Risk Factors Associated with Adverse Fetal Outcomes in Pregnancies Affected by Coronavirus Disease 2019 (COVID-19): A Secondary Analysis of the WAPM study on COVID-19

To evaluate the strength of association between maternal and pregnancy characteristics and the risk of adverse perinatal outcomes in pregnancies with laboratory confirmed COVID-19. Secondary analysis of a multinational, cohort study on all consecutive pregnant women with laboratory-confirmed COVID-19 from February 1, 2020 to April 30, 2020 from 73 centers from 22 different countries. A confirmed case of COVID-19 was defined as a positive result on real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of nasal and pharyngeal swab specimens. The primary outcome was a composite adverse fetal outcome, defined as the presence of either abortion (pregnancy loss before 22 weeks of gestations), stillbirth (intrauterine fetal death after 22 weeks of gestation), neonatal death (death of a live-born infant within the first 28 days of life), and perinatal death (either stillbirth or neonatal death). Logistic regression analysis was performed to evaluate parameters independently associated with the primary outcome. Logistic regression was reported as odds ratio (OR) with 95% confidence interval (CI). Mean gestational age at diagnosis was 30.6\ub19.5 weeks, with 8.0% of women being diagnosed in the first, 22.2% in the second and 69.8% in the third trimester of pregnancy. There were six miscarriage (2.3%), six intrauterine device (IUD) (2.3) and 5 (2.0%) neonatal deaths, with an overall rate of perinatal death of 4.2% (11/265), thus resulting into 17 cases experiencing and 226 not experiencing composite adverse fetal outcome. Neither stillbirths nor neonatal deaths had congenital anomalies found at antenatal or postnatal evaluation. Furthermore, none of the cases experiencing IUD had signs of impending demise at arterial or venous Doppler. Neonatal deaths were all considered as prematurity-related adverse events. Of the 250 live-born neonates, one (0.4%) was found positive at RT-PCR pharyngeal swabs performed after delivery. The mother was tested positive during the third trimester of pregnancy. The newborn was asymptomatic and had negative RT-PCR test after 14 days of life. At logistic regression analysis, gestational age at diagnosis (OR: 0.85, 95% CI 0.8-0.9 per week increase; p<0.001), birthweight (OR: 1.17, 95% CI 1.09-1.12.7 per 100 g decrease; p=0.012) and maternal ventilatory support, including either need for oxygen or CPAP (OR: 4.12, 95% CI 2.3-7.9; p=0.001) were independently associated with composite adverse fetal outcome. Early gestational age at infection, maternal ventilatory supports and low birthweight are the main determinants of adverse perinatal outcomes in fetuses with maternal COVID-19 infection. Conversely, the risk of vertical transmission seems negligible

Hepatobiliary scintigraphy to defect duodenogastric reflux - Intravenous administration of Tc-99m pertechnetate to define the location of the stomach

WOS: 000168214800025PubMed ID: 11290908

Hepatobiliary scintigraphy to detect duodenogastric reflux: Intravenous administration of Tc-99m pertechnetate to define the location of the stomach

PubMedID: 11290908A 65-year-old man who had a cholecystectomy 20 years previously and a recent 6-month history of right upper abdominal pain that spread to the back was evaluated for duodenogastric reflux by hepatobiliary scintigraphy. Abnormal activity in two frames suggested duodenogastric reflux. To determine file location of the stomach, intravenous administration of Tc-99m pertechnetate was administered after the hepatobiliary scan. This is a simple method that includes only the intravenous administration of 3 to 5 mCi (111 MBq) Tc-99m pertechnetate and is a good alternative to the oral use of technetium agents, which have a carefully calculated dose adjustment to avoid scatter, and dual-isotope imaging, which requires a second isotope

ON THE GEOMETRY OF CLOSED TIMELIKE RULED SURFACES IN DUAL LORENTZIAN SPACE

Abstract: In this paper, a dual timelike curve c(t) which is a Lorentzian spherical indicatrix of a timelike closed ruled surface − → V * 1 (t) with a real parameter t, two frames which moves respect to D * and related to a timelike closed ruled surface drawn by a timelike vector − → V 1 (t), and a timelike vector − → V which is fixed in the frame D are considered; and dual integral invariants of the timelike closed ruled surfaces which correspond to the dual timelike closed curves drawn by the vectors − → V , − → V 1 and − → V * 1 are studied; and it is found same relations among the dual integral invariants of the timelike closed ruled surfaces which correspond to the dual timelike closed curves drawn by the timelike vectors − → V , − → V 1 and − → V * 1 . In addition, these results are carried to the Lorentzian line space R 3 1 and give some theorems by means of Study&apos;s mapping

Assessment of the optimal time interval and background region of interest in measurement of relative renal function in Tc-99m EC renography

WOS: 000170528300557

The conditions for which geometric mean method revealed more accurate calculation of relative renal function in DMSA scintigraphy

Annual Congress of the European-Association-of-Nuclear-Medicine -- SEP 04-08, 2004 -- Helsinki, FINLANDWOS: 000223419901071…European Assoc Nucl Me

Assessment of the optimal time interval and background region of interest in the measurement of differential renal function in Tc-99m-EC renography

PubMedID: 15462404Background: Differential renal function (DRF) measurements are routinely corrected for background, which mainly affects the reproducibility and accuracy of the measurement. The present study was conducted to identify the most appropriate background ROI and optimal time interval in the calculation of DRF for EC renography. Materials and Methods: Nineteen patients were studied. For determination of DRF in EC renography, the selected time intervals were 0.5-1.5; 0.5-2; 1-2; 1.5-2.5; 2-3 min, and the background ROI types were inferolateral crescent, lateral crescent, and perirenal shaped. The reference DRF was obtained through DMSA study. For low functioning kidney of each patient, relative uptake differences between the DMSA and EC scans were calculated. Then, the mean differences and the standard deviations were found. Results: The highest correlation was between the DRF values obtained using inferolateral background ROI in 0.5-2 minutes of EC scintigraphy and the DRF values obtained through posterior DMSA images (r = 0.9889). However, there were no statistically significant differences between the mean DRF values obtained for each time interval with each ROI type (p > 0.05). For all the time intervals and background ROIs, the mean of the differences was <0.9%. In conclusion, in obtaining comparable DRF values from EC and DMSA studies, none of the background types proved superior. Also our research for optimal time interval showed that EC scintigraphy underestimates the DRF when compared to DRF obtained from DMSA study. The DRF has a tendency to decrease as the later time intervals are used. The time intervals less than 2.5 minutes show lower underestimation of DRF values

The conditions for which the geometric mean method revealed a more accurate calculation of relative renal function in Tc-99m-DMSA scintigraphy

WOS: 000227263200011PubMed ID: 15657508Aims (1) To compare the results of calculating relative renal function (RRF) by using only posterior images (POST) with the geometric mean (GM) through both anterior and posterior imaging on dimercaptosuccinic acid (DMSA) scintigraphy. (2) To determine whether there was an age-related difference between them and whether some renal pathologies or asymmetrical renal function cause an error in the RRF calculation by using posterior images only. Methods Eight hundred and ninety-one DMSA scans were studied retrospectively. The patients were divided into five age groups: group I, less than or equal to 2 years; group II, > 2 to less than or equal to 5 years; group III > 5 to less than or equal to 10 years; group IV, > 10 to less than or equal to 18 years; and group V, > 18 years. The RRF of the right kidney (RKF) was calculated from the POST and GM counts. The differences between RKFGM and RKFPOST were calculated in all the patients. Results Among the 891 patients, nine had malrotated or malpositioned kidneys, 373 had renal pathologies of pyelonephritis, hydronephrosis, cortical scarring and atrophy, 247 had asymmetrically functioning kidneys and 509 had normal kidneys. When the patients were analysed according to different age groups, significant differences were found between all groups (P 0.05) with the Ftest. The clinically meaningful RRF variance ( greater than or equal to 5 % difference between two methods) rate differed significantly between groups I, II and III, and groups IV and V (chi-squared test, P < 0.05). In patients age

Incidental detection of a vertebral body hemangioma on three-phase bone scintigraphy

WOS: 000083936200028PubMed ID: 10595494