Synthesis of C2-Symmetric Bisphosphines and Their Application in Enantioselective Transition Metal Catalysis

C2-symmetric bisphosphine ligands (with a dioxolane backbone) have been synthesized by using corresponding chiral bromo-substituted hydrobenzoin derivatives in two steps with moderate yields. The last step for desired bisphosphines defined the electronic and steric properties of the chelating atoms by the treatment of aryl or alkyl substituted chlorophosphine compounds in the presence of a base. These synthesized ligands have been evaluated in different catalytic reactions. The first application has been the palladiumcatalyzed enantioselective allylic alkylation which is regarded as a remarkable reaction for forming enantioselective carbon-carbon bond (up to 63 % ee and 98 % chemical yield). The ruthenium-catalyzed enantioselective transfer hydrogenation reaction has been the second application for the evaluating of the catalysts (up to > 99 % conversion with no enantioselectivity). This work is licensed under a Creative Commons Attribution 4.0 International License

1,3-Bis[4-(dimethyl­amino)benz­yl]-4,5,6,7-tetra­hydro-1H-1,3-diazepan-2-ium chloride

The title N-heterocyclic carbene derivative, C23H33N4 +·Cl−, has been synthesized and characterized by elemental analysis, 1H and 13C NMR, IR spectroscopy and a single-crystal X-ray diffraction study. Ions of the title compound are linked by three C—H⋯Cl inter­actions. The seven-membered 1,3-diazepane ring has a form inter­mediate between twist-chair and twist-boat

Long-term prognosis of patients with heart failure: Follow-up results of journey HF-TR study population

Background: Despite advances in therapeutic management of patients with heart failure, there is still an increasing morbidity and mortality all over the world. In this study, we aimed to present the 3-year follow-up outcomes of patients included in the Journey HF-TR study in 2016 that has evaluated the clinical characteristics and management of patients with acute heart failure admitted to the hospital and present a national registry data. Methods: The study was designed retrospectively between November 2016 and December 2019. Patient data included in the previously published Journey HF-TR study were used. Among 1606 patients, 1484 patients were included due to dropout of 122 patients due to inhospital death and due to exclusion of 173 due to incomplete data. The study included 1311 patients. Age, gender, concomitant chronic conditions, precipitating factors, New York Heart Association, and left ventricular ejection fraction factors were adjusted in the Cox regression analysis. Results: During the 3-year follow-up period, the ratio of hospitalization and mortality was 70.5% and 52.1%, respectively. Common causes of mortality were acute decompensation of heart failure and acute coronary syndrome. Angiotensin receptor blockers, beta-blockers, statin, and sacubitril/valsartan were found to reduce mortality. Hospitalization due to acute decompensated heart failure, acute coronary syndrome, lung diseases, oncological diseases, and cerebrovascular diseases was associated with the increased risk of mortality. Implantation of cardiac devices also reduced the mortality. Conclusions: Despite advances in therapeutic management of patients with heart failure, our study demonstrated that the long-term mortality still is high. Much more efforts are needed to improve the inhospital and long-term survival of patients with chronic heart failure

1,3-Bis(2-thienylmeth­yl)-4,5-dihydro­imidazolium trichlorido(η6-p-cymene)ruthenate(II)

The asymmetric unit of the title compound, (C13H15N2S2)[RuCl3(C10H14)], contains a 1,3-(2-thienylmeth­yl)-4,5-dihydro­imidazolium cation and a trichlorido(η 6-p-cymene)ruthenate(II) anion. The thio­phene rings of the cation are disordered by an 180° rotation about the thio­phene–CH2 bonds with occupancies of 0.847 (5)/0.153 (5) and 0.700 (5)/0.300 (5), respectively. The Ru atom exhibits a distorted octa­hedral coordination with the benzene ring of the p-cymene ligand formally occupying three sites and three Cl atoms occupying the other three sites. The short C—N bond lengths in the imidazoline ring indicate partial electron delocalization within the N—C—N fragment. Cation and anions are connected through five inter­molecular C—H⋯Cl hydrogen bonds and one C—H⋯π hydrogen bond, forming a three-dimensional hydrogen-bonded network

1,3-Bis(thio­phen-2-ylmeth­yl)-3,4,5,6-tetra­hydro­pyrimidinium trichlorido(η6-p-cymene)ruthenate(II)

The asymmetric unit of the title compound, (C14H17N2S2)[Ru(C10H14)Cl3], contains a 1,3-bis­(thio­phen-2-ylmeth­yl)-3,4,5,6-tetra­hydro­pyrimidinium cation and a trichlorido(η6-p-cymene)ruthenate(II) anion. The Ru atom exhibits a distorted octa­hedral coordination with the benzene ring of the p-cymene ligand formally occupying three sites and three chloride atoms occupying the other three sites. The N—C bond lengths of the N—C—N unit of the pyrimidinium cation are shorter than the average single C—N bond length of 1.48 Å, thus showing double-bond character, indicating a partial electron delocalization within the N—C—N fragment. The pyrimidine ring has an envelope conformation. Four inter­molecular C—H⋯Cl hydrogen bonds generate a three-dimensional hydrogen-bonded framework

The recreational usage area of Kozan Dam Lake and its surroundings.

TEZ8262Tez (Yüksek Lisans) -- Çukurova Üniversitesi, Adana, 2011.Kaynakça (s. 97-98) var.ix, 134 s. : rnk. res., hrt., çizelge ; 29 cm.This research have been realized for determining the decisions of usage recreational areas of Kozan Dam Lake which is situated 5 km.away from the city of Kozan. In order to access the target of the survey, it has been carried out in three stages as it is seen in the course diagram of the method.(diagram 33) At first stage, natural and cultural usage of areas have been examined by observations which have been performed just at the place and with the studies of inventory. The results of the observations have been operated to the maps and done as plansquare. In this studies, performed as plansquare, it has been used the map strip and the unit area is 1hectometer. At the second stage of the survey,all factors that havee been paraphrased at the first stage have been assessed in terms of the accordance of water and waterside. At the last stage, whole values which have been determined for each plansquare shown as graphical on the map.Bu araştırma, Kozan İlçesi'ne 5 km. uzaklıkta bulunan Kozan Baraj Gölü çevresinin rekreasyon alan kullanım kararlarının belirlenmesi amacıyla gerçekleştirilmiştir. Araştırmanın hedefine ulaşılabilmesi için yöntemin akış şemasında da (Şekil 3.3) izleneceği gibi araştırma üç aşamada yürütülmüştür. Araştırmanın birinci aşamasında, doğal veriler ve kültürel alan kullanımları, envanter çalışmaları ve yerinde yapılan gözlemlerle incelenmiştir. Gözlemler plankare bazında yapılmış ve elde edilen bilgiler haritalara işlenmiştir. Plankare bazında yürütülen çalışmalarda harita gridi kullanılmış ve birim alan 1 ha. olarak alınmıştır. Araştırmanın ikinci aşamasında, birinci aşamada yorumlanan ve haritalanan tüm faktörler su ve su kıyısı rekreasyonuna uygunluğu açısından bir sistem içerisinde değerlendirilmeye alınmıştır. Araştırmanın üçüncü aşamasında ise her plankare için saptanan değerler ışığında harita üzerinde su ve su kıyısına uygun kullanım alanları grafiksel olarak gösterilmiştir

The synthesis and characterization of novel porphyrazines containing 5H-dibenz[b,f]azepine units

The synthesis of novel metal-free (H2Pz) and metalloporphyrazines (MgPz), peripherally substituted with eight 5H-dibenz[b,f]azepine was performed by the cyclotetramerization of 1,5-bis(dibenz[b,f]azepinepropylthio)maleonitrile which was synthesized from 5H-dibenz[b,f]azepine and 1,10-diiodo-5,6-dicyano-4,7-dithia-5-decene. The new compounds were characterized by elemental analysis, 1H NMR, 13C NMR, IR, UV-vis and mass spectral data. © 2007

Synthesis and characterization of new metal-free and metallophthalocyanines containing macrobicyclic moieties

The metal-free 5,10 and metallophthalocyanines 11-13 (M = Ni, Zn, Cu) fused in peripheral positions with diazadithiatetraoxa or diazahexaoxamacrobicycles have been prepared by bicyclotetramerization of the newly synthesized isoindolinediimine derivatives of cryptands 4,9 or dicyano substituted macrobicycles 3,8 in the presence of the corresponding metal salts or a strong organic base. The new compounds have been characterized by elemental analysis, 1H and 13C-NMR, IR, UV-visible and mass spectral data. © 2006 Taylor & Francis

Synthesis and characterisation of new porphyrazinato magnesium containing macrobicyclic moieties

Novel porphyrazinato magnesium (MgPz) containing symmetrically four diaza-tetrathia-macrobicycles on peripheral positions was synthesized by the cyclotetramerisation reaction of 5,8,16,23-tetrathia-1,12-diazabicyclo[9.7. 7Şpentacosane-6-en-6,7-dicarbodinitril (9), which was prepared by sequence reaction of N-tosyl-bis[3-bis(tosyloxypropyl)Ş amine (1) and disodium cis-1,2-dicyano-1,2-ethylenedithiolate (8). Elemental analysis, IR, NMR, MS and UV-vis data confirmed the ability of bulky cryptand moieties to induce steric isolation of Pz core in the solid state. © 2011 Taylor & Francis