149 research outputs found

    The role of peroxidasin and Bpr1b in eye development and diseases

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    The role of peroxidasin and Bpr1b in eye development and diseases

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    Reliability-based Probabilistic Network Pricing with Demand Uncertainty

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    The future energy system embraces growing flexible demand and generation, which bring large-scale uncertainties and challenges to current deterministic network pricing methods. This paper proposes a novel reliability-based probabilistic network pricing method considering demand uncertainty. Network reliability performance, including probabilistic contingency power flow (PCPF) and tolerance loss of load (TLoL), are used to assess the impact of demand uncertainty on actual network investment cost, where PCPF is formulated by the combined cumulant and series expansion. The tail value at risk (TVaR) is used to generate analytical solutions to determine network reinforcement horizons. Then, final network charges are calculated based on the core of the Long-run incremental cost (LRIC) algorithm. A 15-bus system is employed to demonstrate the proposed method. Results indicate that the pricing signal is sensitive to both demand uncertainty and network reliability, incentivising demand to reduce uncertainties. This is the first-ever network pricing method that determines network investment costs considering both supply reliability and demand uncertainties. It can guide better sitting and sizing of future flexible demand in distribution systems to minimise investment costs and reduce network charges, thus enabling a more efficient system planning and cheaper integration.</p

    Melatonin protects against ovarian damage by inhibiting autophagy in granulosa cells in rats

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    Objectives: This study sought to further verify the protective mechanism of Melatonin (MT) against ovarian damage through animal model experiments and to lay a theoretical and experimental foundation for exploring new approaches for ovarian damage treatment. Method: The wet weight and ovarian index of rat ovaries were weighted, and the morphology of ovarian tissues and the number of follicles in the pathological sections of collected ovarian tissues were recorded. And the serum sex hormone levels, the key proteins of the autophagy pathway (PI3K, AKT, mTOR, LC3II, LC3I, and Agt5) in rat ovarian tissues, as well as the viability and mortality of ovarian granulosa cells in each group were measured by ELISA, western blotting, CCK8 kit and LDH kit, respectively. Results: The results showed that MT increased ovarian weight and improved the ovarian index in ovarian damage rats. Also, MT could improve autophagy-induced ovarian tissue injury, increase the number of primordial follicles, primary follicles, and sinus follicles, and decrease the number of atretic follicles. Furthermore, MT upregulated serum AMH, INH-B, and E2 levels downregulated serum FSH and LH levels in ovarian damage rats and activated the PI3K/AKT/mTOR signaling pathway. Besides, MT inhibited autophagic apoptosis of ovarian granulosa cells and repressed the expression of key proteins in the autophagic pathway and reduced the expression levels of Agt5 and LC3II/I. Conclusions: MT inhibits granulosa cell autophagy by activating the PI3K/Akt/mTOR signaling pathway, thereby exerting a protective effect against ovarian damage

    Waiting Cost based Long-Run Network Investment Decision-making under Uncertainty

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    Optimal Borehole Energy Storage Charging Strategy in a Low Carbon Space Heat System

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    Domestic heating is the major demand of energy systems, which can bring significant uncertainties to system operation and shrink the security margin. From this aspect, the borehole system, as an interseasonal heating storage, can effectively utilize renewable energy to provide heating to ease the adverse impact from domestic heating. This paper proposes an optimal charging strategy for borehole thermal storage by harvesting energy from photovoltaic (PV) generation in a low-carbon space heating system. The system optimizes the heat injection generated by air source heat pump in the charging seasons to charge the borehole, which provides high inlet temperature for ground source heat pump to meet space heating demand in discharging seasons. The borehole is modeled by partial differential equations, solved by the finite-element method at both 2D and 3D for volume simulation. The pattern search optimization is used to resolve the model. The case study illustrates that with the optimal charging strategies, less heat flux injection can help the borehole to reach a higher temperature so that the heating system is more efficient compared with boilers. This paper can benefit communities with seasonable borehole storage to provide clean but low-cost heating and also maximize PV penetration.</p

    Dynamic pricing for responsive demand to increase distribution network efficiency

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    This paper designs a novel dynamic tariff scheme for demand response (DR) by considering networks costs through balancing the trade-off between network investment costs and congestion costs. The objective is to actively engage customers in network planning and operation for reducing network costs and finally their electricity bills. System congestion costs are quantified according to generation and load curtailment by assessing their contribution to network congestion. Plus, network investment cost is quantified through examining the needed investment for resolving system congestion. Customers located at various might face the same energy signals but they are differentiated by network cost signals. Once customers conduct DR during system congested periods, the smaller savings from investment and congestion cost are considered as the economic singles for rewarding the response. The innovation is that the method translates network congestion/investment costs into tariffs, where current research is mainly focused on linking customer response to energy prices. A typical UK distribution network is utilised to illustrate the new approach and results show that derived economic signals can effectively benefit end customers for reducing system congestion costs and deferring required network investment.</p

    Network Pricing with Investment Waiting Cost based on Real Options under Uncertainties

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    A two-stage data-driven multi-energy management considering demand response

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    This paper proposes an innovative two-stage data-driven optimization framework for a multi-energy system. Enormous energy conversion technologies are incorporated in the system to enhance the overall energy utilization efficiency, i.e., combined heat and power, power-to-gas, gas furnace, and ground source heat pump. Furthermore, a demand response program is adopted for stimulating the load shift of customers. Accordingly, both the economic performance and system reliability can be improved. The endogenous solar generation brings about high uncertainty and variability, which affects the decision making of the system operator. Therefore, a two-stage data-driven distributionally robust optimization (TSDRO) method is utilized to capture the uncertainty. A tractable semidefinite programming reformulation is obtained based on the duality theory. Case studies are implemented to demonstrate the effectiveness of applying the TSDRO on energy management.</p
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