Incomplete Resolution of Deep Vein Thromboses during Rivaroxaban Therapy.

We present the case of a patient with a deep vein thrombosis (DVT) who failed rivaroxaban therapy. Our patient initially presented with left lower extremity edema, erythema, and pain. He was subsequently started on rivaroxaban therapy for a combined treatment period of 12 months, during and after which he persisted to have evidence of a DVT. The patient's prescribed drug regimen was changed from rivaroxaban to warfarin, which demonstrated a rapid resolution of the DVTs as determined by ultrasound assessment of our patient's lower extremity veins. Rivaroxaban, a factor Xa inhibitor, is a well-known oral anticoagulant that is used for a variety of indications and has become a mainstay in the treatment of deep vein thrombosis. With the introduction and emergence of this medication in the clinic, postmarketing reports of efficacy or lack thereof are important to review. In conclusion, we anticipate that it is likely that there are other patients with DVTs who may not respond to rivaroxaban and for whom alternative anticoagulation therapies should be explored

FLC- Implementing High Impact Practices to address DFWI rates - History 140

History 140 syllabus for Fall 2019 addressing DFWI issues

A MULTI-SENSOR PROXIMITY MEASUREMENT SYSTEM ON FPGA FOR AVIONIC APPLICATIONS

Inductive proximity sensors are widely used in the aerospace industry for non-contact metal sensing. The main advantages are that they can operate in a harsh environment, providing a rapid response time and a long operational life. To overcome the problem of temperature drift, this thesis presents a novel excitation method that automatically compensates the temperature variations as well as providing precise distance outputs. The inductance and resistance values of the sensor are measured separately. These values can be used to determine the proximity distance and the temperature of the sensor independently. By having this methodology, a Field-Programmable Gate Array (FPGA) design is implemented using look-up tables and DSP (Digital Signal Processing) blocks to accurately measure the proximity distance based on the measured inductance value. Our experimental data shows that we are able to measure the distance in the range of 0 – 5 mm with less than 2% error in the temperature range of -30 °C and +70 °C. Moreover, this method is scaled to support multiple sensors with different internal characteristics up to 10 sensors using a single processing circuit. This is a major improvement over existing electronic circuits which are limited to one sensor type. Finally, an automated test platform is designed to accelerate the test and development process

Electrochemical detection of carbidopa using a ferrocene-modified carbon nanotube paste electrode

A chemically modified carbon paste electrode (MCPE) containing ferrocene (FC) and carbon nanotubes (CNT) was constructed. The electrochemical behavior and stability of the MCPE were investigated by cyclic voltammetry. The electrocatalytic activity of the MCPE was investigated and it showed good characteristics for the oxidation of carbidopa (CD) in phosphate buffer solution (PBS). A linear concentration range of 5 to 600 μM CD, with a detection limit of 3.6±0.17 μM CD, was obtained. The diffusion coefficient of CD and the transfer coefficient () were also determined. The MCPE showed good reproducibility, remarkable long-term stability and especially good surface renewability by simple mechanical polishing. The results showed that this electrode could be used as an electrochemical sensor for the determination of CD in real samples, such as urine samples

Response of Wheat (Triticum aestivum L.) to Spent Mushroom Compost under Different Moisture Conditions

The effect of spent mushroom compost (SMC) on yield and yield components of wheat (cv. Azar2) under different moisture conditions was evaluated in pot experiment at Dry-land Agricultural Research Institute in 2010. Experiment arrangement was factorial based on complete randomized design with four replications. Treatments were SMC at three levels (0, 25 and 50 Mg.ha-1) and water deficit stress at three levels (-0.3 or field capacity, -5 and -10 bar). Some morphological, yield and yield components of wheat were determined. Results indicated that water stress had a negative and significant (

Diagnostic and Therapeutic Challenges in Managing Persistent Air Leaks

Persistent air leak (PAL) is a common and challenging condition associated with increased morbidity and mortality, intensive care unit admission, and prolonged hospital stay. Multiple medical and surgical approaches have been developed to manage PAL. Depending on the etiology of PAL, surgical management may be effective and usually performed using video-assisted thoracoscopic surgery (VATS). Medical management is less invasive and consists of pleural or bronchoscopic methods. The non-surgical techniques for the management of PAL have not been investigated in large prospective studies, and so their use is mostly guided by observational data. Specifically, the role of intrabronchial valve (IBV) placement for PAL has been the subject of an ever-increasing number of case reports and series documenting successful deployment of IBVs for both surgical and medical PAL. In this case-based discussion, we describe three patients with non-surgical PAL who were managed using multiple modalities, including both surgical and medical approaches. These cases illustrate the challenges in identifying the location of the air leak and in the application of various therapeutic options

Evaluation of the Prevalence of Congenital Heart Diseases in neonates of Ilam province of Iran, in 2019-2020

Background: Congenital heart diseases (CHDs) can cause death and severe disorders in the developmental process of children and, in most cases, are associated with other congenital defects. The current study investigates the prevalence of such defects among infants born in 2019 and 2020.Materials and Methods: This analytical cross-sectional study was conducted in Ilam province on 91 referred neonates, with the possibility of heart diseases, who were diagnosed with CHDs. Demographic, clinical, and definitive diagnoses of cardiologists were recorded and analyzed in these infants, followed by a 6-month follow-up. Data were analyzed using SPSS software with descriptive statistics, Chi-square test, and correlation coefficients.Results: A total of 91 infants out of 16,064 newborns were diagnosed with CHDs, and the prevalence of heart diseases was 5.9 in every 1000 live births. The most frequent defects were ventricular septal defects (VSDs) and PDA, with prevalence rates of 59.3% and 14.2%, respectively. Among 54 VSDs, mus VSD (n = 39) was the most common form of this disorder.Conclusion: The incidence of CHDs in Ilam province was lower than the global average, which may be attributed to the easier access of several cities to the health centers of the bordering provinces. The highlighted results of this study were the frequency of VSDs and the high rates of muscular VSD compared to membranous VSD

Improving oil and flavonoid contents of milk thistle under water stress by salicylic acid

Adverse environmental conditions such as water deficit can limit production. However, some of these adverse effects may be overcome by application of plant growth regulators including salicylic acid (SA). Thus, a field experiment was conducted in 2015 to evaluate the effects of SA (0 and 1 mM l-1) on yield components, seed yield and oil and flavonoid contents of milk thistle (Silybum marianum L.) under different irrigation treatments (I1, I2, I3 and I4: irrigation after 70, 110, 150 and 190 mm evaporation from class A pan, respectively). The experiment was arranged as split-plot based on randomized complete block (RCB) design in three replicates. Irrigation treatments and SA levels were located in the main and sub plots, respectively. The results indicated that plant biomass, seeds per plant, 1000 seed weight, seed yield per unit area and harvest index of milk thistle decreased as a consequence of water stress. Oil percentage and yield were also reduced, but flavonoid content enhanced with increasing water deficit. All these traits were considerably augmented by foliar application of SA under non-stress and stressful conditions. Therefore, it was conclude that SA can be used to improve field performance of milk thistle under different environmental conditions

Radiation-Induced Bystander Signaling Pathways in Human Fibroblasts: A Role for Interleukin-33 in the Signal Transmission

The main goal of this study is to elucidate the mechanisms of the signal transmission for radiation-induced bystander response. The NF-κB-dependent gene expression of IL8, IL6, PTGS2/COX2, TNF and IL33 in directly irradiated human skin fibroblasts produced the cytokines and prostaglandin E2 (PGE2) with autocrine/paracrine functions, which further activated signaling pathways and induced NF-κB-dependent gene expression in bystander cells. As a result, bystander cells also started expression and production of interleukin-8, interleukin-6, COX-2-generated PGE2 and interleukin-33 (IL-33) followed by autocrine/paracrine stimulation of the NF-κB and MAPK pathways. A blockage of IL-33 transmitting functions with anti-IL-33 monoclonal antibody added into the culture media decreased NF-κB activation in directly irradiated and bystander cells. On the other hand, the IGF-1-Receptor kinase regulated the PI3K–AKT pathway in both directly irradiated and bystander fibroblasts. A pronounced and prolonged increase in AKT activity after irradiation was a characteristic feature of bystander cells. AKT positively regulated IL-33 protein expression levels. Suppression of the IGF-R1–AKT–IL-33 pathway substantially increased radiation-induced or TRAIL-induced apoptosis in fibroblasts. Taken together, our results demonstrated the early activation of NF-κB-dependent gene expression first in directly irradiated and then bystander fibroblasts, the further modulation of critical proteins, including IL-33, by AKT in bystander cells and late drastic changes in cell survival and in enhanced sensitivity to TRAIL-induced apoptosis after suppression of the IGF-1R–AKT–IL-33 signaling cascade in both directly irradiated and bystander cells