Definition, analysis and development of an optical data distribution network for integrated avionics and control systems. Part 2: Component development and system integration

Fiber optic transmission is emerging as an attractive concept in data distribution onboard civil aircraft. Development of an Optical Data Distribution Network for Integrated Avionics and Control Systems for commercial aircraft will provide a data distribution network that gives freedom from EMI-RFI and ground loop problems, eliminates crosstalk and short circuits, provides protection and immunity from lightning induced transients and give a large bandwidth data transmission capability. In addition there is a potential for significantly reducing the weight and increasing the reliability over conventional data distribution networks. Wavelength Division Multiplexing (WDM) is a candidate method for data communication between the various avionic subsystems. With WDM all systems could conceptually communicate with each other without time sharing and requiring complicated coding schemes for each computer and subsystem to recognize a message. However, the state of the art of optical technology limits the application of fiber optics in advanced integrated avionics and control systems. Therefore, it is necessary to address the architecture for a fiber optics data distribution system for integrated avionics and control systems as well as develop prototype components and systems

Electron microscopic visualization of tRNA genes with ferritin-avidin: biotin labels

A method is described for indirect electron microscopic visualization and mapping of tRNA and other short transcripts hybridized to DNA. This method depends upon the attachment of the electron-dense protein ferritin to the RNA, the binding being mediated by the remarkably strong association of the egg white protein avidin with biotin. Biotin is covalently attached to the 3' end of tRNA using an NH2 (CH2) 5NH2 bridge. The tRNA-biotin adduct is hybridized to complementcrry DNA sequences present in a single stranded nonhomology loop of a DNA:DNA heteroduplex. Avidin, covalently crosslinked to ferritin is mixed with the heteroduplex and becomes bound to the hybridized tRNA-biotin. Observation of the DNA:RNA-biotin:avidin-ferritin complex by electron microsdopy specifically and accurately reveals the position of the tRNA gene, with a frequency of labeling of approximately 50%

A short note on the presence of spurious states in finite basis approximations

The genesis of spurious solutions in finite basis approximations to operators which possess a continuum and a point spectrum is discussed and a simple solution for identifying these solutions is suggested

Second Cluster Integral and Excluded Volume Effects for the Pion Gas

The quantum mechanical formula for Mayer's second cluster integral for the gas of relativistic particles with hard-core interaction is derived. The proper pion volume calculated with quantum mechanical formula is found to be an order of magnitude larger than its classical evaluation. The second cluster integral for the pion gas is calculated in quantum mechanical approach with account for both attractive and hard-core repulsive interactions. It is shown that, in the second cluster approximation, the repulsive pion-pion-interactions as well as the finite width of resonances give important but almost canceling contributions. In contrast, an appreciable deviation from the ideal gas of pions and pion resonances is observed beyond the second cluster approximation in the framework of the Van der Waals excluded-volume model.Comment: 29 pages, Latex, 9 PS-figure

Temperature variation of total hemispherical emissivity of stainless steel AISI 304

[[abstract]]Numerical values of the total hemispherical emissivities Eh of a mechanically polished surface and an electropolished surface of a sample of stainless steel, type AISI 304, have been determined experimentally for the first time in the temperature range 340-1100 K. An absolute method incorporating the transient calorimetric principle was used in these measurements. It is found that the 4Eh values obtained are only very slightly different from those predicted by a classical expression for total hemispherical emissivity developed by Davisson and Weeks.[[notice]]補正完畢[[booktype]]紙

In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.

BackgroundCruzain, the major cysteine protease of Trypanosoma cruzi, is an essential enzyme for the parasite life cycle and has been validated as a viable target to treat Chagas' disease. As a proof-of-concept, K11777, a potent inhibitor of cruzain, was found to effectively eliminate T. cruzi infection and is currently a clinical candidate for treatment of Chagas' disease.Methodology/principal findingsWRR-483, an analog of K11777, was synthesized and evaluated as an inhibitor of cruzain and against T. cruzi proliferation in cell culture. This compound demonstrates good potency against cruzain with sensitivity to pH conditions and high efficacy in the cell culture assay. Furthermore, WRR-483 also eradicates parasite infection in a mouse model of acute Chagas' disease. To determine the atomic-level details of the inhibitor interacting with cruzain, a 1.5 A crystal structure of the protease in complex with WRR-483 was solved. The structure illustrates that WRR-483 binds covalently to the active site cysteine of the protease in a similar manner as other vinyl sulfone-based inhibitors. Details of the critical interactions within the specificity binding pocket are also reported.ConclusionsWe demonstrate that WRR-483 is an effective cysteine protease inhibitor with trypanocidal activity in cell culture and animal model with comparable efficacy to K11777. Crystallographic evidence confirms that the mode of action is by targeting the active site of cruzain. Taken together, these results suggest that WRR-483 has potential to be developed as a treatment for Chagas' disease

Van der Waals Excluded Volume Model of Multicomponent Hadron Gas

A generalization of the Van der Waals excluded volume procedure for the multicomponent hadron gas is proposed. The derivation is based on the grand canonical partition function for the system of particles of several species interacting by hard core potentials. The obtained formulae for thermodynamical quantities are consistent with underlying principles of statistical mechanics as well as with thermodynamical identities. The model can be applied to the analysis of experimental data for particle number ratios in relativistic nucleus-nucleus collisions.Comment: 8 page

Breakdown of Conformal Invariance at Strongly Random Critical Points

We consider the breakdown of conformal and scale invariance in random systems with strongly random critical points. Extending previous results on one-dimensional systems, we provide an example of a three-dimensional system which has a strongly random critical point. The average correlation functions of this system demonstrate a breakdown of conformal invariance, while the typical correlation functions demonstrate a breakdown of scale invariance. The breakdown of conformal invariance is due to the vanishing of the correlation functions at the infinite disorder fixed point, causing the critical correlation functions to be controlled by a dangerously irrelevant operator describing the approach to the fixed point. We relate the computation of average correlation functions to a problem of persistence in the RG flow.Comment: 9 page