Behavioral effects of ketamine and toxic interactions with psychostimulants

BACKGROUND: The anesthetic drug ketamine (KT) has been reported to be an abused drug and fatal cases have been observed in polydrug users. In the present study, considering the possibility of KT-enhanced toxic effects of other drugs, and KT-induced promotion of an overdose without making the subject aware of the danger due to the attenuation of several painful subjective symptoms, the intraperitoneal (i.p.) KT-induced alterations in behaviors and toxic interactions with popular co-abused drugs, the psychostimulants cocaine (COC) and methamphetamine (MA), were examined in ICR mice. RESULTS: A single dose of KT caused hyperlocomotion in a low (30 mg/kg, i.p.) dose group, and hypolocomotion followed by hyperlocomotion in a high (100 mg/kg, i.p.) dose group. However, no behavioral alterations derived from enhanced stress-related depression or anxiety were observed in the forced swimming or the elevated plus-maze test. A single non-fatal dose of COC (30 mg/kg, i.p.) or MA (4 mg/kg, i.p.) caused hyperlocomotion, stress-related depression in swimming behaviors in the forced swimming test, and anxiety-related behavioral changes (preference for closed arms) in the elevated plus-maze test. For the COC (30 mg/kg) or MA (4 mg/kg) groups of mice simultaneously co-treated with KT, the psychostimulant-induced hyperlocomotion was suppressed by the high dose KT, and the psychostimulant-induced behavioral alterations in the above tests were reversed by both low and high doses of KT. For the toxic dose COC (70 mg/kg, i.p.)- or MA (15 mg/kg, i.p.)-only group, mortality and severe seizures were observed in some animals. In the toxic dose psychostimulant-KT groups, KT attenuated the severity of seizures dose-dependently. Nevertheless, the mortality rate was significantly increased by co-treatment with the high dose KT. CONCLUSION: Our results demonstrated that, in spite of the absence of stress-related depressive and anxiety-related behavioral alterations following a single dose of KT treatment, and in spite of the KT-induced anticonvulsant effects and attenuation of stress- and anxiety-related behaviors caused by COC or MA, the lethal effects of these psychostimulants were increased by KT

Toxic cocaine- and convulsant-induced modification of forced swimming behaviors and their interaction with ethanol: comparison with immobilization stress

BACKGROUND: Swimming behaviors in the forced swimming test have been reported to be depressed by stressors. Since toxic convulsion-inducing drugs related to dopamine [cocaine (COC)], benzodiazepine [methyl 6,7-dimethoxy-4-ethyl-β-carboline-carboxylate (DMCM)], γ-aminobutyric acid (GABA) [bicuculline (BIC)], and glutamate [N-methyl-D-aspartate (NMDA)] receptors can function as stressors, the present study compared their effects on the forced swimming behaviors with the effects of immobilization stress (IM) in rats. Their interactions with ethanol (EtOH), the most frequently coabused drug with COC which also induces convulsions as withdrawal symptoms but interferes with the convulsions caused by other drugs, were also investigated. RESULTS: Similar to the IM (10 min) group, depressed swimming behaviors (attenuated time until immobility and activity counts) were observed in the BIC (5 mg/kg IP) and DMCM (10 mg/kg IP) groups at the 5 h time point, after which no toxic behavioral symptoms were observed. However, they were normalized to the control levels at the 12 h point, with or without EtOH (1.5 g/kg IP). In the COC (60 mg/kg IP) and NMDA (200 mg/kg IP) groups, the depression occurred late (12 h point), and was normalized by the EtOH cotreatment. At the 5 h point, the COC treatment enhanced the swimming behaviors above the control level. CONCLUSIONS: Although the physiological stress (IM), BIC, and DMCM also depressed the swimming behaviors, a delayed occurrence and EtOH-induced recovery of depressed swimming were observed only in the COC and NMDA groups. This might be correlated with the previously-reported delayed responses of DA and NMDA neurons rather than direct effects of the drugs, which could be suppressed by EtOH. Furthermore, the characteristic psychostimulant effects of COC seemed to be correlated with an early enhancement of swimming behaviors

Application of Aligned Carbon Nanotube-Reinforced Polymer Composite to Electrothermal Actuator

Electrothermal bimorph actuators have been widely researched, comprising two layers with asymmetric expansion that generate a bending displacement. Actuation performance greatly relies upon the difference of the coefficients of thermal expansion (CTE) between the two material layers. Since traditionally used bimorph materials have positive CTE values, the generated displacements are restricted because of their relatively low CTE difference. Currently, the synthesis and characterization of carbon nanotube (CNT)/polymer composite actuators are topics of intense research activity. CNTs have been attracting much interest because of their superior electrical, thermal and mechanical properties. In addition, the negative CTE value of CNTs in the axial direction has been investigated analytically, leading one to expect that the CTE of the composites in a direction parallel to the CNT alignment will drastically decrease by containing the aligned CNTs into polymer materials. In this chapter, an experimental method for determining the CTE of a CNT in the axial direction is discussed. Based on this result, we demonstrate an electrothermal bimorph actuator having a large bending displacement and high force output using an aligned CNT-reinforced epoxy composite and thin aluminum foil. Performance characteristics including power and work output per unit volume versus frequency are also reviewed

Mechanical and Fracture Properties of Carbon Nanotubes

Carbon nanotubes (CNTs) have attracted much interest because of their superior electrical, thermal, and mechanical properties. These unique properties of CNTs have come to the attention of many scientists and engineers worldwide, eager to incorporate these novel materials into composites and electronic devices. However, before the utilization of these materials becomes mainstream, it is necessary to develop protocols for tailoring the material properties, so that composites and devices can be engineered to given specifications. In this chapter, we review our recent studies, in which we investigate the nominal tensile strength and strength distribution of multi-walled CNTs (MWCNTs) synthesized by the catalytic chemical vapor deposition (CVD) method, followed by a series of high-temperature annealing steps that culminate with annealing at 2900°C. The structural-mechanical relationships of such MWCNTs are investigated through tensile-loading experiments with individual MWCNTs, Weibull-Poisson statistics, transmission electron microscope (TEM) observation, and Raman spectroscopy analysis

Internal noise determines external stochastic resonance in visual perception

AbstractWe provide the first experimental evidence that the internal noise level determines whether external noise can enhance the detectability of a weak signal. We conduct a visual detection experiment in the absence and presence of visual noise. We define three indices of external stochastic resonance effects, consider the spread of the psychometric function without external noise as an internal noise level index, and find that the indices of external stochastic resonance effects negatively correlate with the internal noise level index. Our results suggest that external stochastic resonance depends not only on the external but also on the internal noise level

Cheat detection for MMORPG on P2P environments

NetGames'06 : 5th ACM SIGCOMM workshop on Network and system support for games , Oct 30-31, 2006 , SingaporeIn this paper, we propose a new method for detecting cheat in P2P-based MMORPG. We suppose a typical P2P-based event delivery architecture where the entire game space is divided into subareas and a responsible node (selected from player terminals) delivers each event happened in the sub-area to player nodes there every predetermined time interval called timeslot. In the proposed method, we introduce multiple monitor nodes (selected from player terminals) which monitor the game state and detect cheat when it happens. In order to allow monitor nodes to track the correct game states for the corresponding subarea, we let monitor nodes and a responsible node retain a random number seed and player nodes send their events not only to responsible node but also monitor nodes so that the monitor nodes and the responsible node can uniquely calculate the latest game state from the previous game state and game events which happened during the current timeslot. Either responsible node, monitor nodes or player nodes can detect cheat by comparing hash values of game state which are retained by those nodes periodically, and role back events happened since the last correct game state. Through experiments in PlanetLab, we show that our method achieves practical performance to detect cheats