Effect of EDTA on Copper and Cadmium Absorption in Pharbitis nil and Triticum aestivum

Article信州大学環境科学論集6:94-98(1984)research repor

Sm系及びCe系充填スクッテルダイト化合物の熱電特性

Filled skutterudites have been actively studied as potentially useful thermoelectric materials. SmT4P12 (T=Fe, Ru, Os) and LaxCel-xT4P12(T=Ru, Os) (0 ≤ x ≤ O.2) with the filled skutterudite-type structure have been prepared at high temperature and high pressure. The structure of samples was characterized by powder X-ray diffraction. The thermoelectric properties of these compounds have been investigated by means of electrical resistivity, Seebeck coefficient and thermal conductivity measurements. SmFe4P12 and SmOs4P12 behaved metallic down to 5K, while SmRu4P12 shows metal-insulation transition around 16K. SmFe4P12 showed significantly high values of Seebeck coefficient (46μV/K), comparing to other metallic compounds at the temperature 600K. LaxCel-xT4P12 (T=Ru, Os) (0 ≤ x ≤ 0.2) showed semiconducting behavior, and the power factor was optimized by doping 10% La in CeRu4P12.投稿論

小学校英語教育の未来 : 現状と今後のあるべき姿を考える <シンポジウム>

［問題提起］ 小学校での言語教育を考える―英語教育導入の流れの中で― 大津由紀雄（明海大学外国語学部教授，慶應義塾大学名誉教授） 平成28年1月9日，於　広島大学大学院教育学研究科（広島大学東広島キャンパス

Caenorhabditis elegans HCF-1 Functions in Longevity Maintenance as a DAF-16 Regulator

The transcription factor DAF-16/forkhead box O (FOXO) is a critical longevity determinant in diverse organisms, however the molecular basis of how its transcriptional activity is regulated remains largely unknown. We report that the Caenorhabditis elegans homolog of host cell factor 1 (HCF-1) represents a new longevity modulator and functions as a negative regulator of DAF-16. In C. elegans, hcf-1 inactivation caused a daf-16-dependent lifespan extension of up to 40% and heightened resistance to specific stress stimuli. HCF-1 showed ubiquitous nuclear localization and physically associated with DAF-16. Furthermore, loss of hcf-1 resulted in elevated DAF-16 recruitment to the promoters of its target genes and altered expression of a subset of DAF-16-regulated genes. We propose that HCF-1 modulates C. elegans longevity and stress response by forming a complex with DAF-16 and limiting a fraction of DAF-16 from accessing its target gene promoters, and thereby regulates DAF-16-mediated transcription of selective target genes. As HCF-1 is highly conserved, our findings have important implications for aging and FOXO regulation in mammals

腎細胞癌における腎部分切除術の臨床的検討

著者らの施設において1992年から2001年までに腎細胞癌に対し, 腎部分切除術を施行した54症例(絶対的適応患者11名, 選択的適応患者43名, 観察期間・中央値44ヵ月)の臨床的検討を行った.根治的腎摘除術を施行した症例のうち, 臨床病期Tlaの51症例を比較対象として, 周術期合併症, 手術前後の腎機能, 再発率について調べた結果, 術中の出血量は部分切除群の方が多いものの, 同種血輸血の割合に関して差は認めなかった.両群には, 病理学的所見, 合併症に関して有意差はなかった.また部分切除術後, 2症例に尿瘻, 1症例に腎性高血圧を認めた.部分切除術後の局所再発は認められず, 5年非再発率に関しても両群に有意差を認なかった.術後の腎機能は両群とも安定していたが, 根治的腎摘除後では, 基礎疾患を有する2症例(糖尿病, 腹部動脈瘤術後)において徐々に腎機能低下を示していた.以上より, 小径腎細胞癌に対する腎部分切除術は, 根治的腎摘除術と比較しても, 安全で有用な治療法と示唆されたWe retrospectively reviewed the records of 54 patients with RCC who underwent partial nephrectomy for the primary lesion between 1992 and 2001. The indications for partial nephrectomy were elective in 43 and imperative in 11 patients. We selected 51 patients with clinical stage T1a who underwent open radical nephrectomy for localized RCC for comparison during the same period. We evaluated the peri- and postoperative complications, disease-free survival rates and changes of renal function in the partial nephrectomy (PN) group, compared to the radical nephrectomy (RN) group. There was no significant difference with regard to pathological findings and clinical outcomes between two groups, except for the amount of intraoperative bleeding. Three patients in the PN group developed postoperative complications, consisting of urine leakage in 2 patients and renal hypertension in 1 patient. The 5-year disease-free survival rates in the PN and RN groups were 90% and 97%, respectively. Local recurrence from the resected area of the renal parenchyma was not found in patients in the PN group. All patients in the PN group maintained satisfactory and stable renal function. In the RN group, renal function slowly deteriorated in 2 patients. Therefore, partial nephrectomy offers cancer control and an acceptable low mortality rate, comparable to those of radical nephrectomy