The acromegaly registry of ten different centers in Turkey.

OBJECTIVES: To describe biochemical and clinical features, and therapeutic outcomes of acromegaly patients in Turkey. METHODS: Retrospective multicenter epidemiological study of 547 patients followed in 10 centers of the Turkish Acromegaly registry. RESULTS: A total of 547 acromegaly patients (55% female) with a median age of 41 was included in this study. Majority of patients had a macroadenoma (78%). Transsphenoidal surgery was performed as primary treatment in 92% of the patients (n = 503). Surgical remission rate was 39% (197/503) in all operated patients. Overall disease control was achieved in 70% of patients. Remission group were significantly older than non-remission group (p = .002). Patients with microadenomas had significantly higher remission rates than patients with macroadenomas (p < .001). Patients with microadenomas were significantly older at the time of diagnosis when compared to patients with macroadenomas (p < .001). Preoperative growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels were significantly lower in the remission group (p < .001). Initial IGF-1 and GH levels were significantly higher in macroadenomas compared to microadenomas (p < .001). Medical treatment was administered as a second-line treatment (97%) in almost all patients without remission. Radiotherapy was preferred in 21% of the patients mostly as a third line treatment. CONCLUSIONS: This is one of the largest real life studies evaluating the epidemiological characteristics and treatment outcomes of patients with acromegaly who were followed in different centers in Turkey. Transsphenoidal surgery in the treatment of acromegaly still remains the most valid method. Medical treatment options may improve long-term disease outcomes in patients who cannot be controlled with surgical treatment (up to 70%)

Психологические факторы развития у студентов опыта межкультурного взаимодействия

Objectives: To describe biochemical and clinical features, and therapeutic outcomes of acromegaly patients in Turkey.Methods: Retrospective multicenter epidemiological study of 547 patients followed in 10 centers of the Turkish Acromegaly registry.Results: A total of 547 acromegaly patients (55% female) with a median age of 41 was included in this study. Majority of patients had a macroadenoma (78%). Transsphenoidal surgery was performed as primary treatment in 92% of the patients (n = 503). Surgical remission rate was 39% (197/503) in all operated patients. Overall disease control was achieved in 70% of patients. Remission group were significantly older than non-remission group (p = .002). Patients with microadenomas had significantly higher remission rates than patients with macroadenomas (p < .001). Patients with microadenomas were significantly older at the time of diagnosis when compared to patients with macroadenomas (p < .001). Preoperative growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels were significantly lower in the remission group (p < .001). Initial IGF-1 and GH levels were significantly higher in macroadenomas compared to microadenomas (p < .001). Medical treatment was administered as a second-line treatment (97%) in almost all patients without remission. Radiotherapy was preferred in 21% of the patients mostly as a third line treatment.Conclusions: This is one of the largest real life studies evaluating the epidemiological characteristics and treatment outcomes of patients with acromegaly who were followed in different centers in Turkey. Transsphenoidal surgery in the treatment of acromegaly still remains the most valid method. Medical treatment options may improve long-term disease outcomes in patients who cannot be controlled with surgical treatment (up to 70%).C1 [Keskin, Caglar; Demir, Ozgur; Sahin, Mustafa; Emral, Rifat; Corapcioglu, Demet] Ankara Univ, Fac Med, Dept Endocrinol & Metab Dis, Ankara, Turkey.[Karci, Alper Cagri; Berker, Dilek] Ankara Numune Training & Res Hosp, Dept Endocrinol & Metab Dis, Ankara, Turkey.[Canturk, Zeynep] Kocaeli Univ, Fac Med, Dept Endocrinol & Metab Dis, Kocaeli, Turkey.[Yaylali, Guzin Fidan; Topsakal, Senay] Pamukkale Univ, Fac Med, Dept Endocrinol & Metab Dis, Denizli, Turkey.[Ersoy, Reyhan] Yildirim Beyazit Univ, Fac Med, Dept Endocrinol & Metab Dis, Ankara, Turkey.[Bayram, Fahri] Erciyes Univ, Fac Med, Dept Endocrinol & Metab Dis, Kayseri, Turkey.[Ertorer, Melek Eda; Bozkirli, Emre; Haydardedeoglu, Filiz] Baskent Univ, Adana Dr Turgut Noyan Training & Res Hosp, Dept Endocrinol & Metab Dis, Adana, Turkey.[Dilekci, Esra Nur Ademoglu] Abant Izzet Baysal Univ, Fac Med, Dept Endocrinol & Metab Dis, Bolu, Turkey.[Ay, Seyid Ahmet] GATA Haydarpasa Training Hosp, Dept Endocrinol & Metab Dis, Istanbul, Turkey.[Cansu, Guven Baris] Eskisehir Yunus Emre Hosp, Dept Endocrinol & Metab Dis, Eskisehir, Turkey

As, Pb, Sb, and Zn transfer from soil to root of wild rosemary: do native symbionts matter?

International audienceThis is an in natura study aimed to determine the potential of Rosmarinus officinalis for phytostabilization of trace metal and metalloid (TMM)-contaminated soils in the Calanques National Park (Marseille, southeast of France). The link between rosemary tolerance/accumulation of As, Pb, Sb, and Zn and root symbioses with arbuscular mycorrhizal (AM) fungi and/or dark septate endophytes (DSE) was examined. Eight sites along a gradient of contamination were selected for soil and root collections. TMM concentrations were analyzed in all the samples and root symbioses were observed. Moreover, in the roots of various diameters collected in the most contaminated site, X-ray microfluorescence methods were used to determine TMM localization in tissues. Rosemary accumulated, in its roots, the most labile TMM fraction in the soil. The positive linear correlation between TMM concentrations in soil and endophyte root colonization rates suggests the involvement of AM fungi and DSE in rosemary tolerance to TMM. Moreover, a typical TMM localization in root peripheral tissues of thin roots containing endophytes forming AM and DSE development was observed using X-ray microfluorescence. Rosemary and its root symbioses appeared as a potential candidate for a phytostabilization process of metal-contaminated soils in Mediterranean area