856 research outputs found
STM and RHEED study of the Si(001)-c(8x8) surface
The Si(001) surface deoxidized by short annealing at T~925C in the ultrahigh
vacuum molecular beam epitaxy chamber has been in situ investigated by high
resolution scanning tunnelling microscopy (STM) and reflected high energy
electron diffraction (RHEED). RHEED patterns corresponding to (2x1) and (4x4)
structures were observed during sample treatment. The (4x4) reconstruction
arose at T<600C after annealing. The reconstruction was observed to be
reversible: the (4x4) structure turned into the (2x1) one at T>600C, the (4x4)
structure appeared again at recurring cooling. The c(8x8) reconstruction was
revealed by STM at room temperature on the same samples. A fraction of the
surface area covered by the c(8x8) structure decreased as the sample cooling
rate was reduced. The (2x1) structure was observed on the surface free of the
c(8x8) one. The c(8x8) structure has been evidenced to manifest itself as the
(4x4) one in the RHEED patterns. A model of the c(8x8) structure formation has
been built on the basis of the STM data. Origin of the high-order structure on
the Si(001) surface and its connection with the epinucleation phenomenon are
discussed.Comment: 26 pages, 12 figure
Foot Bone in Vivo: Its Center of Mass and Centroid of Shape
This paper studies foot bone geometrical shape and its mass distribution and
establishes an assessment method of bone strength. Using spiral CT scanning,
with an accuracy of sub-millimeter, we analyze the data of 384 pieces of foot
bones in vivo and investigate the relationship between the bone's external
shape and internal structure. This analysis is explored on the bases of the
bone's center of mass and its centroid of shape. We observe the phenomenon of
superposition of center of mass and centroid of shape fairly precisely,
indicating a possible appearance of biomechanical organism. We investigate two
aspects of the geometrical shape, (i) distance between compact bone's centroid
of shape and that of the bone and (ii) the mean radius of the same density bone
issue relative to the bone's centroid of shape. These quantities are used to
interpret the influence of different physical exercises imposed on bone
strength, thereby contributing to an alternate assessment technique to bone
strength.Comment: 9 pages, 4 figure
Separation of Oligosaccharides from Lotus Seeds via Medium-pressure Liquid Chromatography Coupled with ELSD and DAD
peer-reviewedLotus seeds were identified by the Ministry of Public Health of China as both food and medicine. One general function of lotus seeds is to improve intestinal health. However, to date, studies evaluating the relationship between bioactive compounds in lotus seeds and the physiological activity of the intestine are limited. In the present study, by using medium pressure liquid chromatography coupled with evaporative light-scattering detector and diode-array detector, five oligosaccharides were isolated and their structures were further characterized by electrospray ionization-mass spectrometry and gas chromatography-mass spectrometry. In vitro testing determined that LOS3-1 and LOS4 elicited relatively good proliferative effects on Lactobacillus delbrueckii subsp. bulgaricus. These results indicated a structure-function relationship between the physiological activity of oligosaccharides in lotus seeds and the number of probiotics applied, thus providing room for improvement of this particular feature. Intestinal probiotics may potentially become a new effective drug target for the regulation of immunity
Natural gaits of the non-pathological flat foot and high-arched foot
There has been a controversy as to whether or not the non-pathological flat
foot and high-arched foot have an effect on human walking activities. The 3D
foot scanning system was employed to obtain static footprints from subjects
adopting a half-weight-bearing stance. Based upon their footprints, the
subjects were divided into two groups: the flat-footed and the high-arched. The
plantar pressure measurement system was used to measure and record the
subjects' successive natural gaits. Two indices were proposed: distribution of
vertical ground reaction force (VGRF) of plantar and the rate of the footprint
areas. Using these two indices to compare the natural gaits of the two subject
groups, we found that (1) in stance phase, there is a significant difference
(p<0.01) in the distributions of VGRF of plantar; (2) in a stride cycle, there
is also a significant difference (p<0.01) in the rates of the footprint areas.
Our analysis suggests that when walking, the VGRF of the plantar brings greater
muscle tension to the flat-footed while a smaller rate of the footprint areas
brings greater stability to the high-arched.Comment: 8 pages, 4 figure
The Mediating Role of Resilience and Self-Esteem Between Life Events and Coping Styles Among Rural Left-Behind Adolescents in China: A Cross-Sectional Study
Objective: This study aims to explore the association between life events and coping styles, and how resilience and self-esteem mediate the association.Methods: A cross-sectional study was conducted among 981 left-behind adolescents (LBAs) in five junior high schools in Hunan Province, China, from April 13 to April 20, 2020. We utilized self-designed sociodemographic questionnaire, Adolescent Self-Rating Life Events Checklist, Resilience Scale Chinese Adolescent, Rosenberg Self-Esteem Scale, and Simplified Coping Style Questionnaire to assess the mental health of LBAs. Statistic description, Pearson correlation analysis, and structural equation model were adopted to analyze the data.Results: Results revealed that life events could negatively predict resilience (beta = -0.29, P < 0.001) and self-esteem (beta = -0.39, P < 0.001) and positively predict LBAs' positive coping style (beta = 0.28, P < 0.001) and negative coping style (beta = 0.21, P < 0.001). Self-esteem could also positively predict the resilience of LBAs (beta = 0.62, P < 0.001); resilience could negatively predict the negative coping style (beta = -0.21, P < 0.001) and positively predict the positive coping style (beta = 0.79, P < 0.001). Life events not only have direct effects on negative coping style (beta = 0.21) and positive coping style (beta = 0.28) but also have indirect effects on coping styles by affecting resilience (beta = -0.29) and self-esteem (beta = -0.39). The total effect of life events on coping styles was 0.32, where 34.37% was mediated by resilience and self-esteem.Conclusion: We proved that resilience and self-esteem mediated most of the effects of life events on coping styles. The findings had important implications for interventions to promote mental health of LBAs, particularly the enhancement of resilience and self-esteem
Towards the clinical implementation of pharmacogenetics in bipolar disorder.
BackgroundBipolar disorder (BD) is a psychiatric illness defined by pathological alterations between the mood states of mania and depression, causing disability, imposing healthcare costs and elevating the risk of suicide. Although effective treatments for BD exist, variability in outcomes leads to a large number of treatment failures, typically followed by a trial and error process of medication switches that can take years. Pharmacogenetic testing (PGT), by tailoring drug choice to an individual, may personalize and expedite treatment so as to identify more rapidly medications well suited to individual BD patients.DiscussionA number of associations have been made in BD between medication response phenotypes and specific genetic markers. However, to date clinical adoption of PGT has been limited, often citing questions that must be answered before it can be widely utilized. These include: What are the requirements of supporting evidence? How large is a clinically relevant effect? What degree of specificity and sensitivity are required? Does a given marker influence decision making and have clinical utility? In many cases, the answers to these questions remain unknown, and ultimately, the question of whether PGT is valid and useful must be determined empirically. Towards this aim, we have reviewed the literature and selected drug-genotype associations with the strongest evidence for utility in BD.SummaryBased upon these findings, we propose a preliminary panel for use in PGT, and a method by which the results of a PGT panel can be integrated for clinical interpretation. Finally, we argue that based on the sufficiency of accumulated evidence, PGT implementation studies are now warranted. We propose and discuss the design for a randomized clinical trial to test the use of PGT in the treatment of BD
Activation of cGMP-Dependent Protein Kinase Stimulates Cardiac ATP-Sensitive Potassium Channels via a ROS/Calmodulin/CaMKII Signaling Cascade
) channels, an ion channel critical for stress adaptation in the heart; however, the underlying mechanism remains largely unknown. The present study was designed to address this issue. channels was confirmed in intact ventricular cardiomyocytes, which was ROS- and CaMKII-dependent. Kinetically, PKG appeared to stimulate these channels by destabilizing the longest closed state while stabilizing the long open state and facilitating opening transitions. channels and contribute to cardiac protection against ischemia-reperfusion injury
Regulatory feedback response mechanisms to phosphate starvation in rice
Phosphorus is a growth-limiting nutrient for plants. The growing scarcity of phosphate stocks threatens global food security. Phosphate-uptake regulation is so complex and incompletely known that attempts to improve phosphorus use efficiency have had extremely limited success. This study improves our understanding of the molecular mechanisms underlying phosphate uptake by investigating the transcriptional dynamics of two regulators: the Ubiquitin ligase PHO2 and the long non-coding RNA IPS1. Temporal measurements of RNA levels have been integrated into mechanistic mathematical models using advanced statistical techniques. Models based solely on current knowledge could not adequately explain the temporal expression profiles. Further modeling and bioinformatics analysis have led to the prediction of three regulatory features: the PHO2 protein mediates the degradation of its own transcriptional activator to maintain constant PHO2 mRNA levels; the binding affinity of the transcriptional activator of PHO2 is impaired by a phosphate-sensitive transcriptional repressor/inhibitor; and the extremely high levels of IPS1 and its rapid disappearance upon Pi re-supply are best explained by Pi-sensitive RNA protection. This work offers both new opportunities for plant phosphate research that will be essential for informing the development of phosphate efficient crop varieties, and a foundation for the development of models integrating phosphate with other stress responses
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