234 research outputs found
Site-site memory equation approach in study of density/pressure dependence of translational diffusion coefficient and rotational relaxation time of polar molecular solutions: acetonitrile in water, methanol in water, and methanol in acetonitrile
We present results of theoretical study and numerical calculation of the
dynamics of molecular liquids based on combination of the memory equation
formalism and the reference interaction site model - RISM. Memory equations for
the site-site intermediate scattering functions are studied in the
mode-coupling approximation for the first order memory kernels, while
equilibrium properties such as site-site static structure factors are deduced
from RISM. The results include the temperature-density(pressure) dependence of
translational diffusion coefficients D and orientational relaxation times t for
acetonitrile in water, methanol in water and methanol in acetonitrile, all in
the limit of infinite dilution. Calculations are performed over the range of
temperatures and densities employing the SPC/E model for water and optimized
site-site potentials for acetonitrile and methanol. The theory is able to
reproduce qualitatively all main features of temperature and density
dependences of D and t observed in real and computer experiments. In
particular, anomalous behavior, i.e. the increase in mobility with density, is
observed for D and t of methanol in water, while acetonitrile in water and
methanol in acetonitrile do not show deviations from the ordinary behavior. The
variety exhibited by the different solute-solvent systems in the density
dependence of the mobility is interpreted in terms of the two competing origins
of friction, which interplay with each other as density increases: the
collisional and dielectric frictions which, respectively, increase and decrease
with increasing density.Comment: 13 pages, 8 eps-figures, 3 tables, RevTeX4-forma
3-O-Methylfunicone, a Selective Inhibitor of Mammalian Y-Family DNA Polymerases from an Australian Sea Salt Fungal Strain
We isolated a pol inhibitor from the cultured mycelia extract of a fungal strain isolated from natural salt from a sea salt pan in Australia, which was identified as 3-O-methylfunicone by spectroscopic analyses. This compound selectively inhibited the activities of mammalian Y-family DNA polymerases (pols) (i.e., pols η, ι and κ). Among these pols, human pol κ activity was most strongly inhibited, with an IC50 value of 12.5 μM. On the other hand, the compound barely influenced the activities of the other families of mammalian pols, such as A-family (i.e., pol γ), B-family (i.e., pols α, δ and ɛ) or X-family (i.e., pols β, λ and terminal deoxynucleotidyl transferase), and showed no effect on the activities of fish pol δ, plant pols, prokaryotic pols and other DNA metabolic enzymes, such as calf primase of pol α, human immunodeficiency virus type-1 (HIV-1) reverse transcriptase, human telomerase, T7 RNA polymerase, mouse IMP dehydrogenase (type II), human topoisomerases I and II, T4 polynucleotide kinase or bovine deoxyribonuclease I. This compound also suppressed the growth of two cultured human cancer cell lines, HCT116 (colon carcinoma cells) and HeLa (cervix carcinoma cells), and UV-treated HeLa cells exhibited lower clonogenic survival in the presence of inhibitor
Culture and Egocentric Perceptions of Fairness in Conflict and Negotiation
In this article, the authors advanced a cultural view of judgment biases in conflict and negotiation. The authors predicted that disputants’ self-serving biases of fairness would be more prevalent in individualistic cultures, such as the United States, in which the self is served by focusing on one’s positive attributes to “stand out” and be better than others, yet would be attenuated in collectivistic cultures, such as Japan, where the self is served by focusing on one’s negative characteristics to “blend in” (S. J. Heine, D. R. Lehman, H. R. Markus, & S. Kitayama, 1999). Four studies that used different methodologies (free recall, scenarios, and a laboratory experiment) supported this notion. Implications for the science and practice of negotiation are discussed
CRMP5 (Collapsin Response Mediator Protein 5) Regulates Dendritic Development and Synaptic Plasticity in the Cerebellar Purkinje Cells
Collapsin response mediator protein 5 (CRMP5) is one of the CRMP members that expresses abundantly in the developing brain. To examine the in vivo function of CRMP5, we generated crmp5-deficient (crmp5(-/-)) mice. Anti-calbindin immunofluorescence studies of crmp5(-/-) mice revealed aberrant dendrite morphology; specifically, a decrease in the size of soma and diameter of primary dendrite of the cerebellar Purkinje cells at postnatal day 21 (P21) and P28, but not at P14. Coincidentally, CRMP5 is detected in Purkinje cells at P21 and P28 from crmp5(+/-) mice. In cerebellar slices of crmp5(-/-) mice, the induction of long-term depression of excitatory synaptic transmission between parallel fibers and Purkinje cells was deficient. Given that brain-derived neurotrophic factor (BDNF) plays major roles in dendritic development, we tried to elucidate the possible roles of CRMP5 in BDNF signaling. The effect of BDNF to induce dendritic branching was markedly attenuated in cultured crmp5(-/-) neurons. Furthermore, CRMP5 was tyrosine phosphorylated when coexpressed with neurotrophic tyrosine kinase receptor type 2 (TrkB), a receptor for BDNF, in HEK293T cells. These findings suggest that CRMP5 is involved in the development, maintenance and synaptic plasticity of Purkinje cells
Detection of metacercariae of Spelotrema capellae in crabs from Sanyo District, Japan
吸虫Spelotrema capellaeの飼い猫への感染源を調べるために,広島県福山市を中心とした瀬戸内沿岸の河口域に生息するカニにおけるメタセルカリアの感染状況を調査した。調査地のうち広島児内の4ヵ所と岡山県内の1ヵ所のケフサイソガニHemigrapsus PenicillatusからS. capellaeのメタセルカリアが検出された。特に,過去に症例報告のあった猫の行動圏内にある福山市の2ヵ所のケフサイソガニからは高率に検出された。したがってこれらの地方においては飼い猫へのS. capellaeの感染源は河口産のケフサイソガニであることが強く示唆された。The detection of metacercariae of Spelotrema capellae was investigated in crabs that inhabited the river mouth in the Sanyo District, Japan. The metacercaria was detected in crabs from 4 areas of the Hiroshima Prefecture and from 1 area of the Okayama Prefecture. From 2 areas in the Hiroshima Prefecture, the crab, Hemigrapsus penicillatus, showed the high prevalence of metacercariae. This crab could be a source of infection by Spelotrema capellae in domestic cats in these areas
Subaru Hyper Suprime-Cam Survey for An Optical Counterpart of GW170817
We perform a -band survey for an optical counterpart of a binary neutron
star coalescence GW170817 with Subaru/Hyper Suprime-Cam. Our untargeted
transient search covers deg corresponding to the credible
region of GW170817 and reaches the completeness magnitude of mag
on average. As a result, we find 60 candidates of extragalactic transients,
including J-GEM17btc (a.k.a. SSS17a/DLT17ck). While J-GEM17btc is associated
with NGC 4993 that is firmly located inside the 3D skymap of GW170817, the
other 59 candidates do not have distance information in the GLADE v2 catalog or
NASA/IPAC Extragalactic Database (NED). Among 59 candidates, 58 are located at
the center of extended objects in the Pan-STARRS1 catalog, while one candidate
has an offset. We present location, -band apparent magnitude, and time
variability of the candidates and evaluate the probabilities that they are
located inside of the 3D skymap of GW170817. The probability for J-GEM17btc is
being much higher than those for the other 59 candidates
(). Furthermore, the possibility, that at
least one of the other 59 candidates is located within the 3D skymap, is only
. Therefore, we conclude that J-GEM17btc is the most-likely and
distinguished candidate as the optical counterpart of GW170817.Comment: 14 pages, 9 figures. Accepted for publication in PASJ (Publications
of the Astronomical Society of Japan
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