Effect of implant strategy and Optaflexx administration on feedlot performance and skeletal muscle β-adrenergic receptor and insulin-like growth factor I mRNA abundance

Feedlot heifers (1,147) weighing 622 lb were used to evaluate the effects of implant strategy and Optaflexx administration. Implant treatments included Revalor-200 (R200) at arrival, or Revalor-IH at arrival and reimplantation with Finaplix-H on day 58 (RF). Optaflexx (200 mg/heifer daily of ractopamine-HCl) was fed the last 28 days. Treatments were randomly assigned to 16 pens. After 182 days, heifers were slaughtered, at which time carcass data were obtained and semimembranosus muscle tissue was excised for RNA isolation. Optaflexx administration significantly increased average daily gain (0.7 lb/day), feed efficiency (3%), hot carcass weight (10.5 lb), and ribeye area (0.42 square inches); decreased back fat thickness; and improved yield grade. There was no significant treatment effect on the expression of β1-adrenergic receptor (AR) mRNA, but there was a tendency for Optaflexx feeding to increase β2-AR mRNA concentrations. For β3-AR mRNA, Optaflexx treatment numerically increased β3-AR mRNA in heifers implanted with R200, but significantly decreased expression in heifers implanted with RF. Optaflexx also significantly decreased IGF-I mRNA in heifers implanted with RF, but numerically increased IGF-I mRNA in heifers implanted with R200. This data aids our understanding of the interaction between steroidal implants and Optaflexx in feedlot heifers. Knowledge about the modes of action of various growth promotants will aid in designing growth promotion strategies to enhance the efficiency of lean tissue deposition in feedlot cattle

A Hybrid Distributed Architecture for Indexing

This paper presents a hybrid scavenger grid as an underlying hardware architecture for search services within digital libraries. The hybrid scavenger grid consists of both dedicated servers and dynamic resources in the form of idle workstations to handle medium- to large-scale search engine workloads. The dedicated resources are expected to have reliable and predictable behaviour. The dynamic resources are used opportunistically without any guarantees of availability. Test results confirmed that indexing performance is directly related to the size of the hybrid grid and intranet networking does not play a major role. A system-efficiency and cost-effectiveness comparison of a grid and a multiprocessor machine showed that for workloads of modest to large sizes, the grid architecture delivers better throughput per unit cost than the multiprocessor, at a system-efficiency that is comparable to that of the multiprocessor

Understanding Youth Sport Coaches' Perceptions of Evidence-Based Injury-Prevention Training Programs: A Systematic Literature Review

Objective: To systematically review and summarize the knowledge, attitudes, beliefs, and contextual perceptions of youth sport coaches toward injury-prevention training programs by using the Theoretical Domains Framework to guide the organization of results. Data Sources: Systematic searches of PubMed and Google Scholar were undertaken in November 2021. Study Selection: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol was followed. Results were limited to full-text articles that were published in peer-reviewed journals and printed in English. Additional studies were added after a citation search of included studies. Studies were eligible for inclusion if researchers evaluated youth sport coaches' knowledge, beliefs, contextual perceptions, or all 3 of anterior cruciate ligament injury-prevention training programs. Data Extraction: Data charting was performed by 1 author and confirmed by a separate author. Data Synthesis: Of the 1194 articles identified, 19 were included in the final sample. Among articles in which researchers assessed knowledge (n = 19), coaches' awareness of the existence and components of injury-prevention training programs was inconsistent. Among articles in which researchers assessed beliefs (n = 19), many coaches had positive attitudes toward injury-prevention training programs, but few believed youth athletes are at a high risk of injury. Among articles in which researchers assessed contextual perceptions (n = 13), many coaches did not feel they had access to information about injuryprevention training programs and cited a lack of time, space, support, and other resources as barriers to implementation. Conclusions: Our findings support the need for programs, protocols, and policies to enhance knowledge of and support for youth sport coaches who wish to implement injury-prevention training programs. A gap exists in the research about addressing the needs of youth sport coaches in the United States high school sports setting. The use of multilevel implementation science frameworks (such as the Theoretical Domains Framework) will be beneficial for identifying constructs that affect implementation and developing train-the-trainer programming to meet the needs of individual youth sport coaches

Experimental Study of the Shortest Reset Word of Random Automata

In this paper we describe an approach to finding the shortest reset word of a finite synchronizing automaton by using a SAT solver. We use this approach to perform an experimental study of the length of the shortest reset word of a finite synchronizing automaton. The largest automata we considered had 100 states. The results of the experiments allow us to formulate a hypothesis that the length of the shortest reset word of a random finite automaton with $n$ states and 2 input letters with high probability is sublinear with respect to $n$ and can be estimated as $1.95 n^{0.55}.

Active Brownian Particles. From Individual to Collective Stochastic Dynamics

We review theoretical models of individual motility as well as collective dynamics and pattern formation of active particles. We focus on simple models of active dynamics with a particular emphasis on nonlinear and stochastic dynamics of such self-propelled entities in the framework of statistical mechanics. Examples of such active units in complex physico-chemical and biological systems are chemically powered nano-rods, localized patterns in reaction-diffusion system, motile cells or macroscopic animals. Based on the description of individual motion of point-like active particles by stochastic differential equations, we discuss different velocity-dependent friction functions, the impact of various types of fluctuations and calculate characteristic observables such as stationary velocity distributions or diffusion coefficients. Finally, we consider not only the free and confined individual active dynamics but also different types of interaction between active particles. The resulting collective dynamical behavior of large assemblies and aggregates of active units is discussed and an overview over some recent results on spatiotemporal pattern formation in such systems is given.Comment: 161 pages, Review, Eur Phys J Special-Topics, accepte

Comparing emission- and absorption-based gas-phase metallicities in GRB host galaxies at z = 2−4 using JWST

© 2024 The Author(s). Published by Oxford University Press on behalf of Royal Astronomical Society. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/Much of what is known of the chemical composition of the universe is based on emission line spectra from star-forming galaxies. Emission-based inferences are, nevertheless, model-dependent and they are dominated by light from luminous star-forming regions. An alternative and sensitive probe of the metallicity of galaxies is through absorption lines imprinted on the luminous afterglow spectra of long gamma ray bursts (GRBs) from neutral material within their host galaxy. We present results from a JWST/NIRSpec programme to investigate for the first time the relation between the metallicity of neutral gas probed in absorption by GRB afterglows and the metallicity of the star-forming regions for the same host galaxy sample. Using an initial sample of eight GRB host galaxies at z = 2.1–4.7, we find a tight relation between absorption and emission line metallicities when using the recently proposed $\hat{R}$ metallicity diagnostic (±0.2 dex). This agreement implies a relatively chemically homogeneous multiphase interstellar medium and indicates that absorption and emission line probes can be directly compared. However, the relation is less clear when using other diagnostics, such as R23 and R3. We also find possible evidence of an elevated N/O ratio in the host galaxy of GRB 090323 at z = 4.7, consistent with what has been seen in other z > 4 galaxies. Ultimate confirmation of an enhanced N/O ratio and of the relation between absorption and emission line metallicities will require a more direct determination of the emission line metallicity via the detection of temperature-sensitive auroral lines in our GRB host galaxy sample.Peer reviewe