XML data integrity based on concatenated hash function

Data integrity is the fundamental for data authentication. A major problem for XML data authentication is that signed XML data can be copied to another document but still keep signature valid. This is caused by XML data integrity protecting. Through investigation, the paper discovered that besides data content integrity, XML data integrity should also protect element location information, and context referential integrity under fine-grained security situation. The aim of this paper is to propose a model for XML data integrity considering XML data features. The paper presents an XML data integrity model named as CSR (content integrity, structure integrity, context referential integrity) based on a concatenated hash function. XML data content integrity is ensured using an iterative hash process, structure integrity is protected by hashing an absolute path string from root node, and context referential integrity is ensured by protecting context-related elements. Presented XML data integrity model can satisfy integrity requirements under situation of fine-grained security, and compatible with XML signature. Through evaluation, the integrity model presented has a higher efficiency on digest value-generation than the Merkle hash tree-based integrity model for XML data

Recent development in XML-IR

The Web is characterized by a huge amount of heterogeneous data sources, which have different media support and format representation. Because XML can represent files of different formats, it can play an important role in IR since it is becoming a standard form for data representation and exchange over the Web. Under this assumption, the problem of querying heterogeneous sources can be reduced to the problem of querying XML data sources. This paper shows the influence of XML on the IR techniques and methodologies during the last five years through serving over 400 papers published in different conferences and journals

Effect of hydroxyurea on the promoter occupancy profiles of tumor suppressor p53 and p73

<p>Abstract</p> <p>Background</p> <p>The p53 tumor suppressor and its related protein, p73, share a homologous DNA binding domain, and mouse genetics studies have suggested that they have overlapping as well as distinct biological functions. Both p53 and p73 are activated by genotoxic stress to regulate an array of cellular responses. Previous studies have suggested that p53 and p73 independently activate the cellular apoptotic program in response to cytotoxic drugs. The goal of this study was to compare the promoter-binding activity of p53 and p73 at steady state and after genotoxic stress induced by hydroxyurea.</p> <p>Results</p> <p>We employed chromatin immunoprecipitation, the NimbleGen promoter arrays and a model-based algorithm for promoter arrays to identify promoter sequences enriched in anti-p53 or anti-p73 immunoprecipitates, either before or after treatment with hydroxyurea, which increased the expression of both p53 and p73 in the human colon cancer cell line HCT116-3(6). We calculated a model-based algorithm for promoter array score for each promoter and found a significant correlation between the promoter occupancy profiles of p53 and p73. We also found that after hydroxyurea treatment, the p53-bound promoters were still bound by p73, but p73 became associated with additional promoters that that did not bind p53. In particular, we showed that hydroxyurea induces the binding of p73 but not p53 to the promoter of <it>MLH3</it>, which encodes a mismatch repair protein, and causes an up-regulation of the <it>MLH3 </it>mRNA.</p> <p>Conclusion</p> <p>These results suggest that hydroxyurea exerts differential effects on the promoter-binding functions of p53 and p73 and illustrate the power of model-based algorithm for promoter array in the analyses of promoter occupancy profiles of highly homologous transcription factors.</p

A Flexible Privacy-preserving Framework for Singular Value Decomposition under Internet of Things Environment

The singular value decomposition (SVD) is a widely used matrix factorization tool which underlies plenty of useful applications, e.g. recommendation system, abnormal detection and data compression. Under the environment of emerging Internet of Things (IoT), there would be an increasing demand for data analysis to better human's lives and create new economic growth points. Moreover, due to the large scope of IoT, most of the data analysis work should be done in the network edge, i.e. handled by fog computing. However, the devices which provide fog computing may not be trustable while the data privacy is often the significant concern of the IoT application users. Thus, when performing SVD for data analysis purpose, the privacy of user data should be preserved. Based on the above reasons, in this paper, we propose a privacy-preserving fog computing framework for SVD computation. The security and performance analysis shows the practicability of the proposed framework. Furthermore, since different applications may utilize the result of SVD operation in different ways, three applications with different objectives are introduced to show how the framework could flexibly achieve the purposes of different applications, which indicates the flexibility of the design.Comment: 24 pages, 4 figure

Influence of human body on massive MIMO indoor channels

© 2019 IEEE. Massive MIMO can dramatically improve capacity and spectral efficiency. However, it is not very clear whether it can significantly improve the signal blockage problem that exists in single antenna systems. In this paper, we investigate the impact of the human body on indoor massive MIMO channels, using practically measured channel data for a 32x8 massive MIMO system in a complex office environment. We introduce a parameter of Power Imbalance (PI) indices to estimate the wide-sense none-stationarity in multiple domains and another parameter of Channel Popularity Indices (CPI) to predict the popularity of MIMO channel. We find that in most cases, the presence of the human body still has a non- negligible negative impact. It decreases the ergodic capacity by about 8% and increases the path loss exponent by 1. In average, the ergodic capacity for NLOS channels are 15% higher than that for LOS

Joint Communication and Radar Sensing in 5G Mobile Network by Compressive Sensing

© 2019 IEEE. There is growing interest in integrating communication and radar sensing into one system. However, very limited results are reported on how to realize sensing using complicated mobile signals when joint communication and radar sensing (JCAS) is applied to mobile networks. This paper studies radar sensing using one-dimension (1D) to 3D compressive sensing (CS) techniques, referring to signals compatible with latest fifth generation (5G) new radio (NR) standard. We demonstrate that radio sensing using both downlink and uplink 5G signals can be realized with reasonable performance using these CS techniques, and highlight the respective advantages and disadvantages of these techniques.

Protection against Staphylococcus aureus colonization and infection by B-and T-cell-mediated mechanisms

© 2018 Zhang et al. Staphylococcus aureus is a major cause of morbidity and mortality worldwide. S. aureus colonizes 20 to 80% of humans at any one time and causes a variety of illnesses. Strains that are resistant to common antibiotics further complicate management. S. aureus vaccine development has been unsuccessful so far, largely due to the incomplete understanding of the mechanisms of protection against this pathogen. Here, we studied the role of different aspects of adaptive immunity induced by an S. aureus vaccine in protection against S. aureus bacteremia, dermonecrosis, skin abscess, and gastrointestinal (GI) colonization. We show that, depending on the challenge model, the contributions of vaccine-induced S. aureus-specific antibody and Th1 and Th17 responses to protection are different: antibodies play a major role in reducing mortality during S. aureus bacteremia, whereas Th1 or Th17 responses are essential for prevention of S. aureus skin abscesses and the clearance of bacteria from the GI tract. Both antibody-and T-cell-mediated mechanisms contribute to prevention of S. aureus dermonecrosis. Engagement of all three immune pathways results in the most robust protection under each pathological condition. Therefore, our results suggest that eliciting multipronged humoral and cellular responses to S. aureus antigens may be critical to achieve effective and comprehensive immune defense against this pathogen. IMPORTANCE S. aureus is a leading cause of healthcare-and community-associated bacterial infections. S. aureus causes various illnesses, including bacteremia, meningitis, endocarditis, pneumonia, osteomyelitis, sepsis, and skin and soft tissue infections. S. aureus colonizes between 20 and 80% of humans; carriers are at increased risk for infection and transmission to others. The spread of multidrug-resistant strains limits antibiotic treatment options. Vaccine development against S. aureus has been unsuccessful to date, likely due to an inadequate understanding about the mechanisms of immune defense against this pathogen. The significance of our work is in illustrating the necessity of generating multipronged B-cell, Th1-, and Th17-mediated responses to S. aureus antigens in conferring enhanced and broad protection against S. aureus invasive infection, skin and soft tissue infection, and mucosal colonization. Our work thus, provides important insights for future vaccine development against this pathogen

Absolute quantitation of DNA methylation of 28 candidate genes in prostate cancer using pyrosequencing

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Aberrant DNA methylation plays a pivotal role in carcinogenesis and its mapping is likely to provide biomarkers for improved diagnostic and risk assessment in prostate cancer (PCa). We quantified and compared absolute methylation levels among 28 candidate genes in 48 PCa and 29 benign prostate hyperplasia (BPH) samples using the pyrosequencing (PSQ) method to identify genes with diagnostic and prognostic potential. RARB, HIN1, BCL2, GSTP1, CCND2, EGFR5, APC, RASSF1A, MDR1, NKX2-5, CDH13, DPYS, PTGS2, EDNRB, MAL, PDLIM4, HLAa, ESR1 and TIG1 were highly methylated in PCa compared to BPH (p < 0.001), while SERPINB5, CDH1, TWIST1, DAPK1, THRB, MCAM, SLIT2, CDKN2a and SFN were not. RARB methylation above 21% completely distinguished PCa from BPH. Separation based on methylation level of SFN, SLIT2 and SERPINB5 distinguished low and high Gleason score cancers, e.g. SFN and SERPINB5 together correctly classified 81% and 77% of high and low Gleason score cancers respectively. Several genes including CDH1 previously reported as methylation markers in PCa were not confirmed in our study. Increasing age was positively associated with gene methylation (p < 0.0001). Accurate quantitative measurement of gene methylation in PCa appears promising and further validation of genes like RARB, HIN1, BCL2, APC and GSTP1 is warranted for diagnostic potential and SFN, SLIT2 and SERPINB5 for prognostic potential

Violet electroluminescence of AlInGaN-InGaN multiquantum-well light-emitting diodes: Quantum-confined stark effect and heating effect

Electroluminescence (EL) from AlInGaN-InGaN multiquantum-well violet light-emitting diodes is investigated as a function of forward bias. Two distinct regimes have been identified: 1) quantum-confined Stark effect at low and moderately high forward biases; 2) heating effect at high biases. In the different regimes, the low-temperature EL spectra exhibit different spectral features which are discussed in detail. © 2007 IEEE.published_or_final_versio

Dual pulse shaping transmission with complementary nyquist pulses

© 2019 IEEE. The concept of complementary Nyquist pulse is introduced in this paper. Making use of a half rate Nyquist pulse and its complementary one, a dual pulse shaping transmission scheme is proposed, which achieves full Nyquist rate transmission with only a half of the sampling rate required by conventional Nyquist pulse shaping. This is essential for realizing high-speed digital communication systems with available and affordable data conversion devices. The condition for cross-symbol interference free transmission with the proposed dual pulse shaping is proved in theory, and two classes of ideal complementary Nyquist pulses are formulated assuming raised-cosine pulse shaping. Simulation results are also presented to demonstrate the improved spectral efficiency with dual pulse shaping and compare other system performance against conventional Nyquist pulse shaping