15,177 research outputs found
MHD boundary layers with non-equilibrium ionization and finite rates Quarterly report, 1 Jun. - 1 Sep. 1969
Ionization and recombination rates in boundary layer of magnetohydrodynamic channel electrod
Average and worst-case specifications of precipitating auroral electron environment
The precipitation electrons in the auroral environment are highly variable in their energy and intensity in both space and time. As such they are a source of potential hazard to the operation of the Space Shuttle and other large spacecraft operating in polar orbit. In order to assess these hazards both the average and extreme states of the precipitating electrons must be determined. Work aimed at such a specification is presented. First results of a global study of the average characteristics are presented. In this study the high latitude region was divided into spatial elements in magnetic local time and corrected geomagnetic latitude. The average electron spectrum was then determined in each spatial element for seven different levels of activity as measured by K sub p using an extremely large data set of auroral observations. Second a case study of an extreme auroral electron environment is presented, in which the electrons are accelerated through field aligned potential as high as 30,000 volts and in which the spacecraft is seen to charge negatively to a potential approaching .5 kilovolts
High Reynolds number and turbulence effects on aerodynamics and heat transfer in a turbine cascade
Experimental data on pressure distribution and heat transfer on a turbine airfoil were obtained over a range of Reynolds numbers from 0.75 to 7.5 x 10 exp 6 and a range of turbulence intensities from 1.8 to about 15 percent. The purpose of this study was to obtain fundamental heat transfer and pressure distribution data over a wide range of high Reynolds numbers and to extend the heat transfer data base to include the range of Reynolds numbers encountered in the Space Shuttle main engine (SSME) turbopump turbines. Specifically, the study aimed to determine (1) the effect of Reynolds number on heat transfer, (2) the effect of upstream turbulence on heat transfer and pressure distribution, and (3) the relationship between heat transfer at high Reynolds numbers and the current data base. The results of this study indicated that Reynolds number and turbulence intensity have a large effect on both the transition from laminar to turbulent flow and the resulting heat transfer. For a given turbulence intensity, heat transfer for all Reynolds numbers at the leading edge can be correlated with the Frossling number developed for lower Reynolds numbers. For a given turbulence intensity, heat transfer for the airfoil surfaces downstream of the leading edge can be approximately correlated with a dimensionless parameter. Comparison of the experimental results were also made with a numerical solution from a two-dimensional Navier-Stokes code
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JAK2-STAT5 signaling: A novel mechanism of resistance to targeted PI3K/mTOR inhibition
A recent article published by Britschgi et al. in Cancer Cell, “JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade: A Rationale for Cotargeting These Pathways in Metastatic Breast Cancer,” describes a positive feedback loop of JAK2/STAT5 activation that drives resistance to PI3K/mTOR inhibition in breast cancer. The authors found that genetic or pharmacological inhibition of JAK2 circumvents resistance to PI3K/mTOR inhibition and go on to show the efficacy of combined PI3K/mTOR and JAK2 inhibition on reducing cancer cell number, tumor growth, and metastasis as well as increasing in vivo survival. These results provide strong support for combination therapy with JAK2/STAT5 and PI3K/mTOR inhibitors in breast cancer. Here we discuss how the article by Britschgi et al. proposes a novel mechanism to explain how breast cancer cells overcome inhibition of a key signaling pathway driving cell proliferation. We also discuss the interplay between activation of the transcription factors STAT5 and STAT3 in breast cancer
Gigantic transmission band edge resonance in periodic stacks of anisotropic layers
We consider Fabry-Perot cavity resonance in periodic stacks of anisotropic
layers with misaligned in-plane anisotropy at the frequency close to a photonic
band edge. We show that in-plane dielectric anisotropy can result in a dramatic
increase in field intensity and group delay associated with the transmission
resonance. The field enhancement appears to be proportional to forth degree of
the number N of layers in the stack. By contrast, in common periodic stacks of
isotropic layers, those effects are much weaker and proportional to N^2. Thus,
the anisotropy allows to drastically reduce the size of the resonance cavity
with similar performance. The key characteristic of the periodic arrays with
the gigantic transmission resonance is that the dispersion curve omega(k)at the
photonic band edge has the degenerate form Delta(omega) ~ Delta(k)^4, rather
than the regular form Delta(omega) ~ Delta(k)^2. This can be realized in
specially arranged stacks of misaligned anisotropic layers. The degenerate band
edge cavity resonance with similar outstanding properties can also be realized
in a waveguide environment, as well as in a linear array of coupled multimode
resonators, provided that certain symmetry conditions are in place.Comment: To be submitted to Phys. Re
M\"{o}ssbauer study of the '11' iron-based superconductors parent compound Fe(1+x)Te
57Fe Moessbauer spectroscopy was applied to investigate the superconductor
parent compound Fe(1+x)Te for x=0.06, 0.10, 0.14, 0.18 within the temperature
range 4.2 K - 300 K. A spin density wave (SDW) within the iron atoms occupying
regular tetrahedral sites was observed with the square root of the mean square
amplitude at 4.2 K varying between 9.7 T and 15.7 T with increasing x. Three
additional magnetic spectral components appeared due to the interstitial iron
distributed over available sites between the Fe-Te layers. The excess iron
showed hyperfine fields at approximately 16 T, 21 T and 49 T for three
respective components at 4.2 K. The component with a large field of 49 T
indicated the presence of isolated iron atoms with large localized magnetic
moment in interstitial positions. Magnetic ordering of the interstitial iron
disappeared in accordance with the fallout of the SDW with the increasing
temperature
Effect of Strain Relaxation on Magnetotransport properties of epitaxial La_0.7Ca_0.3MnO_3 films
In this paper, we have studied the effect of strain relaxation on
magneto-transport properties of La_0.7Ca_0.3MnO_3 epitaxial films (200 nm
thick), which were deposited by pulsed laser deposition technique under
identical conditions. All the films are epitaxial and have cubic unit cell. The
amount of strain relaxation has been varied by taking three different single
crystal substrates of SrTiO_3, LaAlO_3 and MgO. It has been found that for
thicker films the strain gets relaxed and produces variable amount of disorder
depending on the strength of strain relaxation. The magnitude of lattice
relaxation has been found to be 0.384, 3.057 and 6.411 percent for film
deposited on SrTiO_3, LaAlO_3 and MgO respectively. The films on LaAlO_3 and
SrTiO_3 show higher T_{IM} of 243 K and 217 K respectively as compared to
T_{IM} of 191 K for the film on MgO. Similarly T_C of the films on SrTiO_3 and
LaAlO_3 is sharper and has value of 245 K and 220 K respectively whereas the TC
of the film on MgO is 175 K. Higher degree of relaxation creates more defects
and hence TIM (T_C) of the film on MgO is significantly lower than of SrTiO_3
and LaAlO_3. We have adopted a different approach to correlate the effect of
strain relaxation on magneto-transport properties of LCMO films by evaluating
the resistivity variation through Mott's VRH model. The variable presence of
disorder in these thick films due to lattice relaxation which have been
analyzed through Mott's VRH model provides a strong additional evidence that
the strength of lattice relaxation produces disorder dominantly by increase in
density of defects such as stacking faults, dislocations, etc. which affect the
magneto-transport properties of thick epitaxial La_0.7Ca_0.3MnO_3 films
Service delivery interventions to increase uptake of voluntary medical male circumcision for HIV prevention: A systematic review.
BackgroundVoluntary medical male circumcision (VMMC) remains an essential component of combination HIV prevention services, particularly in priority countries in sub-Saharan Africa. As VMMC programs seek to maximize impact and efficiency, and to support World Health Organization guidance, specific uptake-enhancing strategies are critical to identify.MethodsWe systematically reviewed the literature to evaluate the impact of service delivery interventions (e.g., facility layout, service co-location, mobile outreach) on VMMC uptake among adolescent and adult men. For the main effectiveness review, we searched for publications or conference abstracts that measured VMMC uptake or uptake of HIV testing or risk reduction counselling within VMMC services. We synthesized data by coding categories and outcomes. We also reviewed studies assessing acceptability, values/preferences, costs, and feasibility.ResultsFour randomized controlled trials and five observational studies were included in the effectiveness review. Studies took place in South Africa, Tanzania, Uganda, Zambia, and Zimbabwe. They assessed a range of service delivery innovations, including community-, school-, and facility-based interventions. Overall, interventions increased VMMC uptake; some successfully improved uptake among age-specific subpopulations, but urban-rural stratification showed no clear trends. Interventions that increased adult men's uptake included mobile services (compared to static facilities), home-based testing with active referral follow-up, and facility-based HIV testing with enhanced comprehensive sexual education. Six acceptability studies suggested interventions were generally perceived to help men choose to get circumcised. Eleven cost studies suggested interventions create economies-of-scale and efficiencies. Three studies suggested such interventions were feasible, improving facility preparedness, service quality and quantity, and efficiencies.ConclusionsInnovative changes in male-centered VMMC services can improve adult men's and adolescent boys' VMMC uptake. Limited evidence on interventions that enhance access and acceptability show promising results, but evidence gaps persist due to inconsistent intervention definition and delivery, due in part to contextual relevance and limited age disaggregation
Economic compensation interventions to increase uptake of voluntary medical male circumcision for HIV prevention: A systematic review and meta-analysis.
BackgroundEconomic compensation interventions may help support higher voluntary medical male circumcision (VMMC) coverage in priority sub-Saharan African countries. To inform World Health Organization guidelines, we conducted a systematic review of economic compensation interventions to increase VMMC uptake.MethodsEconomic compensation interventions were defined as providing money or in-kind compensation, reimbursement for associated costs (e.g. travel, lost wages), or lottery entry. We searched five electronic databases and four scientific conferences for studies examining the impact of such interventions on VMMC uptake, HIV testing and safer-sex/risk-reduction counseling uptake within VMMC, community expectations about compensation, and potential coercion. We screened citations, extracted data, and assessed risk of bias in duplicate. We conducted random-effects meta-analysis. We also reviewed studies examining acceptability, values/preferences, costs, and feasibility.ResultsOf 2484 citations identified, five randomized controlled trials (RCTs) and three non-randomized controlled trials met our eligibility criteria. Studies took place in Kenya, Malawi, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe. Meta-analysis of four RCTs showed significant impact of any economic compensation on VMMC uptake (relative risk: 5.23, 95% CI: 3.13 to 8.76). RCTs of food/transport vouchers and conditional cash transfers generally showed increases in VMMC uptake, but lotteries, subsidized VMMC, and receiving a gift appeared somewhat less effective. Three non-randomized trials showed mixed impact. Six additional studies suggested economic compensation interventions were generally acceptable, valued for addressing key barriers, and motivating to men. However, some participants felt they were insufficiently motivating or necessary; one study suggested they might raise community suspicions. One study from South Africa found a program cost of US450-$1350 per HIV infection averted.ConclusionsEconomic compensation interventions, particularly transport/food vouchers, positively impacted VMMC uptake among adult men and were generally acceptable to potential clients. Carefully selected economic interventions may be a useful targeted strategy to enhance VMMC coverage
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