Fine-Grained Cryptography Revisited

Fine-grained cryptographic primitives are secure against adversaries with bounded resources and can be computed by honest users with less resources than the adversaries. In this paper, we revisit the results by Degwekar, Vaikuntanathan, and Vasudevan in Crypto 2016 on fine-grained cryptography and show constructions of three key fundamental fine-grained cryptographic primitives: one-way permutations, hash proof systems (which in turn implies a public-key encryption scheme against chosen chiphertext attacks), and trapdoor one-way functions. All of our constructions are computable in $\mathsf{NC}^1$ and secure against (non-uniform) $\mathsf{NC}^1$ circuits under the widely believed worst-case assumption $\mathsf{NC}^1 \subsetneq \oplus \mathsf{L/poly}$

Interethnic analyses of blood pressure loci in populations of East Asian and European descent

Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.</p

Technology-based trainings on emotions: A web application on earthquake-related emotional prevention with children

In light of their potential for learning and engagement, using technology-based programs can be particularly relevant to enhance children\u2019s emotional compe-tence, also in relation to traumatic events such as disasters. Some studies investi-gated the efficacy of technology-based interventions fostering this ability, focus-ing on its different components, with different populations, and using different designs, but they did not relate specifically to disasters such as earthquakes. Nev-ertheless, in everyday life knowledge on earthquakes can be promoted through the use of mobile applications. We searched electronically all the applications pre-sent within the Google Play Store, identifying 20 applications on earthquake pre-vention. None of them was specifically focused on earthquake-related emotional contents, but some of them included some emotional elements. Therefore, to fill in the gaps in the current psychological literature, we developed a web application to promote earthquake-related emotional knowledge, to be tested in the future ac-cording to the standards of evidence-based research

Functional characterization of lysosomal interaction of Akt with VRK2

Serine-threonine kinase Akt (also known as PKB, protein kinase B), a core intracellular mediator of cell survival, is involved in various human cancers and has been suggested to play an important role in the regulation of autophagy in mammalian cells. Nonetheless, the physiological function of Akt in the lysosomes is currently unknown. We have reported previously that PtdIns (3)P-dependent lysosomal accumulation of the Akt-Phafin2 complex is a critical step for autophagy induction. Here, to characterize the molecular function of activated Akt in the lysosomes in the process of autophagy, we searched for the molecules that interact with the Akt complex at the lysosomes after induction of autophagy. By time-of-flight-mass spectrometry (TOF/MS) analysis, kinases of the VRK family, a unique serine-threonine family of kinases in the human kinome, were identified. VRK2 interacts with Akt1 and Akt2, but not with Akt3; the C terminus of Akt and the N terminus of VRK2 facilitate the interaction of Akt and VRK2 in mammalian cells. The kinase-dead form of VRK2A (KD VRK2A) failed to interact with Akt in coimmunoprecipitation assays. Bimolecular fluorescence complementation (BiFC) experiments showed that, in the lysosomes, Akt interacted with VRK2A but not with VRK2B or KD VRK2A. Immunofluorescent assays revealed that VRK2 and phosphorylated Akt accumulated in the lysosomes after autophagy induction. WT VRK2A, but not KD VRK2A or VRK2B, facilitated accumulation of phosphorylated Akt in the lysosomes. Downregulation of VRK2 abrogated the lysosomal accumulation of phosphorylated Akt and impaired nuclear localization of TFEB; these events coincided to inhibition of autophagy induction. The VRK2-Akt complex is required for control of lysosomal size, acidification, bacterial degradation, and for viral replication. Moreover, lysosomal VRK2-Akt controls cellular proliferation and mitochondria) outer-membrane stabilization. Given the roles of autophagy in the pathogenesis of human cancer, the current study provides a novel insight into the oncogenic activity of VRK2-Akt complexes in the lysosomes via modulation of autophagy