40 research outputs found
Investigation and Exploration of ‘Student-Centered and Teacher-Led’ Teaching Model in English Medium Instruction (EMI) Calculus Course
The internationalization of higher education in China is constantly improving with an increasing level of diversification and globalization of education. High-level international English Medium Instruction (EMI) course is crucial to the cultivation of innovative international talents. Taking the Calculus course as an example, this article first demonstrates the importance and connotation of ‘know thy enemy and know yourself’ in the construction of EMI courses. Then it elaborates on the construction methods and significance of the ‘Leaning Community’, ‘Teaching Community’, and ‘Teaching-Learning Community’ through studies of the relationship between ‘teaching’ and ‘learning’ form the student-centered aspect. Such research provides a useful reference for the teaching model reform, especially the effective construction of EMI courses in non-native English-speaking countries
RRescue: Ranking LLM Responses to Enhance Reasoning Over Context
Effectively using a given context is paramount for large language models. A
context window can include task specifications, retrieved documents, previous
conversations, and even model self-reflections, functioning similarly to
episodic memory. While efforts are being made to expand the context window,
studies indicate that LLMs do not use their context optimally for response
generation. In this paper, we present a novel approach to optimize LLMs using
ranking metrics, which teaches LLMs to rank a collection of
contextually-grounded candidate responses. Rather than a traditional full
ordering, we advocate for a partial ordering. This is because achieving
consensus on the perfect order for system responses can be challenging. Our
partial ordering is more robust, less sensitive to noise, and can be acquired
through human labelers, heuristic functions, or model distillation. We test our
system's improved contextual understanding using the latest benchmarks,
including a new multi-document question answering dataset. We conduct ablation
studies to understand crucial factors, such as how to gather candidate
responses, determine their most suitable order, and balance supervised
fine-tuning with ranking metrics. Our approach, named RRescue, suggests a
promising avenue for enhancing LLMs' contextual understanding via response
ranking
Orbital Nature of Carboionic Monoradicals Made from Diradicals
The electronic, optical, and solid state properties of a series of monoradicals, anions and cations obtained from starting neutral diradicals have been studied. Diradicals based on s-indacene and indenoacenes, with benzothiophenes fused and in different orientations, feature a varying degree of diradical character in the neutral state, which is here related with the properties of the radical redox forms. The analysis of their optical features in the polymethine monoradicals has been carried out in the framework of the molecular orbital and valence bond theories. Electronic UVVis-NIR absorption, X-ray solid-state diffraction and quantum
chemical calculations have been carried out. Studies of the different positive-/negative-charged species, both residing in the same skeletal π-conjugated backbone, are rare for organic molecules. The key factor for the dual stabilization is the presence of the starting diradical character that enables to indistinctively accommodate a pseudo-hole and a pseudoelectron defect with certainly small reorganization energies for ambipolar charge transport.The authors thank the Spanish Ministry of Science and Innovation (projects MINECO/FEDER PGC2018-098533-B-100
and PID2021-127127NB-I00) and the Junta de Andalucía, Spain (UMA18FEDERJA057 and Proyecto de Excelencia PROYEXCEL- 00328). We also thank the Research Central Services (SCAI) of the University of Málaga and the US National Science Foundation (CHE-1954389 to M.M.H., CHE-2003411 to M.A. P.). F.N and Y.D. acknowledge support from “Valutazione della Ricerca di Ateneo” (VRA)-University of Bologna. Y.D. acknowledges Ministero dell’Università e della Ricerca (MUR) for her
Ph.D. fellowship.
Funding for open access charge: Universidad de Málaga / CBU
Knowledge mapping and research hotspots of immunotherapy in renal cell carcinoma: A text-mining study from 2002 to 2021
BackgroundRenal cell carcinoma (RCC) is one of the most lethal urological malignancies, and because early-stage RCC is asymptomatic, many patients present metastatic diseases at first diagnosis. With the development of immunotherapy, the treatment of RCC has entered a new stage and has made a series of progress. This study mainly outlines the knowledge map and detects the potential research hotspots by using bibliometric analysis.MethodsPublications concerning RCC immunotherapy from 2002 to 2021 in the Web of Science Core Collection were collected. Visualization and statistical analysis were mainly performed by freeware tools VOSviewer, CiteSpace, R software, and Microsoft Office Excel 2019.ResultsA total of 3,432 papers were collected in this study, and the annual number of papers and citations showed a steady growth trend. The United States is the leading country with the most high-quality publications and is also the country with the most international cooperation. The University of Texas MD Anderson Cancer Center is the most productive organization. The Journal of Clinical Oncology is the highest co-cited journal, and Brian I. Rini is both the most prolific author and the author with the largest centrality. The current research hotspots may be focused on “immune checkpoint inhibitors (ICIs),” “PD-1,” and “mammalian target of rapamycin.”ConclusionImmunotherapy has a bright future in the field of RCC treatment, among which ICIs are one of the most important research hotspots. The main future research directions of ICI-based immunotherapy may focus on combination therapy, ICI monotherapy, and the development of new predictive biomarkers
Near-Space Communications: the Last Piece of 6G Space-Air-Ground-Sea Integrated Network Puzzle
This article presents a comprehensive study on the emerging near-space
communications (NS-COM) within the context of space-air-ground-sea integrated
network (SAGSIN). Specifically, we firstly explore the recent technical
developments of NS-COM, followed by the discussions about motivations behind
integrating NS-COM into SAGSIN. To further demonstrate the necessity of NS-COM,
a comparative analysis between the NS-COM network and other counterparts in
SAGSIN is conducted, covering aspects of deployment, coverage, channel
characteristics and unique problems of NS-COM network. Afterwards, the
technical aspects of NS-COM, including channel modeling, random access, channel
estimation, array-based beam management and joint network optimization, are
examined in detail. Furthermore, we explore the potential applications of
NS-COM, such as structural expansion in SAGSIN communication, civil aviation
communication, remote and urgent communication, weather monitoring and carbon
neutrality. Finally, some promising research avenues are identified, including
stratospheric satellite (StratoSat) -to-ground direct links for mobile
terminals, reconfigurable multiple-input multiple-output (MIMO) and holographic
MIMO, federated learning in NS-COM networks, maritime communication,
electromagnetic spectrum sensing and adversarial game, integrated sensing and
communications, StratoSat-based radar detection and imaging, NS-COM assisted
enhanced global navigation system, NS-COM assisted intelligent unmanned system
and free space optical (FSO) communication. Overall, this paper highlights that
the NS-COM plays an indispensable role in the SAGSIN puzzle, providing
substantial performance and coverage enhancement to the traditional SAGSIN
architecture.Comment: 28 pages, 8 figures, 2 table
VEuPathDB: the eukaryotic pathogen, vector and host bioinformatics resource center in 2023.
The Eukaryotic Pathogen, Vector and Host Informatics Resource (VEuPathDB, https://veupathdb.org) is a Bioinformatics Resource Center funded by the National Institutes of Health with additional funding from the Wellcome Trust. VEuPathDB supports >600 organisms that comprise invertebrate vectors, eukaryotic pathogens (protists and fungi) and relevant free-living or non-pathogenic species or hosts. Since 2004, VEuPathDB has analyzed omics data from the public domain using contemporary bioinformatic workflows, including orthology predictions via OrthoMCL, and integrated the analysis results with analysis tools, visualizations, and advanced search capabilities. The unique data mining platform coupled with >3000 pre-analyzed data sets facilitates the exploration of pertinent omics data in support of hypothesis driven research. Comparisons are easily made across data sets, data types and organisms. A Galaxy workspace offers the opportunity for the analysis of private large-scale datasets and for porting to VEuPathDB for comparisons with integrated data. The MapVEu tool provides a platform for exploration of spatially resolved data such as vector surveillance and insecticide resistance monitoring. To address the growing body of omics data and advances in laboratory techniques, VEuPathDB has added several new data types, searches and features, improved the Galaxy workspace environment, redesigned the MapVEu interface and updated the infrastructure to accommodate these changes
VEuPathDB: the eukaryotic pathogen, vector and host bioinformatics resource center
The Eukaryotic Pathogen, Vector and Host Informatics Resource (VEuPathDB, https://veupathdb.org) represents the 2019 merger of VectorBase with the EuPathDB projects. As a Bioinformatics Resource Center funded by the National Institutes of Health, with additional support from the Welllcome Trust, VEuPathDB supports >500 organisms comprising invertebrate vectors, eukaryotic pathogens (protists and fungi) and relevant free-living or non-pathogenic species or hosts. Designed to empower researchers with access to Omics data and bioinformatic analyses, VEuPathDB projects integrate >1700 pre-analysed datasets (and associated metadata) with advanced search capabilities, visualizations, and analysis tools in a graphic interface. Diverse data types are analysed with standardized workflows including an in-house OrthoMCL algorithm for predicting orthology. Comparisons are easily made across datasets, data types and organisms in this unique data mining platform. A new site-wide search facilitates access for both experienced and novice users. Upgraded infrastructure and workflows support numerous updates to the web interface, tools, searches and strategies, and Galaxy workspace where users can privately analyse their own data. Forthcoming upgrades include cloud-ready application architecture, expanded support for the Galaxy workspace, tools for interrogating host-pathogen interactions, and improved interactions with affiliated databases (ClinEpiDB, MicrobiomeDB) and other scientific resources, and increased interoperability with the Bacterial & Viral BRC
The Prediction of Evacuation Efficiency on Metro Platforms Based on Passengers’ Decision-Making Capability
In the research, decision-making capabilities are explored in relation to the prediction of evacuation efficiency to improve forecast accuracy on metro platforms. For this purpose, this study reviewed theories related to evacuation behaviours utilising the anomaly-seeking approach and the paradigm of relationship development. The conceptual framework of decision-making capability and evacuation behaviours was explored based on risk perception, level of emergency knowledge, survivability and emotion, and their relationship with the partial least squares equation was constructed. A predictive model of evacuation efficiency and its differential equations incorporating this relationship were also proposed based on the epidemic model. By developing and testing the conceptual framework and model, theoretical support is provided for evacuation behaviour, while assisting emergency management in developing plans and measures to respond to emergencies on metro platforms. This study realises the possibility of predicting evacuation efficiency from a decision-making capability perspective