Photography in architectural education: A tool for assessing social aspects of the built environment

AbstractArchitectural undergraduate education uses visual methods within both teaching and design processes. One method, photography, is mostly used for illustrative documentation. However, using photography more creatively offers rich potential for student engagement with the social environments they work within. In this study, students digitally photographed the built environment of Karaköy, Istanbul and went through a process of keywording and interpretation of their photographs. The results function in a documentary capacity, but also provide insights into the students’ social understandings of the built environment, which, in the context of architectural teaching and learning, has value for both students and instructors

Seismic Behavior of Welded Precast Panel Connections

The behavior of connection between precast panels is important as it controls the failure mode of the shear wall. Therefore, it is aimed to test the behavior of different type of precast panel connections in this study. One monolithic reference model and two precast panel models having different horizontal connection details were produced. The behavior of connections was tested under reversed-cyclic lateral loads. It was concluded that welded connections can be designed in high and normal ductility levels

Repairing and Seismic Strengthening of Damaged Reinforced Concrete Structures with External Steel Shear Walls

In this study, a new strengthening technique for earthquake-damaged reinforced concrete (RC) structures was experimentally investigated. Within the scope of the study, three-dimensional, two-storey RC model was constructed. During the production of this model, some of the common structural inadequacies in existing RC structures were taken into consideration. For this purpose, initially a reference model was exposed to lateral loads up to 1.7 % drift. Then, the damaged structure was repaired with epoxy injection. Finally, the repaired model was strengthened with External Steel Shear Walls (ESSW) and subsequently tested under the same load pattern. Chevron braced system is selected as ESSW. The results show that existing RC structures damaged under earthquake effects can be strengthened rapidly by proposed strengthening technique and the lateral load capacity and stiffness of these structures can be increased significantly

Investigating the effects of appropriate fitting footwear on functional performance level, balance and fear of falling in older adults: A comparative-observational study

The aim of the study was to assess the characteristics of footwear altogether and to compare the effect of appropriate-fitting and ill-fitting footwear on functional performance, balance, and fear of falling (FoF) in older adults. Individuals who wore appropriate-fitting (n = 61) or ill-fitting footwear (n = 92) were enrolled in the study. Footwear was evaluated using the Footwear Assessment Scale (FAS). The participants were assessed using the Berg Balance Scale (BBS) for balance, the Timed Up and Go test for functional performance and the Activities-specific Balance Confidence scale for FoF. Tests were conducted twice for each individual with or without footwear. Differences between the groups were analyzed using the MANOVA for scores of balance, performance and fear of falling and Chi-squared test for homogeneity. The Paired t-test was used to compare test scores with or without footwear. It was concluded that appropriate-fitting footwear improves balance, reduces fear of falling and may affect functional performance positively. ClinicalTrials.gov No: NCT04151654 © 2021 Elsevier Inc

SİC takviyeli̇ alüminyum matrisli kompozit malzemenin farklı kaynak akımları ve türlerinde oluşan mi̇kroyapi ve sertlik özelliklerinin analizi

The welding of metal matrix material reinforced with ceramic particles has some problems such as formation of oxide layer, segregation occurring on welding area, and reaction of ceramic particles with welding bath. The expected mechanical properties cannot be obtained because of these problems. In this study, the weldability of aluminum 2014 alloy reinforced with SiC particles was investigated. MIG welding process was used via using AlSi5 alloy wire at different types and values of welding currents. Samples obtained using manual welding current were compared to those obtained using pulse welding current, in terms of microstructure and distribution of hardness. The effects of different types and values of welding currents on the microstructure and hardness distribution were examined. It was obtained that the welding of the composite with aluminum 2014 alloy matrix reinforced with SiC particles via using of pulse current, potential formation of segregation was prevented and microstructural properties were improved

Sustained release silk fibroin discs: Antibody and protein delivery for HIV prevention

With almost 2 million new HIV infections worldwide each year, the prevention of HIV infection is critical for stopping the pandemic. The only approved form of pre-exposure prophylaxis is a costly daily pill, and it is recognized that several options will be needed to provide protection to the various affected communities around the world. In particular, many at-risk people would benefit from a prevention method that is simple to use and does not require medical intervention or a strict daily regimen. We show that silk fibroin protein can be formulated into insertable discs that encapsulate either an antibody (IgG) or the potent HIV inhibitor 5P12-RANTES. Several formulations were studied, including silk layering, water vapor annealing and methanol treatment to stabilize the protein cargo and impact the release kinetics over weeks. In the case of IgG, high concentrations were released over a short time using methanol treatment, with more sustained results with the use of water vapor annealing and layering during device fabrication. For 5P12-RANTES, sustained release was obtained for 31 days using water vapor annealing. Further, we show that the released inhibitor 5P12-RANTES was functional both in vitro and in ex vivo colorectal tissue. This work shows that silk fibroin discs can be developed into formidable tools to prevent HIV infection

Potential role of the geriatric nutritional risk index as a novel risk factor for the development of non-valvular atrial fibrillation in patients with heart failure

PURPOSE: The geriatric nutritional risk index (GNRI) is a simple and objective nutritional assessment tool for elderly patients. Lower GNRI values are associated with a worse prognosis in heart failure with reduced ejection fraction (HFrEF). Our aim is to investigate the relationship between malnutrition and follow-up cardiovascular (CV) events in HFrEF. METHODS: A retrospective study was performed on 362 patients with HFrEF. The baseline GNRI was calculated at the first visit. The patients were divided into three groups according to the GNRI: >98, no-risk group; 92 to <= 98, low risk group; 82 to <92, moderate-to-high-risk group. The study endpoint was a composite of follow-up CV events, including all-cause mortality, non-valvular atrial fibrillation (NVAF) , need for cardioverter defibrillator (ICD) therapy, HfrEF-related hospitalizations and need for percutaneous coronary interventions (PCIs). RESULTS: Follow-up data showed that the group with moderate-to-high risk had a significantly higher incidence of NVAF, PCIs and all-cause mortality compared to other groups (p0.05). Mean GNRI value was 83.3 in NVAF patients and 101.1 in patients without NVAF (p<0.001). Kaplan Meier survival analysis showed that patients from the group with moderate-to-high risk had a significantly worse survival rate (p < 0.001). In the multivariate Cox regression analysis, the group with moderate-to-high risk (HR =3.872) and ICD implantations (HR = 4.045) were associated with increased mortality. CONCLUSION: The GNRI value may have a potential role for predicting future events, especially NVAF in patients with HfrEF

NF-κB-mediated effects on behavior and cartilage pathology in a non-invasive loading model of post-traumatic osteoarthritis

OBJECTIVE: This study aimed to examine the temporal activation of NF-κB and its relationship to the development of pain-related sensitivity and behavioral changes in a non-invasive murine knee loading model of PTOA. METHOD: Following knee injury NF-κB activity was assessed longitudinally via in vivo imaging in FVB. Cg-Tg (HIV-EGFP,luc)8Tsb/J mice. Measures of pain-related sensitivity and behavior were also assessed longitudinally for 16 weeks. Additionally, we antagonized NF-κB signaling via intra-articular delivery of an IκB kinase two antagonist to understand how local NF-κB inhibition might alter disease progression. RESULTS: Following joint injury NF-κB signaling within the knee joint was transiently increased and peaked on day 3 with an estimated 1.35 p/s/cm CONCLUSION: These findings underscore the development of behavioral changes in this non-invasive loading model of PTOA and their relationships to NF-κB activation and pathology. They also highlight the potential chondroprotective effects of NF-κB inhibition shortly following joint injury despite limitations in preventing the long-term development of joint degeneration in this model of PTOA

COPE-SMARTER – A decision support system for analysing the challenges, opportunities and policy initiatives: A case study of electric commercial vehicles market diffusion in Denmark

Stakeholder's strategies in encouraging wide-scale market penetration depend on their perceptions. This study focuses on perceptions of Danish practitioners in policy-making organizations regarding the perceived challenges, opportunities and policy initiatives for the majority-market adoption of electric commercial vehicles (ECVs) in commercial sector in Denmark. We propose a new four-step expert-based technique, named COPE-SMARTER, for evaluating the market diffusion of environmental friendly technologies by combining SWOT analysis and multi-criteria decision analysis (MCDA) techniques. We focus on the perceptions regarding: (i) the potential promotional strength of motivators for ECV market penetration, (ii) the severity of the technological, financial, physical and operational challenges, (iii) the efficiency of policy initiatives in encouraging the market diffusion of ECVs, (iv) the expected market penetration rates for ECVs by target year. The results show the strength of the COPE-SMARTER approach in generating a clear, coherent, and tractable evaluation. Severe challenges are financial, operational and technological, with high purchase prices being by far the most severe. The opportunities are financial and environmental, with overall savings in the long-term as the opportunity with the highest promotional strength. Effective policy initiatives are low registration fee for ECVs, state subsidies for the purchase or use of ECVs, and emission-based taxes

30-day morbidity and mortality of sleeve gastrectomy, Roux-en-Y gastric bypass and one anastomosis gastric bypass: a propensity score-matched analysis of the GENEVA data

Background: There is a paucity of data comparing 30-day morbidity and mortality of sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), and one anastomosis gastric bypass (OAGB). This study aimed to compare the 30-day safety of SG, RYGB, and OAGB in propensity score-matched cohorts. Materials and methods: This analysis utilised data collected from the GENEVA study which was a multicentre observational cohort study of bariatric and metabolic surgery (BMS) in 185 centres across 42 countries between 01/05/2022 and 31/10/2020 during the Coronavirus Disease-2019 (COVID-19) pandemic. 30-day complications were categorised according to the Clavien–Dindo classification. Patients receiving SG, RYGB, or OAGB were propensity-matched according to baseline characteristics and 30-day complications were compared between groups. Results: In total, 6770 patients (SG 3983; OAGB 702; RYGB 2085) were included in this analysis. Prior to matching, RYGB was associated with highest 30-day complication rate (SG 5.8%; OAGB 7.5%; RYGB 8.0% (p = 0.006)). On multivariate regression modelling, Insulin-dependent type 2 diabetes mellitus and hypercholesterolaemia were associated with increased 30-day complications. Being a non-smoker was associated with reduced complication rates. When compared to SG as a reference category, RYGB, but not OAGB, was associated with an increased rate of 30-day complications. A total of 702 pairs of SG and OAGB were propensity score-matched. The complication rate in the SG group was 7.3% (n = 51) as compared to 7.5% (n = 53) in the OAGB group (p = 0.68). Similarly, 2085 pairs of SG and RYGB were propensity score-matched. The complication rate in the SG group was 6.1% (n = 127) as compared to 7.9% (n = 166) in the RYGB group (p = 0.09). And, 702 pairs of OAGB and RYGB were matched. The complication rate in both groups was the same at 7.5 % (n = 53; p = 0.07). Conclusions: This global study found no significant difference in the 30-day morbidity and mortality of SG, RYGB, and OAGB in propensity score-matched cohorts