Evaluation of bacteria for biological control of early blightdisease of tomato

Twenty three bacterial isolate out of 190, exhibiting inhibitory affects against Alternaria solani in preliminary tests, were screened for their activity towards A. solani Ell. and G. Martin) Sor. by a dualculture in vitro assay on nutrient agar (NA) medium and in vivo (whole plant) test. In vitro studies indicated that all the 23 bacterial isolates inhibited the mycelial growth of A. solani by forming inhibition zone ranging from 9.35 to 31.3 mm. The most effective isolate was Serratia plymuthica (IK- 139) (31.3 mm) based on the in vitro test results. Twenty three bacterial isolates were subjected to a whole plant test to investigate their ability to protect the tomato plant against early blight disease. In whole plant tests, 0.5 x 108 cfu/ml bacterial suspension was sprayed and one day later, A. solani spores suspension were applied on tomato seedlings and plants were incubated in moist chamber at 20°C with 95% relative humidity (RH) and 12 h photoperiods for 21 days. Based on the whole plant tests, Paenibacillus macerans-GC subgroup A (1.82), Serratia plymuthica (1.78), Bacillus coagulans (1.75), Serratia marcescens-GC subgroup A (1.50), Bacillus pumilis –GC subgroup B (1.50) and Pantoea agglomerans (1.32) bacterial isolates reduced the disease severity of early blight significantly when compared with control. These results suggest that the bacterial isolates studied have a good potential to be used as biocontrol agents of A. solani in tomato.Key words: Alternaria solani, early blight, biological control, bacterial isolate

Nature of the spin resonance mode in CeCoIn5_5

Spin-fluctuation-mediated unconventional superconductivity can emerge at the border of magnetism, featuring a superconducting order parameter that changes sign in momentum space. Detection of such a sign-change is experimentally challenging, since most probes are not phase-sensitive. The observation of a spin resonance mode (SRM) from inelastic neutron scattering is often seen as strong phase-sensitive evidence for a sign-changing superconducting order parameter, by assuming the SRM is a spin-excitonic bound state. Here, we show that for the heavy fermion superconductor CeCoIn$_5$, its SRM defies expectations for a spin-excitonic bound state, and is not a manifestation of sign-changing superconductivity. Instead, the SRM in CeCoIn$_5$ likely arises from a reduction of damping to a magnon-like mode in the superconducting state, due to its proximity to magnetic quantum criticality. Our findings emphasize the need for more stringent tests of whether SRMs are spin-excitonic, when using their presence to evidence sign-changing superconductivity.Comment: accepted for publication in Communications Physic

Dealing with fuzziness in active mobile database systems

Current needs of industry required the development of advanced database models like active mobile database systems. An active mobile database system can be designed by incorporation of triggering rules into a mobile computing environment in which the users are able to access a collection of database services using mobile and non-mobile computers at any location. Fuzzy concepts are adapted to the field of databases in order to deal with ambiguous, uncertain data. Fuzziness comes into picture in active mobile databases especially with spatial queries on moving objects. Incorporating fuzziness into rules would also improve the effectiveness of active mobile databases as it provides much flexibility in defining rules for the supported application. In this paper we present some methods to adapt the concepts developed for fuzzy systems to active mobile databases

Robust Upward Dispersion of the Neutron Spin Resonance in the Heavy Fermion Superconductor Ce1−x_{1-x}Ybx_{x}CoIn5_5

The neutron spin resonance is a collective magnetic excitation that appears in copper oxide, iron pnictide, and heavy fermion unconventional superconductors. Although the resonance is commonly associated with a spin-exciton due to the $d$($s^{\pm}$)-wave symmetry of the superconducting order parameter, it has also been proposed to be a magnon-like excitation appearing in the superconducting state. Here we use inelastic neutron scattering to demonstrate that the resonance in the heavy fermion superconductor Ce$_{1-x}$Yb$_{x}$CoIn$_5$ with $x=0,0.05,0.3$ has a ring-like upward dispersion that is robust against Yb-doping. By comparing our experimental data with random phase approximation calculation using the electronic structure and the momentum dependence of the $d_{x^2-y^2}$-wave superconducting gap determined from scanning tunneling microscopy for CeCoIn$_5$, we conclude the robust upward dispersing resonance mode in Ce$_{1-x}$Yb$_{x}$CoIn$_5$ is inconsistent with the downward dispersion predicted within the spin-exciton scenario.Comment: Supplementary Information available upon reques

Structural insights on TRPV5 gating by endogenous modulators.

TRPV5 is a transient receptor potential channel involved in calcium reabsorption. Here we investigate the interaction of two endogenous modulators with TRPV5. Both phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and calmodulin (CaM) have been shown to directly bind to TRPV5 and activate or inactivate the channel, respectively. Using cryo-electron microscopy (cryo-EM), we determined TRPV5 structures in the presence of dioctanoyl PI(4,5)P2 and CaM. The PI(4,5)P2 structure reveals a binding site between the N-linker, S4-S5 linker and S6 helix of TRPV5. These interactions with PI(4,5)P2 induce conformational rearrangements in the lower gate, opening the channel. The CaM structure reveals two TRPV5 C-terminal peptides anchoring a single CaM molecule and that calcium inhibition is mediated through a cation-π interaction between Lys116 on the C-lobe of calcium-activated CaM and Trp583 at the intracellular gate of TRPV5. Overall, this investigation provides insight into the endogenous modulation of TRPV5, which has the potential to guide drug discovery

"London is avocado on toast” : the urban imaginaries of the #LondonIsOpen campaign

This article examines the production, representations, and reactions to the #LondonIsOpen campaign to ask how urban imaginaries are produced and what they entail for understanding the city. The analysis considers how the idea of a cosmopolitan, diverse, and multicultural city is framed, what it includes and excludes, and the distinct geographies of the city it produces. It draws on three data sources: documentary analysis of videos used in the campaign; social media analysis of tweets using #LondonIsOpen; and semi-structured interviews with key figures in the campaign team. The main arguments are that the appeal to openness contributes to the versatility of the campaign and the range of responses to it, making it highly adaptable and flexible to respond to current affairs; and that open London is geographically selective and imagined as business focused; trendy; and cosmopolitan. In turn, the reactions to the idea of open London range from seeking a borderless world to anti-migrant rhetoric. Although the campaign represents London as welcoming and inclusive, such welcoming is partial and subject to contestation. The article concludes that over time, the openness of #LondonIsOpen has come to serve multiple political functions and act as a brand for the city