Nonparametric false discovery rate control for identifying simultaneous signals

It is frequently of interest to jointly analyze multiple sequences of multiple tests in order to identify simultaneous signals, defined as features tested in multiple studies whose test statistics are non-null in each. In many problems, however, the null distributions of the test statistics may be complicated or even unknown, and there do not currently exist any procedures that can be employed in these cases. This paper proposes a new nonparametric procedure that can identify simultaneous signals across multiple studies even without knowing the null distributions of the test statistics. The method is shown to asymptotically control the false discovery rate, and in simulations had excellent power and error control. In an analysis of gene expression and histone acetylation patterns in the brains of mice exposed to a conspecific intruder, it identified genes that were both differentially expressed and next to differentially accessible chromatin. The proposed method is available in the R package github.com/sdzhao/ssa

Li-diffusion accelerates grain growth in intercalation electrodes: a phase-field study

Grain boundary migration is driven by the boundary's curvature and external loads such as temperature and stress. In intercalation electrodes an additional driving force results from Li-diffusion. That is, Li-intercalation induces volume expansion of the host-electrode, which is stored as elastic energy in the system. This stored energy is hypothesized as an additional driving force for grain boundaries and edge dislocations. Here, we apply the 2D Cahn-Hilliard$-$phase-field-crystal (CH-PFC) model to investigate the coupled interactions between highly mobile Li-ions and host-electrode lattice structure, during an electrochemical cycle. We use a polycrystalline FePO$_{4}$/ LiFePO$_{4}$ electrode particle as a model system. We compute grain growth in the FePO$_{4}$ electrode in two parallel studies: In the first study, we electrochemically cycle the electrode and calculate Li-diffusion assisted grain growth. In the second study, we do not cycle the electrode and calculate the curvature-driven grain growth. External loads, such as temperature and stress, did not differ across studies. We find the mean grain-size increases by $\sim11\%$ in the electrochemically cycled electrode particle. By contrast, in the absence of electrochemical cycling, we find the mean grain-size increases by $\sim2\%$ in the electrode particle. These CH-PFC computations suggest that Li-intercalation accelerates grain-boundary migration in the host-electrode particle. The CH-PFC simulations provide atomistic insights on diffusion-induced grain-boundary migration, edge dislocation movement and triple-junction drag-effect in the host-electrode microstructure.Comment: 11 pages, 9 figure

Understanding gratitude: Starting from its conceptualisations.

The study of gratitude has been started since decades ago. This single word “gratitude” has been defined in many different ways. Apparently, this is rather confusing for new researchers to understand gratitude from diverse perspectives

Kajian Indeks Keupayaan Proses Bagi Taburan Taknormal

Pada zaman yang mencabar ini, penekanan terhadap kualiti merupakan pengurusan yang penting untuk memenuhi kehendak pelanggan dan seterusnya mengekalkan cabaran dan menguasai pasaran. Demi membaiki kualiti, produk dihasilkan bukan sahaja perlu mematuhi spesifikasi-spesifikasi bahkan pengurangan variasi di antara unit ke unit dan variasi daripada sasaran. In today's challenging world, quality management is a very important factor in satisfying customers' requirements, maintain the competitive edge and market share. In order to improve the quality of products, the variation between unit to unit and the variation from the target need to be reduced besides requiring the units to meet the specifications

Producing High Concentrations of Hydrogen in Palladium via Electrochemical Insertion from Aqueous and Solid Electrolytes

Metal hydrides are critical materials in numerous technologies including hydrogen storage, gas separation, and electrocatalysis. Here, using Pd-H as a model metal hydride, we perform electrochemical insertion studies of hydrogen via liquid and solid state electrolytes at 1 atm ambient pressure, and achieve H:Pd ratios near unity, the theoretical solubility limit. We show that the compositions achieved result from a dynamic balance between the rate of hydrogen insertion and evolution from the Pd lattice, the combined kinetics of which are sufficiently rapid that operando experiments are necessary to characterize instantaneous PdHx composition. We use simultaneous electrochemical insertion and X-ray diffraction measurements, combined with a new calibration of lattice parameter versus hydrogen concentration, to enable accurate quantification of the composition of electrochemically synthesized PdHx. Furthermore, we show that the achievable hydrogen concentration is severely limited by electrochemomechanical damage to the palladium and/or substrate. The understanding embodied in these results helps to establish new design rules for achieving high hydrogen concentrations in metal hydrides.Comment: 38 page

A Conceptual Paper on Cross-Border Vertical Integration of Thailand Firms in Southeast Asia Countries: Financial Perspectives.

A considerable number of established and successful Thailand firms have increased their investments in domestic and regional markets. Their international expansions could be due to positive drivers such as financial strength. But the financial factors which contribute to their markets expansions have not been thoroughly explored. Thus, this study examines the effects of financial perspectives on cross-border vertical integration of Thailand firms in Southeast Asia countries, and applies the theory of coinsurance effects. Internationalization helps to reduce cost of capital and increases the availability of getting additional financing. The variables used in measuring finance perspectives include profitability, liquidity, firms’ leverage and foreign exchange rate. Moreover, the study seeks to investigate the impact of vertical integration on the performance of Thailand firms in ASEAN countries. In achieving these objectives, the study also accounts for firm size, firm age, cultural distance, geographic distance and Gross Domestic Products. The study plans to employ regression analysis on panel data for 2012-2016 period using secondary data from 48 Thailand firms with vertical integration and 50 firms with nonvertical integration. The study also assesses the effectiveness of vertical integration in South East Asian countries by comparing their impacts on short-term and long-term. This study has fundamental implications because it emphasizes the financial factors which affect higher valueadded and effective firms’ performance as firms expand through cross-border business. The finding would be useful to stakeholders in decision-making within the context of cross-border vertical integration. From the findings, the study makes some recommendations

Oligoclonal reconstitution masquerading as myeloma relapse

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