modulus, are key factors to build successful numerical model, predict forming process, and determine optimal process parameters for precision glass molding. However, traditional uniaxial compression creep tests with large strains are very limited in obtaining high-accuracy viscoelastic data of glass, due to the declining compressive stress caused by the increasing cross-sectional area of specimen in testing process. Besides, existing calculation method has limitation in transforming creep data to viscoelasticity data, especially when Poisson's ratio is unknown at molding temperature, which further induces a block to characterize viscoelastic parameter. This study proposes a systematic acquisition method tbr high-precision viscoelastic data, including creep testing, viscoelasticity calculation, and finite element verification. A minimal uniaxial creep testing (MUCT) method based on thermo-mechanical analysis (TMA) instrument is first built to obtain ideal and accurate creep data, by keeping compressive stress as a constant. A new calculation method on viscoelasticity determination is then proposed to derive shear relaxation modulus without the need of knowing bulk modulus or Poisson's ratio, which, compared with traditional method, extends the application range of viscoelasticity calculation. After determination, the obtained viscoelastic data are further incorporated into a numerical simulation model of MUCT to verify the accuracy of the determined viscoelasticity. Base on the great consistence between simulated and measured results (uniaxial creep displacement), the proposed systematic acquisition method can be used as a high accuracy viscoelasticity determination method.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Isolation and screening of a chitin deacetylase producing Bacillus cereus and its potential for chitosan preparation

Chitosan is a biopolymer material extracted from marine biomass waste such as shrimp and crab shells, which has good biocompatibility and degradability with great potential for application in the field of wastewater treatment and soil remediation. The higher the degree of deacetylation (DD), the better the adsorption performance of chitosan. Chitin deacetylase (CDA) can specifically catalyze the deacetylate of chitin in a green reaction that is environmentally friendly. However, the scarcity of high yielding chitin deacetylase strains has been regarded as the technical bottleneck of chitosan green production. Here, we screened a natural chitin degrading bacterium from coastal mud and identified it as Bacillus cereus ZWT-08 by re-screening the chitin deacetylase activity and degree of deacetylation values. By optimizing the medium conditions and enzyme production process, ZWT-08 was cultured in fermentation medium with 1% (m/V) glucose and yeast extract at pH 6.0, 37°C, and a stirring speed of 180 r/min. After fermenting in 5 L fermenter for 48 h, the deacetylation activity of the supernatant reached 613.25 U/mL. Electron microscopic examination of the chitin substrate in the fermentation medium revealed a marshmallow-like fluffy texture on its structural surface. Meanwhile, 89.29% of the acetyl groups in this chitin substrate were removed by enzymatic digestion of chitin deacetylase produced by ZWT-08, resulting in the preparation of chitosan a degree of deacetylation higher than 90%. As an effective strain for chitosan production, Bacillus cereus ZWT-08 plays a positive role in the bioconversion of chitin and the upgrading of the chitosan industry

Prognostic value of the neutrophil to lymphocyte ratio in lung cancer: A meta-analysis

Recently, a series of studies explored the correlation between the neutrophil to lymphocyte ratio and the prognosis of lung cancer. However, the current opinion regarding the prognostic role of the neutrophil to lymphocyte ratio in lung cancer is inconsistent. We performed a meta-analysis of published articles to investigate the prognostic value of the neutrophil to lymphocyte ratio in lung cancer. The hazard ratio (HR) and its 95% confidence interval (CI) were calculated. An elevated neutrophil to lymphocyte ratio predicted worse overall survival, with a pooled HR of 1.243 (95%CI: 1.106-1.397; Pheterogeneity=0.001) from multivariate studies and 1.867 (95%CI: 1.487-2.344; Pheterogeneity=0.047) from univariate studies. Subgroup analysis showed that a high neutrophil to lymphocyte ratio yielded worse overall survival in non-small cell lung cancer (NSCLC) (HR=1.192, 95%CI: 1.061-1.399; Pheterogeneity=0.003) as well as small cell lung cancer (SCLC) (HR=1.550, 95% CI: 1.156-2.077; Pheterogeneity=0.625) in multivariate studies. The synthesized evidence from this meta-analysis of published articles demonstrated that an elevated neutrophil to lymphocyte ratio was a predictor of poor overall survival in patients with lung cancer

UniFuzz: Optimizing Distributed Fuzzing via Dynamic Centralized Task Scheduling

Fuzzing is one of the most efficient technology for vulnerability detection. Since the fuzzing process is computing-intensive and the performance improved by algorithm optimization is limited, recent research seeks to improve fuzzing performance by utilizing parallel computing. However, parallel fuzzing has to overcome challenges such as task conflicts, scalability in a distributed environment, synchronization overhead, and workload imbalance. In this paper, we design and implement UniFuzz, a distributed fuzzing optimization based on a dynamic centralized task scheduling. UniFuzz evaluates and distributes seeds in a centralized manner to avoid task conflicts. It uses a "request-response" scheme to dynamically distribute fuzzing tasks, which avoids workload imbalance. Besides, UniFuzz can adaptively switch the role of computing cores between evaluating, and fuzzing, which avoids the potential bottleneck of seed evaluation. To improve synchronization efficiency, UniFuzz shares different fuzzing information in a different way according to their characteristics, and the average overhead of synchronization is only about 0.4\%. We evaluated UniFuzz with real-world programs, and the results show that UniFuzz outperforms state-of-the-art tools, such as AFL, PAFL and EnFuzz. Most importantly, the experiment reveals a counter-intuitive result that parallel fuzzing can achieve a super-linear acceleration to the single-core fuzzing. We made a detailed explanation and proved it with additional experiments. UniFuzz also discovered 16 real-world vulnerabilities.Comment: 14 pages, 4 figure

Exosome and virus infection

Exosomes are messengers of intercellular communication in monolayer vesicles derived from cells. It affects the pathophysiological process of the body in various diseases, such as tumors, inflammation, and infection. It has been confirmed that exosomes are similar to viruses in biogenesis, and exosome cargo is widely involved in many viruses’ replication, transmission, and infection. Simultaneously, virus-associated exosomes can promote immune escape and activate the antiviral immune response of the body, which bidirectionally modulates the immune response. This review focuses on the role of exosomes in HIV, HBV, HCV, and SARS-CoV-2 infection and explores the prospects of exosome development. These insights may be translated into therapeutic measures for viral infections and reduce the disease burden