Emerging Spatio-temporal Hot Spot Analysis of Beijing Subsidence Trend Detection Based on PS-InSAR

Scholars have done a lot of research on urban settlement, but it is difficult to give consideration to the temporal and spatial attributes of settlement at the same time in its display and analysis. Most of them focused on the analysis of regional settlement, single point settlement curve and settlement rate map at a certain time, but few combined time and space for collaborative analysis. Therefore, in this paper, 32 scenes Sentinel-1B SAR data are used to obtain settlement data of Beijing via PS-InSAR method. Secondly, combined with the temporal and spatial attributes of settlement results, the subsidence law revealed by using spatio-temporal cube slicing and attribute filtering. Finally, subsidence development trend and the detection of abnormal subsidence are explored by emerging hot spots (ESH) analysis. The experimental results show that the settlement funnel center in Beijing is mainly concentrated near the junction of Chaoyang district and Tongzhou district. The settlement range tends to expand. There are several local continuous subsidence areas in the settlement oscillating area. Spatio-temporal analysis makes the development trend of urban settlement more intuitive. Emerging hotspot analysis combined with Getis-Ord Gi* statistics and Mann-Kendall trend test could more effectively analyze the settlement trend of the study area and detect new potential settlement centers, so that to provide auxiliary decision-making for urban safety early warning and city development

Occurrence and characteristics of rock glaciers in the Poiqu River basin – Central Himalaya

Funding: This study was conducted within the framework of the Dragon 4 program funded by ESA (4000121469/17/I-NB) and further supported by the Strategic Priority Research Program of Chinese Academy of Sciences (XDA20100300), Swiss National Science Foundation (Grant No. IZLCZ2_169979/1) and the Hong Kong Research Grants Council (CUHK14303417 and HKPFS PF16-03859).Rock glaciers are important to study as they can be of hydrological importance and could have serious hazard potentials. Existing investigations about rock glaciers in High Mountain Asia indicate that the landforms are abundant, but information is still rare for large parts of the region. We compiled a rock glacier inventory for the Poiqu River basin, Central Himalaya. The mapping was conducted using very high-resolution Pléiades imagery and digital elevation model and imagery available from Google Earth. Rock glaciers were classified either active or inactive based on interferograms generated using ALOS-1 PALSAR data. Moreover, we developed a new method to automatically map the frontal slopes of the rock glaciers to investigate their activity. The results reveal 370 rock glaciers including 148 active and 222 inactive ones. We found nine rock glaciers damming lakes, three of which could be potentially dangerous. The overall rock glacier area is about 20.9 km which is more than 10% of the glacier area. The two largest rock glaciers cover 0.50 and 0.45 km². The rock glaciers are located at elevations between ~4000 and ~6000 m above sea level (mean elevations ~5100 m). Most of the rock glaciers face towards East and Southwest. The mean overall slope is 19.3° with the active ones being on average only slightly steeper (active: 19.7°, inactive: 19.0°). Their frontal slopes, however, are clearly steeper. The availability of very high-resolution data was key to generate a rock glacier inventory and allowed assessment of the rock glacier characteristics with high accuracy.PreprintNon peer reviewe

M2-Polarized tumor-associated macrophages are associated with poor prognoses resulting from accelerated lymphangiogenesis in lung adenocarcinoma

OBJECTIVES: Tumor-associated macrophages have been implicated in promoting tumor growth, progression and metastasis. However, the activated phenotype (M1 or M2) of tumor-associated macrophages remains unknown in solid tumors. Therefore, this study examined the density and prognostic significance of M2-polarized tumor-associated macrophages in lung adenocarcinoma. METHODS: Tumor specimens from 65 lung adenocarcinoma patients were assessed by ELISA for Th1/Th2 cytokine concentrations. The activated phenotype (M1 or M2) of tumor-associated macrophages was determined utilizing immunofluorescence staining. Additionally, to evaluate lymphangiogenesis, peritumoral lymphatic microvessel density was measured using D2-40. The correlation between tumor-associated macrophage subtype and overall patient survival was analyzed using the Kaplan-Meier method and compared using the log-rank test. RESULTS: A shift toward Th2 cytokine expression was detected within lung adenocarcinoma microenvironments. Approximately 79.71±16.27% of tumor-associated macrophages were M2 polarized; the remaining 20.35±5.31% were M1 polarized. The infiltration of M2-polarized macrophages was significantly associated with P-TNM staging and lymph node metastasis. The peritumoral lymphatic microvessel density was significantly higher in the high M2-polarized tumor-associated macrophage group than in the low M2-polarized tumor-associated macrophage group. A significant difference in overall patient survival was detected not only between patients with tumors with high and low macrophage counts but also between patients with tumors with high and low counts of M2-polarized macrophages. CONCLUSION: Tumor-associated macrophages in lung adenocarcinoma have an M2-polarized subtype and are associated with poor prognoses, perhaps resulting from accelerated lymphangiogenesis and lymph node metastasis

M2-polarized macrophages promote metastatic behavior of Lewis lung carcinoma cells by inducing vascular endothelial growth factor-C expression

OBJECTIVES: Tumor-associated macrophages that generally exhibit an alternatively activated (M2) phenotype have been linked to tumor progression and metastasis. However, the role of M2-polarized macrophages in the growth and metastasis of lung adenocarcinoma remains enigmatic. The aim of this study was to explore the effect of M2 macrophages on the proliferation and migration of mouse Lewis lung carcinoma cells and tumor-induced lymphangiogenesis. METHODS: Trypan blue staining and the Transwell migration assay were performed to evaluate the effects of activated (M1 or M2) macrophages on the proliferation and migration of Lewis cells. Furthermore, vascular endothelial growth factor-C expression in Lewis cells and nitric oxide secretion from activated macrophages were detected during the co-culture assay. Following treatment with activated macrophages, lymphatic endothelial cells differentiated into capillary-like structures, and the induction of Lewis cell migration was assessed using a twodimensional Matrigel-based assay. RESULTS: In the co-culture Transwell system, the proliferation and migration of Lewis cells were promoted by M2 macrophages. Moreover, the co-culture significantly increased the expression of vascular endothelial growth factor-C by Lewis cells and reduced the secretion of nitric oxide from M2 macrophages, which subsequently led to the capillary morphogenesis of lymphatic endothelial cells. Interestingly, following co-culture with Lewis cells, the function of RAW264.7 cells was polarized toward that of the M2 macrophage phenotype. CONCLUSION: M2-polarized macrophages promoted the metastatic behavior of Lewis cells by inducing vascular endothelial growth factor-C expression. Thus, the interruption of signaling between M2 macrophages and Lewis cells may be considered to be a new therapeutic strategy

Emerging Theranostic Nanomaterials in Diabetes and Its Complications

Diabetes mellitus (DM) refers to a group of metabolic disorders that are characterized by hyperglycemia. Oral subcutaneously administered antidiabetic drugs such as insulin, glipalamide, and metformin can temporarily balance blood sugar levels, however, long-term administration of these therapies is associated with undesirable side effects on the kidney and liver. In addition, due to overproduction of reactive oxygen species and hyperglycemia-induced macrovascular system damage, diabetics have an increased risk of complications. Fortunately, recent advances in nanomaterials have provided new opportunities for diabetes therapy and diagnosis. This review provides a panoramic overview of the current nanomaterials for the detection of diabetic biomarkers and diabetes treatment. Apart from diabetic sensing mechanisms and antidiabetic activities, the applications of these bioengineered nanoparticles for preventing several diabetic complications are elucidated. This review provides an overall perspective in this field, including current challenges and future trends, which may be helpful in informing the development of novel nanomaterials with new functions and properties for diabetes diagnosis and therapy.Peer reviewe

Earth observation to investigate occurrence, characteristics and changes of glaciers, glacial lakes and rock glaciers in Poiqu River Basin (Central Himalaya)

This research has been supported by the Dragon 4 program funded by ESA (4000121469/17/I-NB), the Swiss National Science Foundation (grant nos. IZLCZ2_169979/1 and 200021E_177652/1) and the Strategic Priority Research Program of Chinese Academy of Sciences (grant no. XDA20100300).Meltwater from the cryosphere contributes a significant fraction of the freshwater resources in the countries receiving water from the Third Pole. Within the ESA-MOST Dragon 4 project, we addressed in particular changes of glaciers and proglacial lakes and their interaction. In addition, we investigated rock glaciers in permafrost environments. Here, we focus on the detailed investigations which have been performed in the Poiqu River Basin, central Himalaya. We used in particular multi-temporal stereo satellite imagery, including high-resolution 1960/70s Corona and Hexagon spy images and contemporary Pleiades data. Sentinel-2 data was applied to assess the glacier flow. The results reveal that glacier mass loss continuously increased with a mass budget of −0.42 ± 0.11 m w.e.a−1 for the period 2004–2018. The mass loss has been primarily driven by an increase in summer temperature and is further accelerated by proglacial lakes, which have become abundant. The glacial lake area more than doubled between 1964 and 2017. The termini of glaciers that flow into lakes moved on average twice as fast as glaciers terminating on land, indicating that dynamical thinning plays an important role. Rock glaciers are abundant, covering approximately 21 km2, which was more than 10% of the glacier area (approximately 190 km2) in 2015. With ongoing glacier wastage, rock glaciers can become an increasingly important water resource.Publisher PDFPeer reviewe