275 research outputs found
Modeling the Field Emission Current Fluctuation in Carbon Nanotube Thin Films
Owing to their distinct properties, carbon nanotubes (CNTs) have emerged as
promising candidate for field emission devices. It has been found
experimentally that the results related to the field emission performance show
variability. The design of an efficient field emitting device requires the
analysis of the variabilities with a systematic and multiphysics based modeling
approach. In this paper, we develop a model of randomly oriented CNTs in a thin
film by coupling the field emission phenomena, the electron-phonon transport
and the mechanics of single isolated CNT. A computational scheme is developed
by which the states of CNTs are updated in time incremental manner. The device
current is calculated by using Fowler-Nordheim equation for field emission to
study the performance at the device scale.Comment: 4 pages, 5 figure
Modelling of atmospheric boundary layer: Generation of shear.
Roughness length, z0 and friction velocity, u* are the defining parameters of wind log profile that must be matched in wind tunnel simulation. To fully understand the role of these parameters, the basics and review from the primitive equations and its relation to the logarithmic profile obtained for wind tunnel conditions were discussed. The problem of roughness, although well known, still needs to be addressed more rigorously especially when determining values of z0 and u* from wind tunnel data and their relation to the roughness element geometry. A review of classic literature and new published material were carried out, focusing on the applicability to wind tunnel modelling
Spectrum of Sizes for Perfect Deletion-Correcting Codes
One peculiarity with deletion-correcting codes is that perfect
-deletion-correcting codes of the same length over the same alphabet can
have different numbers of codewords, because the balls of radius with
respect to the Levenshte\u{\i}n distance may be of different sizes. There is
interest, therefore, in determining all possible sizes of a perfect
-deletion-correcting code, given the length and the alphabet size~.
In this paper, we determine completely the spectrum of possible sizes for
perfect -ary 1-deletion-correcting codes of length three for all , and
perfect -ary 2-deletion-correcting codes of length four for almost all ,
leaving only a small finite number of cases in doubt.Comment: 23 page
Controlled assembly of SNAP-PNA-fluorophore systems on DNA templates to produce fluorescence resonance energy transfer
The SNAP protein is a widely used self-labeling tag that can be used for tracking protein localization and trafficking in living systems. A model system providing controlled alignment of SNAP-tag units can provide a new way to study clustering of fusion proteins. In this work, fluorescent SNAP-PNA conjugates were controllably assembled on DNA frameworks forming dimers, trimers, and tetramers. Modification of peptide nucleic acid (PNA) with the O6-benzyl guanine (BG) group allowed the generation of site-selective covalent links between PNA and the SNAP protein. The modified BG-PNAs were labeled with fluorescent Atto dyes and subsequently chemo-selectively conjugated to SNAP protein. Efficient assembly into dimer and oligomer forms was verified via size exclusion chromatography (SEC), electrophoresis (SDS-PAGE), and fluorescence spectroscopy. DNA directed assembly of homo- and hetero-dimers of SNAP-PNA constructs induced homo- and hetero-FRET, respectively. Longer DNA scaffolds controllably aligned similar fluorescent SNAP-PNA constructs into higher oligomers exhibiting homo-FRET. The combined SEC and homo-FRET studies indicated the 1:1 and saturated assemblies of SNAP-PNA-fluorophore:DNA formed preferentially in this system. This suggested a kinetic/stoichiometric model of assembly rather than binomially distributed products. These BG-PNA-fluorophore building blocks allow facile introduction of fluorophores and/or assembly directing moieties onto any protein containing SNAP. Template directed assembly of PNA modified SNAP proteins may be used to investigate clustering behavior both with and without fluorescent labels which may find use in the study of assembly processes in cells
Re-examining the Unified Theory of Acceptance and Use of Technology (UTAUT): Towards a Revised Theoretical Model
YesBased on a critical review of the Unified Theory of Acceptance and Use of Technology (UTAUT), this study first formalized an alternative theoretical model for explaining the acceptance and use of information system (IS) and information technology (IT) innovations. The revised theoretical model was then empirically examined using a combination of meta-analysis and structural equation modelling (MASEM) techniques. The meta-analysis was based on 1600 observations on 21 relationships coded from 162 prior studies on IS/IT acceptance and use. The SEM analysis showed that attitude: was central to behavioural intentions and usage behaviours, partially mediated the effects of exogenous constructs on behavioural intentions, and had a direct influence on usage behaviours. A number of implications for theory and practice are derived based on the findings
Universal emission intermittency in quantum dots, nanorods, and nanowires
Virtually all known fluorophores, including semiconductor nanoparticles,
nanorods and nanowires exhibit unexplainable episodes of intermittent emission
blinking. A most remarkable feature of the fluorescence intermittency is a
universal power law distribution of on- and off-times. For nanoparticles the
resulting power law extends over an extraordinarily wide dynamic range: nine
orders of magnitude in probability density and five to six orders of magnitude
in time. The exponents hover about the ubiquitous value of -3/2. Dark states
routinely last for tens of seconds, which are practically forever on quantum
mechanical time scales. Despite such infinite states of darkness, the dots
miraculously recover and start emitting again. Although the underlying
mechanism responsible for this phenomenon remains an enduring mystery and many
questions remain, we argue that substantial theoretical progress has been made.Comment: 9 pages, 2 figures, Accepted versio
Direct application of plasmid DNA containing type I interferon transgenes to vaginal mucosa inhibits HSV-2 mediated mortality
The application of naked DNA containing type I interferon (IFN) transgenes is a promising potential therapeutic approach for controlling chronic viral infections. Herein, we detail the application of this approach that has been extensively used to restrain ocular HSV-1 infection, for antagonizing vaginal HSV-2 infection. We show that application of IFN-α1, -α5, and –β transgenes to vaginal mouse lumen 24 hours prior to HSV-2 infection reduces HSV-2 mediated mortality by 2.5 to 3-fold. However, other type I IFN transgenes (IFN- α4, -α5, -α6, and –α9) are non effectual against HSV-2. We further show that the efficacy of IFN-α1 transgene treatment is independent of CD4+ T lymphocytes. However, in mice depleted of CD8+ T lymphocytes, the ability of IFN-α1 transgene treatment to antagonize HSV-2 was lost
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