6 research outputs found
Uranus evolution models with simple thermal boundary layers
The strikingly low luminosity of Uranus (Teff ~ Teq) constitutes a
long-standing challenge to our understanding of Ice Giant planets. Here we
present the first Uranus structure and evolution models that are constructed to
agree with both the observed low luminosity and the gravity field data. Our
models make use of modern ab initio equations of state at high pressures for
the icy components water, methane, and ammonia. Proceeding step by step, we
confirm that adiabatic models yield cooling times that are too long, even when
uncertainties in the ice:rock ratio (I:R) are taken into account. We then argue
that the transition between the ice/rock-rich interior and the H/He-rich outer
envelope should be stably stratified. Therefore, we introduce a simple thermal
boundary and adjust it to reproduce the low luminosity. Due to this thermal
boundary, the deep interior of the Uranus models are up to 2--3 warmer than
adiabatic models, necessitating the presence of rocks in the deep interior with
a possible I:R of solar. Finally, we allow for an equilibrium
evolution (Teff ~ Teq) that begun prior to the present day, which would
therefore no longer require the current era to be a "special time" in Uranus'
evolution. In this scenario, the thermal boundary leads to more rapid cooling
of the outer envelope. When Teff ~ Teq is reached, a shallow, subadiabatic zone
in the atmosphere begins to develop. Its depth is adjusted to meet the
luminosity constraint. This work provides a simple foundation for future Ice
Giant structure and evolution models, that can be improved by properly treating
the heat and particle fluxes in the diffusive zones.Comment: 13 pages, Accepted to Icaru
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Uranus evolution models with simple thermal boundary layers
The strikingly low luminosity of Uranus (Teff ~ Teq) constitutes a
long-standing challenge to our understanding of Ice Giant planets. Here we
present the first Uranus structure and evolution models that are constructed to
agree with both the observed low luminosity and the gravity field data. Our
models make use of modern ab initio equations of state at high pressures for
the icy components water, methane, and ammonia. Proceeding step by step, we
confirm that adiabatic models yield cooling times that are too long, even when
uncertainties in the ice:rock ratio (I:R) are taken into account. We then argue
that the transition between the ice/rock-rich interior and the H/He-rich outer
envelope should be stably stratified. Therefore, we introduce a simple thermal
boundary and adjust it to reproduce the low luminosity. Due to this thermal
boundary, the deep interior of the Uranus models are up to 2--3 warmer than
adiabatic models, necessitating the presence of rocks in the deep interior with
a possible I:R of solar. Finally, we allow for an equilibrium
evolution (Teff ~ Teq) that begun prior to the present day, which would
therefore no longer require the current era to be a "special time" in Uranus'
evolution. In this scenario, the thermal boundary leads to more rapid cooling
of the outer envelope. When Teff ~ Teq is reached, a shallow, subadiabatic zone
in the atmosphere begins to develop. Its depth is adjusted to meet the
luminosity constraint. This work provides a simple foundation for future Ice
Giant structure and evolution models, that can be improved by properly treating
the heat and particle fluxes in the diffusive zones
Secreted Osteopontin Is Highly Polymerized in Human Airways and Fragmented in Asthmatic Airway Secretions
BACKGROUND: Osteopontin (OPN) is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family and a cytokine with diverse biologic roles. OPN undergoes extensive post-translational modifications, including polymerization and proteolytic fragmentation, which alters its biologic activity. Recent studies suggest that OPN may contribute to the pathogenesis of asthma. METHODOLOGY: To determine whether secreted OPN (sOPN) is polymerized in human airways and whether it is qualitatively different in asthma, we used immunoblotting to examine sOPN in bronchoalveolar lavage (BAL) fluid samples from 12 healthy and 21 asthmatic subjects (and in sputum samples from 27 healthy and 21 asthmatic subjects). All asthmatic subjects had mild to moderate asthma and abstained from corticosteroids during the study. Furthermore, we examined the relationship between airway sOPN and cellular inflammation. PRINCIPAL FINDINGS: We found that sOPN in BAL fluid and sputum exists in polymeric, monomeric, and cleaved forms, with most of it in polymeric form. Compared to healthy subjects, asthmatic subjects had proportionately less polymeric sOPN and more monomeric and cleaved sOPN. Polymeric sOPN in BAL fluid was associated with increased alveolar macrophage counts in airways in all subjects. CONCLUSIONS: These results suggest that sOPN in human airways (1) undergoes extensive post-translational modification by polymerization and proteolytic fragmentation, (2) is more fragmented and less polymerized in subjects with mild to moderate asthma, and (3) may contribute to recruitment or survival of alveolar macrophages