36 research outputs found
Validation of the German version of the Mediterranean Diet Adherence Screener (MEDAS) questionnaire
Diese Dissertation geht um die Validation der deutschen Version des Fragebogen 'Mediterranean Diet Adherence Screener' (MEDAS) im Rahmen der LIBRE (Lebensstilintervention in Frauen mit einer BRCA1 oder BRCA2 Mutation) Studie.:Table of contents
Bibliographical description.......................................................................................iii Background.............................................................................................................. 1
1.1. Lifestyle factors and risk of sporadic breast cancer.......................................... 2
1.2. Mediterranean Diet ........................................................................................... 3
1.3. Non-genetic risk factors for disease in BRCA1 and BRCA2 mutation carriers. 5
1.4. LIBRE trial.......................................................................................................... 6
1.5. Mediterranean Diet Adherence Screener questionnaire.................................... 7
1.5.1. Translation process........................................................................................ 9 1.6. Food Frequency Questionnaire ........................................................................ 9 Aim......................................................................................................................... 10 Publication ............................................................................................................. 11 Summary................................................................................................................ 21 References ............................................................................................................ 25 Abbreviations......................................................................................................... 33 Supplemental Materials ........................................................................................ 35 Statement on own contributions .......................................................................... 46 ErklaĚrung uĚber die eigenstaĚndige Abfassung der Arbeit ...................................... 47 Curriculum Vitae ................................................................................................... 49 Acknowledgements .............................................................................................. 53This dissertation concerns the validation of the German version of the Mediterranean Adherence Screener (MEDAS), in the context of the LIBRE (Lebensstilintervention in Frauen mit einer BRCA1 oder BRCA2) Mutation clinical trial.:Table of contents
Bibliographical description.......................................................................................iii Background.............................................................................................................. 1
1.1. Lifestyle factors and risk of sporadic breast cancer.......................................... 2
1.2. Mediterranean Diet ........................................................................................... 3
1.3. Non-genetic risk factors for disease in BRCA1 and BRCA2 mutation carriers. 5
1.4. LIBRE trial.......................................................................................................... 6
1.5. Mediterranean Diet Adherence Screener questionnaire.................................... 7
1.5.1. Translation process........................................................................................ 9 1.6. Food Frequency Questionnaire ........................................................................ 9 Aim......................................................................................................................... 10 Publication ............................................................................................................. 11 Summary................................................................................................................ 21 References ............................................................................................................ 25 Abbreviations......................................................................................................... 33 Supplemental Materials ........................................................................................ 35 Statement on own contributions .......................................................................... 46 ErklaĚrung uĚber die eigenstaĚndige Abfassung der Arbeit ...................................... 47 Curriculum Vitae ................................................................................................... 49 Acknowledgements .............................................................................................. 5
Potential Co-Factors of an Intraoral Contact AllergyâA Cross-Sectional Study
The aim of this cross-sectional study was to evaluate the frequency of dental allergens and potential co-factors, especially hypothyroidism, for patients with an intraoral contact allergy. From 2015 to 2016, patients with confirmed symptoms of an intraoral contact allergy (study group SG n = 50) were recruited in the dental clinic of the University of Leipzig. The participants of the control group (CG n = 103) were patients without oral diseases or intraoral symptoms of a contact allergy. For the data collection, a new âAllergy questionnaireâ was developed. Information on allergies and general diseases were collected. The statistical analysis was carried out with SPSS 23.0. Sensitizations/allergies to metals and composites were higher in SG compared to CG. Of all study participants (n = 148), 14.2% (n = 21) had a nickel allergy. In 18% (n = 8) of the SG a cobalt allergy based on all metal allergens could be seen. In addition, an association between a nickel and cobalt allergy was found. Hypothyroidism occurred significantly more frequently (p = 0.049) in SG than in CG. Sensitizations and allergies can occur to metals in dental alloys. Hypothyroidism increased the risk of having an allergy threefold
Chest Compression-Related Flail Chest Is Associated with Prolonged Ventilator Weaning in Cardiac Arrest Survivors
Chest compressions during cardiopulmonary resuscitation (CPR) may be associated with iatrogenic chest wall injuries. The extent to which these CPR-associated chest wall injuries contribute to a delay in the respiratory recovery of cardiac arrest survivors has not been sufficiently explored. In a single-center retrospective cohort study, surviving intensive care unit (ICU) patients, who had undergone CPR due to medical reasons between 1 January 2018 and 30 June 2019, were analyzed regarding CPR-associated chest wall injuries, detected by chest radiography and computed tomography. Among 109 included patients, 38 (34.8%) presented with chest wall injuries, including 10 (9.2%) with flail chest. The multivariable logistic regression analysis identified flail chest to be independently associated with the need for tracheostomy (OR 15.5; 95% CI 2.77â86.27; p = 0.002). The linear regression analysis identified pneumonia (β 11.34; 95% CI 6.70â15.99; p < 0.001) and the presence of rib fractures (β 5.97; 95% CI 1.01â10.93; p = 0.019) to be associated with an increase in the length of ICU stay, whereas flail chest (β 10.45; 95% CI 3.57â17.33; p = 0.003) and pneumonia (β 6.12; 95% CI 0.94â11.31; p = 0.021) were associated with a prolonged duration of mechanical ventilation. Four patients with flail chest underwent surgical rib stabilization and were successfully weaned from the ventilator. The results of this study suggest that CPR-associated chest wall injuries, flail chest in particular, may impair the respiratory recovery of cardiac arrest survivors in the ICU. A multidisciplinary assessment may help to identify patients who could benefit from a surgical treatment approach
Validation of the German version of the Mediterranean Diet Adherence Screener (MEDAS) questionnaire
Background: Health benefits of the Mediterranean Diet (MD) have been shown in different at-risk populations. A German translation of the Mediterranean Diet Adherence Screener (MEDAS) from the PREvencion con DIeta MEDiterranea (PREDIMED) consortium was used in the LIBRE study, investigating effects of lifestyle-intervention on women with BRCA1/2 mutations. The purpose of the present study is to validate the MEDAS German version. Methods: LIBRE is a multicentre (three university hospitals during this pilot phase), unblinded, randomized, controlled clinical trial. Women with a BRCA1/2 mutation of age 18 or over who provided written consent were eligible for the trial. As part of the assessment, all were given a full-length Food Frequency Questionnaire (FFQ) and MEDAS at baseline and after 3 months. Data derived from FFQ was compared to MEDAS in order to evaluate agreement or concordance between the two questionnaires. Additionally, the association of dietary intake biomarkers in the blood (beta-carotene, omega-3, omega-6 and omega-9 fatty acids and high-sensitivity C-reactive protein (hsCRP)) with some MEDAS items was analyzed using t-Tests and a multivariate regression. Results: The participants of the LIBRE pilot study were 68 in total (33 Intervention, 35 Control). Only participants who completed both questionnaires were included in this analysis (baseline: 66, month three: 54). The concordance between these two questionnaires varied between the items (Intraclass correlation coefficient of 0.91 for pulses at the highest and -0.33 for sugar-sweetened drinks). Mean MEDAS scores (sum of all items) were 9% higher than their FFQ counter-parts at baseline and 15% after 3 months. Higher fish consumption (at least 3 portions) was associated with lower omega-6 fatty acid levels (p = 0.026) and higher omega-3 fatty acid levels (p = 0.037), both results being statistically significant. Conclusions: We conclude that the German MEDAS in its current version could be a useful tool in clinical trials and in practice to assess adherence to MD
Effects of lifestyle intervention in BRCA1/2 mutation carriers on nutrition, BMI, and physical fitness (LIBRE study): study protocol for a randomized controlled trial
Validation of the German version of the Mediterranean Diet Adherence Screener (MEDAS) questionnaire
Diese Dissertation geht um die Validation der deutschen Version des Fragebogen 'Mediterranean Diet Adherence Screener' (MEDAS) im Rahmen der LIBRE (Lebensstilintervention in Frauen mit einer BRCA1 oder BRCA2 Mutation) Studie.:Table of contents
Bibliographical description.......................................................................................iii Background.............................................................................................................. 1
1.1. Lifestyle factors and risk of sporadic breast cancer.......................................... 2
1.2. Mediterranean Diet ........................................................................................... 3
1.3. Non-genetic risk factors for disease in BRCA1 and BRCA2 mutation carriers. 5
1.4. LIBRE trial.......................................................................................................... 6
1.5. Mediterranean Diet Adherence Screener questionnaire.................................... 7
1.5.1. Translation process........................................................................................ 9 1.6. Food Frequency Questionnaire ........................................................................ 9 Aim......................................................................................................................... 10 Publication ............................................................................................................. 11 Summary................................................................................................................ 21 References ............................................................................................................ 25 Abbreviations......................................................................................................... 33 Supplemental Materials ........................................................................................ 35 Statement on own contributions .......................................................................... 46 ErklaĚrung uĚber die eigenstaĚndige Abfassung der Arbeit ...................................... 47 Curriculum Vitae ................................................................................................... 49 Acknowledgements .............................................................................................. 53This dissertation concerns the validation of the German version of the Mediterranean Adherence Screener (MEDAS), in the context of the LIBRE (Lebensstilintervention in Frauen mit einer BRCA1 oder BRCA2) Mutation clinical trial.:Table of contents
Bibliographical description.......................................................................................iii Background.............................................................................................................. 1
1.1. Lifestyle factors and risk of sporadic breast cancer.......................................... 2
1.2. Mediterranean Diet ........................................................................................... 3
1.3. Non-genetic risk factors for disease in BRCA1 and BRCA2 mutation carriers. 5
1.4. LIBRE trial.......................................................................................................... 6
1.5. Mediterranean Diet Adherence Screener questionnaire.................................... 7
1.5.1. Translation process........................................................................................ 9 1.6. Food Frequency Questionnaire ........................................................................ 9 Aim......................................................................................................................... 10 Publication ............................................................................................................. 11 Summary................................................................................................................ 21 References ............................................................................................................ 25 Abbreviations......................................................................................................... 33 Supplemental Materials ........................................................................................ 35 Statement on own contributions .......................................................................... 46 ErklaĚrung uĚber die eigenstaĚndige Abfassung der Arbeit ...................................... 47 Curriculum Vitae ................................................................................................... 49 Acknowledgements .............................................................................................. 5
Validation of the German version of the Mediterranean Diet Adherence Screener (MEDAS) questionnaire
Diese Dissertation geht um die Validation der deutschen Version des Fragebogen 'Mediterranean Diet Adherence Screener' (MEDAS) im Rahmen der LIBRE (Lebensstilintervention in Frauen mit einer BRCA1 oder BRCA2 Mutation) Studie.:Table of contents
Bibliographical description.......................................................................................iii Background.............................................................................................................. 1
1.1. Lifestyle factors and risk of sporadic breast cancer.......................................... 2
1.2. Mediterranean Diet ........................................................................................... 3
1.3. Non-genetic risk factors for disease in BRCA1 and BRCA2 mutation carriers. 5
1.4. LIBRE trial.......................................................................................................... 6
1.5. Mediterranean Diet Adherence Screener questionnaire.................................... 7
1.5.1. Translation process........................................................................................ 9 1.6. Food Frequency Questionnaire ........................................................................ 9 Aim......................................................................................................................... 10 Publication ............................................................................................................. 11 Summary................................................................................................................ 21 References ............................................................................................................ 25 Abbreviations......................................................................................................... 33 Supplemental Materials ........................................................................................ 35 Statement on own contributions .......................................................................... 46 ErklaĚrung uĚber die eigenstaĚndige Abfassung der Arbeit ...................................... 47 Curriculum Vitae ................................................................................................... 49 Acknowledgements .............................................................................................. 53This dissertation concerns the validation of the German version of the Mediterranean Adherence Screener (MEDAS), in the context of the LIBRE (Lebensstilintervention in Frauen mit einer BRCA1 oder BRCA2) Mutation clinical trial.:Table of contents
Bibliographical description.......................................................................................iii Background.............................................................................................................. 1
1.1. Lifestyle factors and risk of sporadic breast cancer.......................................... 2
1.2. Mediterranean Diet ........................................................................................... 3
1.3. Non-genetic risk factors for disease in BRCA1 and BRCA2 mutation carriers. 5
1.4. LIBRE trial.......................................................................................................... 6
1.5. Mediterranean Diet Adherence Screener questionnaire.................................... 7
1.5.1. Translation process........................................................................................ 9 1.6. Food Frequency Questionnaire ........................................................................ 9 Aim......................................................................................................................... 10 Publication ............................................................................................................. 11 Summary................................................................................................................ 21 References ............................................................................................................ 25 Abbreviations......................................................................................................... 33 Supplemental Materials ........................................................................................ 35 Statement on own contributions .......................................................................... 46 ErklaĚrung uĚber die eigenstaĚndige Abfassung der Arbeit ...................................... 47 Curriculum Vitae ................................................................................................... 49 Acknowledgements .............................................................................................. 5
Potential Co-Factors of an Intraoral Contact AllergyâA Cross-Sectional Study
The aim of this cross-sectional study was to evaluate the frequency of dental allergens and potential co-factors, especially hypothyroidism, for patients with an intraoral contact allergy. From 2015 to 2016, patients with confirmed symptoms of an intraoral contact allergy (study group SG n = 50) were recruited in the dental clinic of the University of Leipzig. The participants of the control group (CG n = 103) were patients without oral diseases or intraoral symptoms of a contact allergy. For the data collection, a new âAllergy questionnaireâ was developed. Information on allergies and general diseases were collected. The statistical analysis was carried out with SPSS 23.0. Sensitizations/allergies to metals and composites were higher in SG compared to CG. Of all study participants (n = 148), 14.2% (n = 21) had a nickel allergy. In 18% (n = 8) of the SG a cobalt allergy based on all metal allergens could be seen. In addition, an association between a nickel and cobalt allergy was found. Hypothyroidism occurred significantly more frequently (p = 0.049) in SG than in CG. Sensitizations and allergies can occur to metals in dental alloys. Hypothyroidism increased the risk of having an allergy threefold
Potential Co-Factors of an Intraoral Contact AllergyâA Cross-Sectional Study
The aim of this cross-sectional study was to evaluate the frequency of dental allergens and potential co-factors, especially hypothyroidism, for patients with an intraoral contact allergy. From 2015 to 2016, patients with confirmed symptoms of an intraoral contact allergy (study group SG n = 50) were recruited in the dental clinic of the University of Leipzig. The participants of the control group (CG n = 103) were patients without oral diseases or intraoral symptoms of a contact allergy. For the data collection, a new âAllergy questionnaireâ was developed. Information on allergies and general diseases were collected. The statistical analysis was carried out with SPSS 23.0. Sensitizations/allergies to metals and composites were higher in SG compared to CG. Of all study participants (n = 148), 14.2% (n = 21) had a nickel allergy. In 18% (n = 8) of the SG a cobalt allergy based on all metal allergens could be seen. In addition, an association between a nickel and cobalt allergy was found. Hypothyroidism occurred significantly more frequently (p = 0.049) in SG than in CG. Sensitizations and allergies can occur to metals in dental alloys. Hypothyroidism increased the risk of having an allergy threefold
Contact allergies to dental materials
There is a lack of epidemiological data on allergies to dental materials. For example, in the recently published fifth German Oral Health Study (DMS V), no information was given on any common allergies or allergies to dental materials. The aim of the present observational study was therefore to determine the frequencies and symptoms of allergies to dental materials. A public consultation hour for allergies of the oral mucosa and material incompatibilities has been integrated in the Department of Dental Prosthodontics and Materials Science in Leipzig, where clinical patient data have systematically been collected since 2012. The objective mucosal findings and the patientsâ complaints are documented in detail in a specifically designed data sheet. This study included 86 subjects (83.7% women and 16.3% men) with oral symptoms of a contact allergy. The average age was 63 years (24â86). The most common allergies were to metals, of which nickel and cobalt were the most common allergens. Furthermore, many allergies were indicated to ingredients of cosmetics and composites. Allergies to components in methacrylate-containing denture resins came in at rank 5. 52.4% of the patients showed mucosal changes. Contact stomatitis (54.5%) and an oral lichenoid lesion (20.5%) were most frequently diagnosed. 86% of the patients reported subjective complaints. Pain and burning sensations in the mouth were mostly reported. Appropriate dental allergy history, clinical examination of the oral cavity for changes in the oral mucosa, analysis of specific dentures, and screening for psychogenic disorders are necessary to clarify the origin of these symptoms