Assessing the correlation between FDG PET findings of IDC breast carcinoma and histopathology of coexisting ductal carcinoma in-situ

Background: Ductal carcinoma in-situ (DCIS) often coexists with invasive ductal carcinoma (IDC) of the breast. DCIS is considered as a non-obligate precursor of IDC when both coexist. 18F-fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG PET/CT) imaging is commonly used in the staging and follow-up assessment of breast cancer. In this study, we aimed to assess if there is any correlation between primary tumor PET and histopathology findings and histopathological features of the coexisting DCIS. Material and methods: FDG PET/CT images and histopathology results of the patients with newly diagnosed breast cancer (IDC) with coexisting DCIS were analyzed in this retrospective study. The grade and size of the primary tumor and histopathological features of the coexisting DCIS (nuclear grade and architectural pattern) were obtained from the postoperative histopathology results. Maximum standardized uptake values (SUV: SUVmax and SULmax) of the primary tumor normalized by weight and lean body mass were measured. Statistical analysis was performed to assess the correlation between various parameters of IDC and DCIS. Results: This study included sixty-two (62) patients with IDC-DCIS. Primary tumor grade was significantly correlated and associated with the nuclear grade of the coexisting DCIS (polychoric correlation r = 0.736, and Fisher exact test, PV < 0.001, respectively). Primary tumor SUV was not correlated with the nuclear grade and architectural pattern of the coexisting DCIS (polyserial correlation r = 0.172, PV = 0.155, and Point Bi-Serial correlation r = –0.009, PV = 0.955, respectively). Median primary tumor size was marginally significantly different among DCIS nuclear grades but it was not significantly different in comedo and non-comedo cases (Kruskal-Wallis test PV = 0.053, and Mann-Whitney U test PV = 0.890, respectively). Conclusions: Primary tumor grade is correlated with the nuclear grade of the coexisting DCIS. SUV of primary tumor does not seem to be correlated with the histopathological features of coexisting DCIS (nuclear grade and architectural pattern) but this may be further studied in a larger number of patients

Diagnostic performance of low-dose chest CT to detect COVID-19: A Turkish population study

PURPOSEWe aimed to evaluate the diagnostic performance of low-dose chest computed tomography (CT) in patients under investigation for coronavirus disease 2019 (COVID-19).METHODSThis retrospective study included 330 patients suspected of having COVID-19 from March 15 to April 16, 2020. We examined 306 patients upon initial presentation using both CT and real-time reverse-transcriptase polymerase-chain-reaction (rRT-PCR). The diagnostic performance of CT was calculated using rRT-PCR as a reference. Clinical and laboratory data, CT characteristics, and lesion distribution were assessed for patients with a confirmed diagnosis via rRT-PCR.RESULTSA total of 250 patients were finally diagnosed with COVID-19. Clinical and laboratory findings included myalgia or fatigue (76%), fever (64.8%), dry cough (60.8%), elevated levels of C-reactive protein (86.4%), procalcitonin (62%), and D-dimer (58.2%), increased neutrophil-lymphocyte ratio (NLR) (54.8%), and lymphopenia (34%). Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the initial CT scan were 90.4% (95% IC, 86%–93%), 64.2% (95% IC, 50%–76%), 91.8% (95% IC, 88%–94%), and 60% (95% IC, 49%–69%), respectively. The percentage of patients diagnosed on the initial rRT-PCR test was 51.6% (n=129). Most frequent CT characteristics of COVID-19 in the subgroup of rRT-PCR-positive patients were multiple lesion (97.4%, n=220), followed by bilateral involvement (88.5%, n=200), peripheral distribution (74.3%, n=168), ground-glass opacity (GGO) (69.2%, n=157), subpleural curvilinear opacity (41.6%, n=104), and mixed GGOs (27.6%, n=67).CONCLUSIONrRT-PCR may produce initial false negative results. For this reason, typical CT findings for COVID-19 should be known especially by radiologists. We suggest that patients with typical CT findings but negative rRT-PCR results should be isolated, and rRT-PCR should be repeated to avoid misdiagnosis

Monochorionic triamniotic triplet pregnancy with a co-triplet fetus discordant for congenital cystic adenomatoid malformation of the lung

BACKGROUND: Spontaneous monochorionic triamniotic pregnancy is rare and is at increased risk for pregnancy complications. The presence of an anomalous fetus further complicates the management. CASE PRESENTATION: We present a case of monochorionic triamniotic triplet pregnancy diagnosed at 15 weeks of gestation with one fetus having developed a multicystic lung lesion, suggestive of congenital cystic adenomatoid malformation (CCAM). At 24 weeks, the largest cyst measured 10 mm in diameter. We managed the pregnancy conservatively and delivered three live male fetuses with birth weights 1560 g, 1580 g and 1590 g at 35 weeks of gestation. Two newborns were admitted to the neonatal intensive care unit with respiratory distress, the third one died due to sepsis 7 days postpartum. One of the newborns was discharged healthy at 24 days postpartum. The newborn with CCAM developed a pneumothorax on the right side, recovered after treatment, and was discharged after one month. Computerized tomography (CT) of the infant at 3 months demonstrated two cystic lesions in the middle lobe of the right lung measuring 25 mm and 15 mm. A repeat CT of the infant at 6 months showed a 30 mm solitary cystic mass. CONCLUSION: Monochorionic triamniotic triplet pregnancy with a co-triplet fetus discordant for CCAM, present rarely and can be managed conservatively. These findings may help in decision making and counselling of parents

a composite laminate veneer technique for diastema closure a report of ten cases

Aim: Diastemas can be treated using periodontal, surgical, orthodontic, or prosthetic procedures. Composite laminate veneers can be applied to reduce or eliminate diastemas and represent a good aesthetic non-invasive alternative for these patients. This study presents the treatment results of 10 patients with diastemas between the anterior teeth of the maxilla and mandible with composite veneers. Methodology: Ten patients with diastemas between the anterior maxillary and mandibular teeth complaining of esthetic problems were treated at the Department of Operative Dentistry, University of Dicle. The periodontal health of the patients was acceptable and no caries were detected. Patients were informed of the treatment choices and composite resin veneers were selected as the better approach for each case. The presence of a diastema causes esthetic problems, especially in adolescents. Prosthetic and conservative methods are usually used to treat diastemas because these approaches are minimally invasive. The direct laminate technique has the advantages of low cost, treatment reversibility, and easy repair of the restoration intraorally. The direct composite laminate technique has become more effective because of improvements in adhesive dentistry. Conclusion: This study describes a direct composite laminate technique for the restoration of the anterior teeth of 10 patients with diastemas. These restorations were conservative and provide an inexpensive, one-visit aesthetic treatment for anterior teeth. How to cite this article: Bahşi E, Callea M, İnce B, Montanari M, Dallı M, Batteli F, Akdoğan M, Gabriella C, Toptancı İR, Gabriela P, Yavuz İ. A Composite Laminate Veneer Technique for Diastema Closure: A Report of Ten Cases. Int Dent Res 2012;2:67-74. Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English

Herkesin demokrasisinden bizim demokrasiye: 16 Nisan referandumunun birinci yılında bir değerlendirme

Abstract Not Availabl

Hidrolik Sistemlerdeki 90° Bükümlü Borularda Oluşan Basınç Kayıplarının Sayısal Olarak İncelenmesi

Hidrolik sistemler, günümüzde birçok alanda kullanılmaktadır. Özellikle yüksek güç ihtiyacı olan işlerde tercih edilmektedir. Hidrolik sistemler temelde birkaç basit devre elemanı ve bu elemanları birbirlerine bağlayan devre iletim parçalarından, iletim ve bağlantı parçaları ise borular, hortumlar, rakor, dirsek gibi bağlantı elemanlarından oluşmaktadır. Hidrolik devrelerde enerji tasarrufu ve düşük maliyetli bir sistem oluşturabilmek için minimum basınç kaybı oluşturacak şekilde devrenin tasarlanması gerekmektedir. İletim boruları basınç kaybı yaratan önemli devre elemanlarının başında gelmektedir. Bu çalışmada 90° bükülmüş bir hidrolik devre borusunda meydana gelen basınç kayıpları sayısal olarak hesaplanmıştır. İlk olarak büküm yarıçapının basınç kaybına etkisi, daha sonra büküm sırasında oluşacak ovallik (büküm sırasında oluşan daralmalar) incelenmiştir. Sonuç olarak; büküm yarı çapının artmasının basınç kayıplarını azalttığı, ovalitenin yaklaşık %15’e kadar çok fazla bir basınç kaybı oluşturmadığı ancak bu değerden sonra basınç kayıplarının arttığı tespit edilmişti

Neuropsychiatric disorders and risk factors in carbon monoxide intoxication

Kandis, Hayati/0000-0001-9151-6050WOS: 000291038300002PubMed: 21088053Neuropsychiatric sequelae may be observed in the late phases of carbon monoxide (CO) intoxication. Establishing a link between CO-related neuropsychiatric disorders and associated risk factors may decrease morbidity and mortality by means of appropriate treatment and counseling. The aim of the present study was to determine the relationship between neuropsychiatric outcomes of CO intoxication and demographic and clinical variables. Thirty patients who presented with CO intoxication and had no known neuropsychiatric disease, and 30 healthy controls were included. Physical examinations and laboratory tests were performed. Following the 1st therapy, they underwent mental and psychiatric tests 5 times (the time of discharge, during the 1st week, and during the 1st, 3rd, and 6th months). They underwent cerebral magnetic resonance imaging (MRI) at the end of the 1st month. They were evaluated by cognitive function tests at the 6th month. Lesions relevant to CO intoxication were detected in 46.7% of the patients via cranial computed tomography and in 13.3% via MRI. Evaluation of psychiatric tests revealed a clear decrease in cognitive functions, such as immediate memory, learning, reaching the criterion, spontaneous recall, attention, visual memory, and logical memory. It was found that the patients had anxiety within the 1st month, and the frequency of anxiety reached to the value of the control group by the end of the 6th month. In conclusion, we suggested that CO intoxication might lead to neuropsychiatric disorders. Our results emphasized that in addition to standard treatment, neuropsychiatric evaluation should also be performed in patients with CO intoxication