Laryngocele in association with ankylosing spondylitis

WOS: 000233627600010PubMed: 16416373A laryngocele is a cystic dilatation of the laryngeal saccule. The etiology of laryngoceles is unclear, but congenital and acquired factors are considered to play a role in their development. An acquired laryngocele may develop when the laryngeal ventricle becomes functionally obstructed as a result of an increase in intraglottic pressure, such as that caused by excessive coughing, playing a wind instrument, glass blowing or obstruction of appendicular ostium. We present a case of laryngocele in a patient with ankylosing spondylitis. To the authors' knowledge, and from a review of the literature, this combination has not been previously described. The laryngocele was also infected in this case. We believe that development of the laryngocele might be a result of increased intra-abdominal pressure, caused by rheumatoid arthritis, with associated increased intralaryngeal pressure

Genç-erişkin şizofreni hastalarında kemik mineral yoğunluğu düzeyinin sağlıklı kontrollerle karşılaştırılması

Amaç: Bu çalışmanın amacı, genç-erişkin şizofreni hastalarında kemik mineral yoğunluğunun değerlendirilmesi ve sağlıklı kontrollerle karşılaştırılmasıdır. Yöntem: Bu kesitsel çalışmaya, yaşları 22 ve 44 arasında değişen 14 şizofreni hastası ve kontrol grubu olarak, 31 sağlıklı birey dahil edildi. Her iki grubun kemik mineral yoğunluğu ölçümü Dual Energy X-ray Absorbiometry (DEXA) ile yapıldı. Hastalar, Pozitif ve Negatif Semptom Ölçeği (PANSS) ile değerlendirildi. Hastaların tamamı, en az 2 yıldır şizofreni tanısı ile antipsikotik kullanmaktaydı. Hastaların sosyodemografik özellikleri ve osteopo roz için risk faktörleri (antipsikotik kullanımı, güneş ışınlarına maruziyet, fiziksel aktivite, vs.) sorgulanarak kemik mineral yoğunluğu ile ilişkisi araştırıldı. Bulgular: Sağlıklı kontrollerle karşılaştırıldığında, şizofreni hastalarında, hem lomber omurgada hem de proksi mal femurun tüm bölgelerinde kemik mineral yoğunluğu daha düşüktü. Bağıntı analizi sonucunda, şizofreni hastalarında, yalnızca femur bölgesindeki kemik mineral yoğunluğu ile ilişkili tek faktör olarak yaş bulundu. Kemik mineral yoğunluğu ile cinsiyetin, PANSS skorlarının, kullanılan antipsikotik türünün ve osteoporoz için risk faktörü olan diğer etkenlerin ilişkisi olmadığı tespit edildi. Sonuç: Bu çalışmada şizofreni hastalarının kemik mineral yoğunluğunun, sağlıklı bireylere göre daha düşük bulunması, şizofreni olgularında genç yaşta osteoporotik değişikliklerin olabileceğini düşündürmektedir. Şizofreni ve osteoporoz arasındaki ilişkiyi daha iyi açığa çıkaracak prospektif çalışmalara ihtiyaç vardır.Objective: The aim of this study was to assess bone mineral density levels of patients with schizophrenia and to compare the results with healthy controls. Methods: Fourteen patients with schizophrenia and 31 healthy controls, between 22 and 44 years of age, were enrolled in this cross-sectional study. Bone mineral density (BMD) levels of each group were measured by Dual Energy X-ray Absorbiometry (DEXA). The patients were assessed using the Positive and Negative Symptom Scale (PANSS). All patients had been receiving antipsychotic treatment for at least 2 years. Patients’ sociodemographic caharacteristics and risk factors for osteoporosis (antipsychotic use, sunlight exposure, physical activity, etc.) were documented. Results: As compared with the healthy controls, the patients with schizophrenia had significantly lower BMD at the lumbar spine and at all sites of the proximal femur. Correlation analysis showed that the only factor related with the femoral BMD only in patients with schizophrenia was the age. No association between BMD and gender, PANSS score, type of antipsychotic medications, and other risk factors for osteoporosis were observed. Conclusions: In this study, we found that BMD in schizophrenia patients was lower than that of healthy controls and this finding suggest that osteoporotic changes may be seen in younger ages. Further prospective studies are needed to better clarify the relationship between osteoporosis and schizophrenia

Genç-erişkin şizofreni hastalarında kemik mineral yoğunluğu düzeyinin sağlıklı kontrollerle karşılaştırılması

Amaç: Bu çalışmanın amacı, genç-erişkin şizofreni hastalarında kemik mineral yoğunluğunun değerlendirilmesi ve sağlıklı kontrollerle karşılaştırılmasıdır. Yöntem: Bu kesitsel çalışmaya, yaşları 22 ve 44 arasında değişen 14 şizofreni hastası ve kontrol grubu olarak, 31 sağlıklı birey dahil edildi. Her iki grubun kemik mineral yoğunluğu ölçümü Dual Energy X-ray Absorbiometry (DEXA) ile yapıldı. Hastalar, Pozitif ve Negatif Semptom Ölçeği (PANSS) ile değerlendirildi. Hastaların tamamı, en az 2 yıldır şizofreni tanısı ile antipsikotik kullanmaktaydı. Hastaların sosyodemografik özellikleri ve osteopo roz için risk faktörleri (antipsikotik kullanımı, güneş ışınlarına maruziyet, fiziksel aktivite, vs.) sorgulanarak kemik mineral yoğunluğu ile ilişkisi araştırıldı. Bulgular: Sağlıklı kontrollerle karşılaştırıldığında, şizofreni hastalarında, hem lomber omurgada hem de proksi mal femurun tüm bölgelerinde kemik mineral yoğunluğu daha düşüktü. Bağıntı analizi sonucunda, şizofreni hastalarında, yalnızca femur bölgesindeki kemik mineral yoğunluğu ile ilişkili tek faktör olarak yaş bulundu. Kemik mineral yoğunluğu ile cinsiyetin, PANSS skorlarının, kullanılan antipsikotik türünün ve osteoporoz için risk faktörü olan diğer etkenlerin ilişkisi olmadığı tespit edildi. Sonuç: Bu çalışmada şizofreni hastalarının kemik mineral yoğunluğunun, sağlıklı bireylere göre daha düşük bulunması, şizofreni olgularında genç yaşta osteoporotik değişikliklerin olabileceğini düşündürmektedir. Şizofreni ve osteoporoz arasındaki ilişkiyi daha iyi açığa çıkaracak prospektif çalışmalara ihtiyaç vardır.Objective: The aim of this study was to assess bone mineral density levels of patients with schizophrenia and to compare the results with healthy controls. Methods: Fourteen patients with schizophrenia and 31 healthy controls, between 22 and 44 years of age, were enrolled in this cross-sectional study. Bone mineral density (BMD) levels of each group were measured by Dual Energy X-ray Absorbiometry (DEXA). The patients were assessed using the Positive and Negative Symptom Scale (PANSS). All patients had been receiving antipsychotic treatment for at least 2 years. Patients’ sociodemographic caharacteristics and risk factors for osteoporosis (antipsychotic use, sunlight exposure, physical activity, etc.) were documented. Results: As compared with the healthy controls, the patients with schizophrenia had significantly lower BMD at the lumbar spine and at all sites of the proximal femur. Correlation analysis showed that the only factor related with the femoral BMD only in patients with schizophrenia was the age. No association between BMD and gender, PANSS score, type of antipsychotic medications, and other risk factors for osteoporosis were observed. Conclusions: In this study, we found that BMD in schizophrenia patients was lower than that of healthy controls and this finding suggest that osteoporotic changes may be seen in younger ages. Further prospective studies are needed to better clarify the relationship between osteoporosis and schizophrenia

Comparison of bone mineral density levels in young-adult patients with schizophrenia and healthy controls

Objective: The aim of this study was to assess bone mineral density levels of patients with schizophrenia and to compare the results with healthy controls. Methods: Fourteen patients with schizophrenia and 31 healthy controls, between 22 and 44 years of age, were enrolled in this cross-sectional study. Bone mineral density (BMD) levels of each group were measured by Dual Energy X-ray Absorbiometry (DEXA). The patients were assessed using the Positive and Negative Symptom Scale (PANSS). All patients had been receiving antipsychotic treatment for at least 2 years. Patients' sociodemographic caharacteristics and risk factors for osteoporosis (antipsychotic use, sunlight exposure, physical activity, etc.) were documented. Results: As compared with the healthy controls, the patients with schizophrenia had significantly lower BMD at the lumbar spine and at all sites of the proximal femur. Correlation analysis showed that the only factor related with the femoral BMD only in patients with schizophrenia was the age. No association between BMD and gender, PANSS score, type of antipsychotic medications, and other risk factors for osteoporosis were observed. Conclusions: In this study, we found that BMD in schizophrenia patients was lower than that of healthy controls and this finding suggest that osteoporotic changes may be seen in younger ages. Further prospective studies are needed to better clarify the relationship between osteoporosis and schizophrenia

Relationship between angiographically documented coronary artery disease and low bone mass in men

WOS: 000247674800016PubMed: 17587717Background The present study aimed to investigate the association between low bone mass (LBM) and coronary artery disease (CAD) in male patients. Method and Results The data for 47 men who were screened for osteopenia and osteoporosis with dual energy X-ray absorptiometry and then underwent coronary angiography between February 2005 and May 2006 were retrospectively analyzed. Bone mineral density of the femur neck was stratified as normal (T score >-1.0 SD) or low (T score = 50% occlusion in at least 1 major coronary artery. Thirty-two patients were found to have angiographically significant CAD. Patients in the LBM group had a significantly higher incidence of CAD. Low bone mass was significantly and positively correlated with the Gensini scores of the patients (r=0.6037, p 75% confirmed the same results. Conclusion Low bone mass was significantly associated with angiographically documented CAD in males

Rheumatoid Arthritis Associated with Bilateral Sacroileitis

WOS: 000269581400010Rheumatoid arthritis is an autoimmune disease which is progressive, systemic, chronic, characterized by erosive sinovitis, having unknown etiology and involving joints symmetrically. Rheumatoid arthritis often affects peripheral joints but its axial skeleton involvement is rare. While cervical joints are involved in the vertebral column, sacroiliac joint involvement can be seen rarely. In this case report, a rheumatoid arthritis case with bilateral sacroiliac joint involvement is discussed with differential diagnosis together with the relevant literature. Turk J Phys Med Rehab 2009;55:42-4

The Relationship Between Lipid Levels And Bone Mineral Density in Postmenopausal Women

Amaç: Bu çalışmanın amacı postmenapozal kadınlarda lipid düzeyleri ile kemik mineral yoğunluğu arasındaki ilişkiyi araştırmaktır. Yöntem: Çalışmaya Düzce Üniversitesi Tıp Fakültesi Fiziksel Tıp ve Rehabilitasyon AD. polikliniğine başvuran 45-65 yaşları arası (ortalama yaş 54) 276 postmenopozal kadın alındı. Lomber vertebra ve femur boynu kemik mineral yoğunlukları dual enerji X ray absorbsiyometre ile, 12 saat süren açlık sonrası alınan kan örneklerinden serum total kolesterol, lipoproteinler ve trigliserid ölçüldü Çalışmaya hormon replasman ve lipid düzeyi düşürücü tedavi alanlar dahil edilmedi. Çalışmaya alınan tüm kadınlara osteoporoz sorgulama formu dolduruldu. Bulgular: Serum lipoproteinleri, total kolesterol ve trigliserid ile femur boynu ve lomber vertebra kemik mineral yoğunlukları arasında anlamlılık bulunamadı (p0,05). Yüksek vücut kitle indeksi ile femur boynu ve lomber vertebrada yüksek kemik mineral yoğunluğu istatistiksel olarak anlamlı bulundu (p0,001). Sonuç: Postmenopozal kadınlarda kemik mineral yoğunluğu ile lipid düzeyleri arasında istatistiksel olarak anlamlı bir ilişki bulunamadı.Objective: The aim of this study is to investigate the relationship between lipid levels and bone mineral density in postmenopausal women Methods: We studied 276 postmenopausal women aged 45- 65 years (mean 54 years) who attended Duzce University faculty of medicine physical medicine and rehabilitation polyclinic. Bone mineral density in the lumbar spine and femur neck were measured by dual energy X-ray absorptiometry. Serum cholesterol, lipoproteins and triglyceride were assessed on a blood sample obtained after a 12-hour fast. All participants were given a questionnaire to answer on various risk factors for osteoporosis. Participants who reported the use of hormone replacement therapy and lipid lowering therapy were excluded. Statistically significant associations were found by SPSS 11.0 and p0,05) higher body mass index is associated with higher bone mineral density at femur neck and lumbar spine (both p values <0,001). Conclusion: There is no significant relation between bone mineral density and lipid levels in postmenopausal women

Using Deep Learning for Mammography Classification

Breast biopsies based on the results of mammography and ultrasound have been diagnosed as benign at a rate of approximately 40 to 60 percent. Negative biopsy results have negative impacts on many aspects such as unnecessary operations, fear, pain, and cost. Therefore, there is a need for a more reliable technique to reduce the number of unnecessary biopsies in the diagnosis of breast cancer. So, computer-aided diagnostic methods are very important for doctors to make more accurate decisions and to avoid unnecessary biopsies. For this purpose, we apply deep learning using Convolutional Neural Networks (CNN) to classify abnormalities as benign or malignant in mammogram images by using two different databases namely, mini-MIAS and BCDR. While mini-MIAS database has valuable information like location of the center of abnormality and radius of the circle that surrounds the abnormality, BCDR database does not have. When we use both dataset as they are, we observe accuracy, precision, recall, and f-score values between around 60% and 72%. In order to improve our results, we take the benefit of preprocessing methods containing cropping, augmentation, and balancing image data. In an effort to crop image data sourced from BCDR, we create a mask to find region of interest. After applying our preprocessing methods over the BCDR dataset, we observe that classification accuracy improves from 65% to around 85%. When we compare the classification accuracy, precision, recall and f-score obtained from the MIAS database with those obtained from the BCDR database we found that after applying preprocessing methods to BCDR dataset, the classification performance become very close to each other for the two datasets

The platelet functions in patients with ankylosing spondylitis: Anti-TNF-alpha therapy decreases the mean platelet volume and platelet mass

WOS: 000274880600007PubMed: 20050759The present study was designed to investigate the interaction between platelet indices (mean platelet volume (MPV), platelet count (PLC) and platelet mass (PLM)), inflammatory markers and disease activity in ankylosing spondylitis (AS) subjects. The effects of anti-TNF-alpha therapy and conventional treatment on platelet indices were also compared. We studied 68 patients with AS (group I, 46 men, age: 36.4 +/- 6.9 years) and as control group 34 age and sex-matched healty subjects. All patients received conventional therapy (CT) at the beginning (Group I). The patients were reevaluated after 3 months according to Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score. Group II consisted of 35 subjects who responded to the CT and continued to take the same therapy for 3 months additionally. Group III consisted of 33 subjects who had a high disease activity score (BASDAI > 4) after 3 months and were accepted refractory to the CT therapy. In Group III the treatment was switched to infliximab and continued for 3 months at the standard intravenous dose. Significantly higher baseline MPV, PLC and PLM was reported as compared to controls decreased by therapy (9.12 +/- 1.20 vs. 8.35 +/- 0.94 fl, p < 0.001, 340 +/- 69 vs. 251 +/- 56 (x10<SU3</SU/ mu L) p < 0.0001, 3096 +/- 736 vs. 2110 +/- 384; p < 0.0001, respectively). In the same way, they were substantially lowered by both treatments in group II and group III. PLC and PLM were positively correlated with WBC and ESR (r : 0.44; p < 0.0001, r : 0.41; p = 0.001, r : 0.52; p < 0.0001, r : 0.41; p = 0.001), respectively) in AS patients. Additionally, MPV and PLM were positively correlated with BASDAI score (r : 0.41; p < 0.001, r = 0.29; p < 0.001 respectively). We have found that increased platelet activity reduced by therapy in AS patients. Additionally, it was correlated with inflammatory markers and disease activity. According to these results, it can be suggested that both anti-TNF-alpha and conventional therapy might contribute to a decrease in the risk of cardiovascular morbidity and mortality in AS patients.</

The platelet indices in patients with rheumatoid arthritis: Mean platelet volume reflects disease activity

WOS: 000274880600006PubMed: 20050760The present study was designed to investigate the interaction between platelet indices, inflammatory markers and disease activity in rheumatoid arthritis (RA) subjects. The effects of anti-TNF-alpha therapy and conventional treatment on platelet indices were also compared. We studied 97 patients with RA (19 men, 78 women: mean age 51 years) and 33 age and sex-matched healthy subjects as a control group. All RA patients were administered conventional therapy. After 3 months of therapy, 35 subjects who had high disease activity score (DAS28 > 5.1) were grouped as non-responders and were administered infliximab as a TNF-alpha blocker at the standard intravenous dose. Responders to the conventional therapy and non-responders were also compared. At baseline white blood cell (WBC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), platelet count and mean platelet volume (MPV) were significantly higher in patients with RA. Mean platelet volume was positively correlated with DAS28 score (r = 0.27; p = 0.007). These markers of inflammation and platelet indices were substantially decreased after therapy. The reductions were similar in responders to conventional therapy and non-responders (TNF alpha group). In conclusion, we found that MPV was correlated with inflammatory markers and disease activity in patients with RA. Both anti-TNF-alpha and conventional therapy decreases markers of inflammation and platelet indices. MPV can reflect both disease activity and response to treatment.</