A large eddy simulation turbulence model for coastal seas and shallow water problems

2001-2002 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

An experimental investigation on the two-phase flow structure of sand jets

2002-2003 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Double-diffusive Marangoni convection in a rectangular cavity : onset of convection

2009-2010 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

A large eddy simulation turbulence model for estuary using spline correction

2006-2007 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

In-line response of vertical cylinders in regular and random waves

2007-2008 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Three-dimensional double-diffusive Marangoni convection in a cubic cavity with horizontal temperature and concentration gradients

2010-2011 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Onset of double-diffusive convection in a rectangular cavity with stress-free upper boundary

2010-2011 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

New ruthenium complexes of fullerene C-60&C-70

The new complexes [Ru(NO)(PPh3)](2)(eta(2)-C-m)(m=60 1 or 70 2) have been prepared by heating a solution of C-60(or C-70) with [Ru(NO)(2)(PPh3)(2)] in toluene. They have been characterized by elemental analysis, IR, UV/VIS, XPS, C-13 and P-31 NMR spectroscopy. The photovaltaic effect for the new compounds has been studied

Regulatory subunits of PKA define an axis of cellular proliferation/differentiation in ovarian cancer cells

<p>Abstract</p> <p>Background</p> <p>The regulatory subunit of cAMP-dependent protein kinase (PKA) exists in two isoforms, RI and RII, which distinguish the PKA isozymes, type I (PKA-I) and type II (PKA-II). Evidence obtained from a variety of different experimental approaches has shown that the relative levels of type I and type II PKA in cells can play a major role in determining the balance between cell growth and differentiation. In order to characterize the effect of PKA type I and type II regulatory subunits on gene transcription at a global level, the PKA regulatory subunit genes for RIα and RIIβ were stably transfected into cells of the ovarian cancer cell line (OVCAR8).</p> <p>Results</p> <p>RIα transfected cells exhibit hyper-proliferative growth and RIIβ transfected cells revert to a relatively quiescent state. Profiling by microarray revealed equally profound changes in gene expression between RIα, RIIβ, and parental OVCAR cells. Genes specifically up-regulated in RIα cells were highly enriched for pathways involved in cell growth while genes up-regulated in RIIβ cells were enriched for pathways involved in differentiation. A large group of genes (~3600) was regulated along an axis of proliferation/differentiation between RIα, parental, and RIIβ cells. RIα/wt and RIIβ/wt gene regulation was shown by two separate and distinct gene set analytical methods to be strongly cross-correlated with a generic model of cellular differentiation.</p> <p>Conclusion</p> <p>Overexpression of PKA regulatory subunits in an ovarian cancer cell line dramatically influences the cell phenotype. The proliferation phenotype is strongly correlated with recently identified clinical biomarkers predictive of poor prognosis in ovarian cancer suggesting a possible pivotal role for PKA regulation in disease progression.</p

Synthesis and redox study for complex C60Pt (CO) (Pph(3))

Fullerene and it's dervant have unique poperties on physics and chemistry. The main purpose of the synthesis of new type fullerene complexes is to exploit the applications of fullerene and it's dervant as functional materials. The method of ligand substituting was employed, by which, the fullerene complexe C60Pt(CO) (Pph(3)) has been perpared by the reaction of C-60 replacing the ligands CO and Pph(3) in Pt(CO)(2) (Pph(3))(2) under a nitrogen atmosphere and refluxing. The tide compound was characterized by elemental analysis, FT-IR, UV-vis, XPS. The results show that the structure of purposeful product is that the ligands CO and Pph(3) take up two coordination sites of the central metal, and C-60 take up another two sites in sigma-pi feeback pattern. The electron flowing power of the molecule is strong, because of super conjugation in the molecule. The complexe may have super poperties on photo-electricity and catalysis. The result of redox research indicates that the reduction potential of the complexe is more negative than that of pure C-60