Selenium Levels in Human Erythrocyte, Saliva, Milk, Urine and Nail (B. LIVING SCIENCE)

ヒトの赤血球, 唾液, 初乳, 成乳, 尿, 爪のセレン(Se), 蛋白質(関連物費を含む。以後は, この説明文は省略する。), 脂肪濃度を測定した。唾液, 成乳のSeと蛋白質の濃度の間, 及び成乳のSeと脂肪の濃度の間に低い負の相関係数が見出された。赤血球, 初乳, 尿のSeと蛋白質の濃度間にも高い正の相関が示された。すべての組織において, Seと蛋白質の濃度間の高い(低い)正の(負の)相関係数は, 容量当りの含量で表わされた平均Seレベルの変動係数よりも低い(高い)蛋白質(脂肪を含む)含量当りの平均Seレベルの変動係数と完全に対応した。Seレベルを蛋白質含量当りの含量で表わすと, 尿中Seは赤血球Se, 唾液Seと高い負の相関を示し, 初乳Seと高い正の相関係数をもたらした。赤血球Seと唾液Seの間にも高い正の相関係数が見出された。組織間の平均Seレベルは, 組織容量(又は重量)当りの含量で表わせば, 爪>赤血球>尿>初乳>成乳>唾液の順に減少し, 又組織蛋白質含量当りの含量で表わせば, 尿>唾液>成乳>初乳>赤血球の順序で減少した。各組織のSeレベルは文献値とかなり類似した。これらの結果は, ヒトに対するSeの必須機能についての支持を与えるものである。Selenium, protein (or related substances) and lipid concentrations were measured for human erythrocyte, saliva, colostral and mature milk, urine and nail samples. Low negative correlation coefficients were produced between selenium and protein concentrations in saliva and mature milk and between selenium and lipid concentrations in mature milk. In erythrocyte, colostral milk and urine, high positive correlations were found between selenium and protein (or related substances). In all individual tissues examined, high (low) and positive (negative) correlation coefficients between selenium and protein (or related substances, lipid) concentrations corresponded thoroughly to lower (higher) variation coefficients of average selenium levels expressed as content per content of tissue protein (or related substances, lipid) than that per tissue volume. When selenium levels were expressed in content per protein (or related substances) content, urine selenium produced high negative correlations with erythrocyte and saliva selenium, and high positive correlation coefficient with colostral milk selenium. High positive correlation coefficient was also found between erythrocyte and saliva selenium. Average selenium levels decreased in the order, nail > erythrocyte > urine > colostral milk > mature milk > saliva when expressed in content per tissue volume (or weight), and, in the order, urine > saliva > mature milk > colostral milk > erythrocyte when expressed in content per tissue protein (or related substances) content. Selenium levels for individual tissues examined were considerably similar to values from literatures. These results give a support to essential function of selenium element for human beings

チオール配位子と, 有機水銀およびクロムとの相互作用に関する研究

京都大学0048新制・課程博士薬学博士甲第1709号薬博第138号新制||薬||74(附属図書館)4756UT51-61-I182京都大学大学院薬学研究科製薬化学専攻(主査)教授 田中 久, 教授 宇野 豊三, 教授 大崎 健次学位規則第5条第1項該当Kyoto UniversityDA