Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Predicting and Analyzing the Popularity of False Rumors in Weibo

Anonymised Raw 19,256 Weibo Rumors. Paper: Predicting and Analyzing the Popularity of False Rumors in Weibo Authors: Yida Mu, Pu Niu, Kalina Bontcheva and Nikolaos Aletras. Pre-print will be available soon. import pandas as pd data=pd.read_csv('Weibo_Rumor_Popularity.tsv', sep='\t', lineterminator='\n') Yida Mu: (i) [email protected] (ii) [email protected]

Shock Vibration Control of SDOF Systems with Tubular Linear Eddy Current Dampers

The nonlinear dynamic characteristic of a tubular linear eddy current damper (TLECD) and the transient responses to shock excitations of a single-degree-of-freedom (SDOF) system with the TLECD are studied. First, the nonlinear force-velocity relationship of the TLECD is discussed using the finite element simulation and mathematical model fitting. Next, the influences of three forms of shock excitation and various mechanical parameters of the TLECD on shock vibration control of an SDOF system with the TLECD are investigated. Moreover, for the SDOF systems with the TLECD or the nonlinear fluid viscous dampers (FVD) at the same maximum displacement and maximum damper force, the time to reach the maximum displacement, the time to reach one-third of the maximum displacement, the energy input of the external loading, and the energy dissipation of dampers are analyzed and compared. Finally, the shock response spectrums (SRSs) of the SDOF system and the design flowchart for the TLECD are presented to provide a reference for shock vibration control of the SDOF system with the nonlinear TLECD and the design of TLECDs. The results show that there is an optimal dimensionless critical relative velocity that minimizes the dimensionless maximum damping force for reaching the target maximum displacement, and compared to the FVD, the TLECD greatly shortens the time to reach one-third of the maximum displacement

Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease

We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases with coronary artery disease and 5,019 controls, followed by de novo replication studies in 15,460 cases and 11,472 controls, all of Chinese Han descent. We successfully identified four new loci for coronary artery disease reaching genome-wide significance (P < 5 × 10(−8)), which mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European populations (PHACTR1, TCF21, CDKN2A/B and C12orf51). These findings provide new insights into biological pathways for the susceptibility of coronary artery disease in Chinese Han population