Investigating the impact of international general certificate of secondary education scores and gender on the diploma programme scores in mathematics and science

Ankara : The Program of Curriculum and Instruction Bilkent University, 2014.Thesis (Master's) -- Bilkent University, 2014.Includes bibliographical references leaves 48-58.Inspired by their goal for a well-rounded education in a world that has become more globalized, an increasing number of schools in the United States, Europe and other parts of the world have been adapting the philosophy and curricula of international schools. While there have been several studies to support Diploma Program as an established curriculum at the senior high school level, there has been little evidence that would support any particular curriculum at the junior high school level. The purpose of this study was to investigate the relationship between external examination scores of International General Certificate of Secondary Education and those of Diploma Program. A purposive sample was drawn from high school students who attended a private international school in a major metropolitan city in Turkey (N = 250). Data were analyzed with a multiple regression approach. Statistically significant and relatively strong relationships were found between external examination scores, both in mathematics and science.Yağız, BurcuM.S

Clinical characteristics, treatment protocols and relapse rates of patients with vascular Behçet's disease: A single center experience

Bu çalışmada, vasküler Behçet Hastalığı (BH) tanısı ile izlediğimiz hastaların klinik, demografik verilerinin değerlendirilmesi, relaps sıklığı ve kullanılan tedavilerle olan ilişkisinin irdelenmesi amaçlanmıştır. BH tanılı 512 hastanın dosyası geriye dönük incelenerek 68 vasküler tutulumlu Behçet hastası tespit edildi. Demografik özellikler, birinci vasküler olay ve varsa nüksü, tedavi protokolleri kaydedildi. Vasküler tutulum sıklığı %13,28’idi. Hastaların %85’i erkekti. En sık alt ekstremitelerde venöz tutulum görüldü (%77,9). İlk vasküler relaps, hastaların %29,4’inde, ikinci vasküler relaps ise %8,8’inde gelişti. Vasküler tutulumlu Behçet hastalarında vasküler tutulumun tespit edilmesini takiben hastaların %73,5’i sistemik immünsüpresif (İS) tedavi, %45,5’i antikoagülan tedavi almıştı. İS tedavi almayan grupta relaps riski anlamlı olarak yüksek bulundu. (p=0.001) Antikoagülan tedavi alan grupta relaps oranı daha fazla olmakla birlikte istatistiksel olarak anlamlı bir fark saptanmadı (p=0.61). Vasküler tutulum sıklıkla erkeklerde görülmektedir. Tedavide İS'ler ve antikoagülanlar kullanılmaktadır. İmmünsupresif tedavi kullanımı vasküler relaps riskini azaltabilir, ancak antikoagülan tedavinin ek faydası gösterilememiştir. Bu konuda daha fazla sayıda hasta ile yapılacak çok merkezli çalışmalara ihtiyaç vardır.In this study, we aimed to evaluate the clinical and demographic data of the patients followed up with the dia gnosis of Vascular Behçet's Disease (BD), and to examine the frequency of relapse and its relationship with the treatments used. The data of 512 patients diagnosed with BD were reviewed retrospectively, and 68 BD with vascular involvement were detected. Demographic characteristics, first vascular event, and recurrence, if any, and treatment protocols were recorded. The frequency of vascular involvement was 13.28%. 85% of the patients were man. Venous involvement was most common in the lower extremities. (77.9%) The first vascular relapse occurred in 29.4% of the patients, and the second vascular relapse occurred in 8.8%. After the first vascular event, 73.5% of the patients received systemic immunosuppressive therapy and 45.5% received anticoagulant therapy. The risk of relapse was found to be significantly higher in the group that did not receive immunosuppressive therapy. (p=0.001) Although the relapse rate was higher in the group receiving anticoagulant treatment, no statistic ally significant difference was found. (p=0.61) Vascular involvement often occurs in male patients. Immunosuppressive therapies an d anticoagu- lants are used in the treatment. The use of immunosuppressive therapy can reduce the risk of vascular relapse. No additional benefit of anticoagulant therapy was observed. Multicenter studies with larger numbers of patients are needed for a better understanding in this issue

The Changing Roles Of The Contemporary In The Ottoman Period Istanbul

Tez (Doktora) -- İstanbul Teknik Üniversitesi, Sosyal Bilimler Enstitüsü, 2017Çalışmada Geç Osmanlı Dönemi İstanbulu’nda İstanbullu-gündelik eşya etkileşimi ele alınmış, eşyanın fikirsel, görsel ve fiziksel boyutlarıyla dolaşıma girdiği kanallar, İstanbullu ve eşya arasındaki karşılaşmaları mümkün kılan platformlar olarak kavramsallaştırılmıştır. Bu karşılaşmaların ürün-kullanıcı ve üretici-tüketici ikiliklerinin dışında boyutlandırılması amaçlanmış, bu amaç doğrultusunda eşyanın üretim, ticaret, sergileme, tamir ve eğitim nesnesi olarak İstanbullunun tüketici, kullanıcı, üretici, tüccar, ticari temsilci, tamirci, yayıncı, yazar ve gözlemci kimlikleriyle girdiği etkileşimler ve bu etkileşimlerin, siyasi otoritenin kalbi fakat aynı zamanda yeniden örgütlenen bir liman kenti olan İstanbul’un demografik, iktisadi ve kentsel panoramalarıyla olan ilişkisi anlaşılmaya çalışılmıştır. Geç Osmanlı Dönemi İstanbulu, Osmanlı siyasi otoritesinin 18. yüzyılın ikinci yarısından 19. yüzyılın sonlarına uzanan dönem boyunca bürokratik, iktisadi, sınai, eğitsel ve sosyal modernizasyona yönelik attığı adımların 19. yüzyılın geneline yayılan kapitalist dünya ekonomisiyle hizalanma süreciyle kaçınılmaz olarak ilişkilendiği tarihsel sürecin getirdiği tüm çatışma ve uzlaşmaların cisimleştiği bir bağlamdır. Özellikle 19. yüzyılın ikinci yarısında yaşanan dış ticaret patlaması, yabancı sermayenin artan varlığı, bürokratik, finansal ve eğitsel kurumlardaki yeniden örgütlenme sonucu kentin yaşadığı sosyal, iktisadi ve fiziksel dönüşüm, kentte eşyayla ilişkili faaliyette bulunan aktörlerin faaliyetlerindeki ve bu aktörlerin bağlamla ilişkilenme biçimlerindeki değişimi de tetiklemiştir. Tez çalışması kapsamında eşya, üretim, ticaret, sergileme, tamir ve eğitim nesnesi olarak anlık ya da dönemlik dolayımlayıcılığıyla ön plana çıkan ve bu değişimde rol oynayan hayati bir aktör olarak ele alınmıştırPh.D

A rare cause of thrombocytopenia: Cyclic thrombocytopenia

İstanbul Bilim Üniversitesi, Tıp Fakültesi.Siklik trombositopeni (STP), trombosit sayısında periyodik olarak dalgalanma ile seyreden, tipik olarak trombositopeniyi takip eden rebound trombositoz ile karakterize, nadir görülen bir hastalıktır. İmmün trombositopeni (İTP) ve STP benzer özellikler paylaştığından, STP’li hastalara sıklıkla yanlışlıkla İTP tanısı konulabilmektedir. Bu yazıda, daha önce İTP tanısı konulan ve İTP tedavilerine yanıtsız kalınca merkezimize başvuran 45 yaşında bir kadın STP olgusu sunuldu.Cyclic thrombocytopenia (CTP) is a rare disease with periodic fluctuations of platelet counts, which is characterized by a typical thrombocytopenia followed by a rebound thrombocytosis. As immune thrombocytopenia (ITP) and CTP shares similar traits, patients with CTP are often misdiagnosed with ITP. In this paper, we present a 45-year-old female CTP case who was previously diagnosed as ITP and admitted to our center since she had no response to ITP therapies

Vaccination Rates and Influencing Factors in Patients with Axial Spondyloarthritis and Immunosuppressive Treatment—A Survey-Based Cross-Sectional Study

Patients with axial spondyloarthritis (axSpA) who receive immunosuppressive therapy are at risk of infection due to impaired immune function and immunosuppressive medication. Vaccination plays a crucial role in preventing infections in this population. However, vaccination rates and factors influencing vaccination uptake in axSpA patients still need to be adequately studied. This study was designed to determine the vaccination rates of vaccines covered by health insurance in this particular group in Turkey and attitudes towards vaccines and infections. This survey included 199 patients with axSpA who visited our outpatient clinic in June, July, and August 2023 and received biologic and targeted synthetic disease-modifying antirheumatic drugs. The mean age of the participants was 43.7 ± 0.7 years, and the majority were male (66.3%). The majority of the patients were vaccinated against COVID-19 (85.4%), followed by hepatitis B (41.2%), influenza (20.1%), and pneumococcal pneumonia (10.5%). While awareness of COVID-19 vaccination was widespread (100%), knowledge of other vaccines was lower (hepatitis B 80.9%, influenza 70.3%, pneumococcal 60.3%, respectively). Educational interventions targeting patients and healthcare professionals are needed to improve vaccination rates in this population. Our findings emphasize the need for strategies to increase vaccination rates in axSpA patients receiving immunosuppressive therapy. Removing barriers to vaccination and raising awareness of the importance of vaccination are critical to optimizing vaccination practices in this vulnerable population

In the era of disease-modifying antirheumatic drugs, how close are we to treating rheumatoid arthritis without the use of glucocorticoids?

We wanted to see how close we could get to our goal of treating rheumatoid arthritis (RA) without the use of glucocorticoids (GCs) in the disease-modifying antirheumatic drugs (DMARDs) era using real-life data. Established in 2017, the TReasure database is a web-based, prospective, observational cohort for Turkey. As of May 2019, there were 2,690 RA patients recorded as receiving biologic and targeted synthetic DMARDs (bDMARDs and tsDMARDs) therapy. At the start of the bDMARDs or tsDMARDs, patients with follow-up visits of at least 3 months were registered. At the time of registration and the last visit, doses of GCs were recorded and it was determined if the target dose of = 7.5 mg/day was found to be crucial in not reaching the GC target dose (p = 7.5 mg/day, female gender, age, RF positivity, high DAS28, and VAS pain level were all highly related for GC continuation. Despite the use of DMARDs, our data revealed that we are still far from achieving our goal of treating RA without using steroids.Hacettepe Rheumatology Association (HRD); Hacettepe Financial EnterprisesHacettepe Rheumatology Association (HRD) and Hacettepe Financial Enterprises

Pan-Immune-Inflammation Value Could Be a New Marker to Predict Amyloidosis and Disease Severity in Familial Mediterranean Fever

Familial Mediterranean fever (FMF) is characterized by recurrent episodes of fever and serositis. Blood-based biomarkers determined in FMF patients during attack-free periods could be used to predict the risk of amyloidosis and the severity of the disease. The recently defined pan-immune-inflammation value (PIV) comprises four distinct subsets of blood cells and serves as an easily accessible and cost-effective marker. The objective of this study was to assess the role of PIV in predicting amyloidosis and moderate-to-severe disease. Clinical characteristics and laboratory values during the attack-free period were retrospectively analyzed in 321 patients over 18 years of age diagnosed with familial Mediterranean fever (FMF). In our tertiary adult rheumatology outpatient clinic, disease severity and laboratory markers were evaluated during the first attack-free interval. At baseline, patients with amyloidosis were excluded. Patients were categorized based on the presence of amyloidosis and the severity of the disease. When focusing on amyloidosis in receiver operating characteristic (ROC) analysis, optimal cut-off values for pan-immune-inflammation value (PIV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio were determined as ≥518.1, ≥2.3, and ≥127.2, respectively. In multivariate analysis, PIV, C-reactive protein (CRP), and the presence of the M694V homozygous mutation emerged as independent risk factors for both amyloidosis and moderate-to-severe disease. Additionally, NLR was identified as an independent risk factor for amyloidosis, while red blood cell distribution width was associated with moderate-to-severe disease. In patients with FMF, especially in the presence of the M694V homozygous mutation, CRP and PIV may be useful in predicting both amyloidosis and moderate-to-severe disease