Determinants of anaemia among adolescent girls in rural Varanasi, Uttar Pradesh

Background: India is home to 253 million adolescents 10-19 years of age, among the largest cohorts globally. This age group comprises of individuals in a transient phase of life requiring nutrition, education, counselling and guidance to ensure their development into healthy adults. Adolescent girls are the most vulnerable group of population due to different reasons especially anaemia. Anaemia is a major public health problem worldwide. The aim of this study was to assess the prevalence of anaemia and associated factors among adolescent girls (10-19 years) in rural Varanasi, Uttar Pradesh. Methods: The present study was a community-based cross-sectional study conducted among 369 adolescent girls in rural Varanasi with a semi-structured and pretested questionnaire. Results: Study shows that the overall prevalence of anaemia among adolescent girls was 67.8% out of which 41.5% and 24.4% were mild and moderately anaemic respectively. Anaemia was significantly associated with age groups, birth order, menarche status, no. of days of menstruation, gap between two cycles, use of clothes/sanitary pads and no. of pads used during menstrual cycle. Conclusions: Study found some preliminary factors significantly associated with anaemia like low socio-economic status, higher birth order, and knowledge about menstrual hygiene practices. Anaemia continues to be a major public health problem in India despite multiple initiatives to address it among adolescent girls

Computational Approach to Generalized Ratio Type Estimator of Population Mean Under Two Phase Sampling

In the present draft, we propose the computational approach to generalized ratio type estimator of population mean of the main variable under study using auxiliary information. The expressions for the bias and mean square errors (MSE) have been obtained up to the first order of approximation. The minimum value of the MSE of the proposed estimator is also obtained for the optimum value of the characterizing scalar. A comparison has been made with the existing estimators of population mean in two phase sampling. A computing based on numerical example also carried out which shows improvement of proposed estimator over other estimators in two phase sampling as the proposed estimator has lesser mean squared error

Exploring the Relational Impact of Service Quality on Customer Satisfication

Customer Satisfaction has been a psychological attribute inviting attention of the customers and requiring decipher their contribution in overall business performance.Banking has been no exception to this phenomenon.Many Literatures have found a strong relationship between service quality and customer satisfaction In service sector in general and banking industry in particular. The aim of the study is to investigate the relationship between service quality and customer satisfaction. The study assesses the level of customers’ satisfaction and service quality performance of the select banks. Further the study compares the satisfaction and service quality in select public and private sector banks.The study also identifies the area where the banks need to focus. The research design is descriptive as the research is intended to conclude and suggest measures to zero down on the service quality gaps in select public and private sector banks. The result shows a positive relationship between service quality and customer satisfaction. Service quality dimensions (tangibility, reliability, responsiveness, assurance and empathy) show wide service quality gaps. The comparative study of public sector banks and private sector banks show superiority of private sector banks over public sector banks in customer satisfaction and performance of service delivery. &nbsp

Cryptococcal meningitis patients associated with HIV co-infection admitted in tertiary care hospital–A Case Series

Meningitis is a significant infection of the central nervous system that is followed by inflammation of the meninges, resulting in catastrophic neurologic consequences. The inflammation may be caused by infection with viruses, bacteria, fungi, or other microorganisms and less commonly by certain drugs. Meningitis can be life-threatening because of the inflammation’s proximity to the brain and spinal cord; therefore, the condition is classified as a medical emergency. In the present case series, we encompass patient demographics, initial clinical symptoms, physical examinations, laboratory results, cerebrospinal fluid examination findings, treatment side effects, the occurrence of complications, and hospital outcomes. Furthermore, documented were any instances of recurrent cryptococcal meningitis (CM) during follow-up, along with the potential causes of recurrence, the treatment modalities administered, any complications that arose, and the ultimate outcomes. This series reveals CM can manifest alongside HIV co-infection in male patients. Therefore, it is essential to consider the possibility of CM when an immune-compromised patient presents with symptoms such as headaches and other indications of central nervous system involvement. These cases reveal cryptococcosis with HIV-infected patients for rapid and early diagnosis and appropriate treatment of opportunistic infections

A framework to assess the challenges to food safety initiatives in an emerging economy

Emerging economies, e.g. India, China and Brazil etc., face challenges to adopt food safety (FS) practices in their food supply chains. Considering food industry’s operations and processes, this study identifies 25 challenges to the FS initiatives involving the opinions of practitioners from six major Indian food producers and academic experts. The challenges are grouped into five categories, viz. organisational, government and policy, global, knowledge and financial. We identify the best and worst challenges to the FS initiatives along with causality among them using combined Best Worst Method (BWM) and ‘Decision Making Trial and Evaluation Laboratory’ (DEMATEL) approaches. BWM prioritises these challenges, while DEMATEL identifies causal relationship maps for the prioritised challenges. The BWM results demonstrate that the government and policy related challenges are the key challenges followed by the organisational, global, knowledge and financial related challenges. The DEMATEL results exhibit the organisational, government and policy, and global related challenges as the cause group challenges. The knowledge and financial related challenges represent the effect group challenges. Mitigation of these challenges inherently necessitates stakeholders’ involvement in the food supply chains. We identify constructs for food safety initiatives policy in the emerging economies to raise public awareness while encouraging greater collaboration and efficiency in food supply chains to help achieve the second Sustainable Development Goal (SDG) for securing food for everyone. The results of the study offer guidance and deeper insights to supply chain managers about synergy requirements between the government policymakers and key players of the industry in the emerging economies

Secondary metabolite induced tolerance to Fusarium oxysporum f.sp. cubense TR4 in banana cv. Grand Naine through in vitro bio-immunization: a prospective research translation from induction to field tolerance

An innovative tissue culture mediated incorporation of metabolite-based biomolecule (Bio-immune) at in vitro stage itself in banana cv. Grand Naine was developed and validated for the production of Fusarium oxysporum f.sp. cubense TR4 tolerant plantlets. The novel bio-immune formulation developed by us, exhibited a significant antifungal potency against Foc TR4 with a high percent inhibition (100%) at a 2.5% concentration of bio-immune on the 5th, 7th, and 9th DAI. Bio-immune integrated during in vitro shoot proliferation stage in banana cv. Grand Naine recorded significant enhancement in the growth of roots and shoots. Bio-immune (0.5%) fortified media produced 12.67 shoots per clump whereas control registered only 9.67 shoots per clump. Similarly, maximum root numbers (7.67) were observed in bio-immune plants which were significantly higher over control (5.0). The bio-immunized banana transplants recorded a higher survival rate (97.57%) during acclimatization as compared to the control (94.53%). Furthermore, evaluation of the bio-immunized plants in pot experiments revealed that unimmunized plants treated with FocTR4 (TF) exhibited mortality between 60 and 90 days. On the 90th day after planting, a high mean disease severity index (DSI) of 3.45 was observed with unimmunized plantlets while the bio-immunized plants (TFBI) and ICAR-FUSICONT treated plants (TFTR) showed substantially reduced DSI (0.20 and 1.00) compared to FocTR4 treated control (TF). Significant increases in polyphenol oxidase (PPO), peroxidase (POD), β-1,3-glucanase, phenylalanine ammonia-lyase (PAL), chitinase activities, and enhanced phenol contents were recorded in bio-immunized plants compared to unimmunized plants. Field experiments at two different locations in Bihar, India revealed that bunch weight, no. of hands/bunch, and no. of fingers/hand of bio-immune treated plants were significantly higher compared to the control

Tumor reversion: a dream or a reality.

Reversion of tumor to a normal differentiated cell once considered a dream is now at the brink of becoming a reality. Different layers of molecules/events such as microRNAs, transcription factors, alternative RNA splicing, post-transcriptional, post-translational modifications, availability of proteomics, genomics editing tools, and chemical biology approaches gave hope to manipulation of cancer cells reversion to a normal cell phenotype as evidences are subtle but definitive. Regardless of the advancement, there is a long way to go, as customized techniques are required to be fine-tuned with precision to attain more insights into tumor reversion. Tumor regression models using available genome-editing methods, followed by in vitro and in vivo proteomics profiling techniques show early evidence. This review summarizes tumor reversion developments, present issues, and unaddressed challenges that remained in the uncharted territory to modulate cellular machinery for tumor reversion towards therapeutic purposes successfully. Ongoing research reaffirms the potential promises of understanding the mechanism of tumor reversion and required refinement that is warranted in vitro and in vivo models of tumor reversion, and the potential translation of these into cancer therapy. Furthermore, therapeutic compounds were reported to induce phenotypic changes in cancer cells into normal cells, which will contribute in understanding the mechanism of tumor reversion. Altogether, the efforts collectively suggest that tumor reversion will likely reveal a new wave of therapeutic discoveries that will significantly impact clinical practice in cancer therapy