Refinement of Interval Approximations for Fully Commutative Quivers

A fundamental challenge in multiparameter persistent homology is the absence of a complete and discrete invariant. To address this issue, we propose an enhanced framework that realizes a holistic understanding of a fully commutative quiver's representation via synthesizing interpretations obtained from intervals. Additionally, it provides a mechanism to tune the balance between approximation resolution and computational complexity. This framework is evaluated on commutative ladders of both finite-type and infinite-type. For the former, we discover an efficient method for the indecomposable decomposition leveraging solely one-parameter persistent homology. For the latter, we introduce a new invariant that reveals persistence in the second parameter by connecting two standard persistence diagrams using interval approximations. We subsequently present several models for constructing commutative ladder filtrations, offering fresh insights into random filtrations and demonstrating our toolkit's effectiveness in analyzing the topology of materials

Optimally Computing Compressed Indexing Arrays Based on the Compact Directed Acyclic Word Graph

In this paper, we present the first study of the computational complexity of converting an automata-based text index structure, called the Compact Directed Acyclic Word Graph (CDAWG), of size $e$ for a text $T$ of length $n$ into other text indexing structures for the same text, suitable for highly repetitive texts: the run-length BWT of size $r$, the irreducible PLCP array of size $r$, and the quasi-irreducible LPF array of size $e$, as well as the lex-parse of size $O(r)$ and the LZ77-parse of size $z$, where $r, z \le e$. As main results, we showed that the above structures can be optimally computed from either the CDAWG for $T$ stored in read-only memory or its self-index version of size $e$ without a text in $O(e)$ worst-case time and words of working space. To obtain the above results, we devised techniques for enumerating a particular subset of suffixes in the lexicographic and text orders using the forward and backward search on the CDAWG by extending the results by Belazzougui et al. in 2015.Comment: The short version of this paper will appear in SPIRE 2023, Pisa, Italy, September 26-28, 2023, Lecture Notes in Computer Science, Springe

The β1-integrin-dependent function of RECK in physiologic and tumor angiogenesis

金沢大学がん研究所Vascular endothelial cells produce considerable amounts of matrix metalloproteinases (MMP), including MMP-2, MMP-9, and membrane type 1 (MT1)-MMP. However, little is known about the regulatory mechanisms of these protease activities exhibited during vascular development. A glycosylphosphatidylinositol-anchored glycoprotein, reversion-inducing cysteine-rich protein with Kazal motifs (RECK), has been shown to attenuate MMP-2 maturation by directly interacting with MT1-MMP. Here, we show that an angiogenic factor angiopoietin-1 induces RECK expression in human umbilical vein endothelial cells (HUVEC), and RECK depletion in these cells results in defective vascular tube formation and cellular senescence. We further observed that RECK depletion downregulates β1-integrin activation, which was associated with decreased autophosphorylation of focal adhesion kinase and increased expression of a cyclin-dependent kinase inhibitor p21CIP1. In agreement, significant downregulation of β1-integrin activity was observed in vascular endothelial cells in Reck-/- mouse embryos. In HUVECs, specific inhibition of MMP-2 significantly antagonized the effect of RECK depletion on β1-integrin signaling, cell proliferation, and tube elongation. Furthermore, we observed that hypervascular tumor-derived cell lines can induce high RECK expression in convoluted vascular endothelial cells, and this in turn supports tumor growth. Targeting RECK specifically in tumor-associated vascular endothelial cells resulted in tumor regression. Therefore, we propose that RECK in tumor vascular endothelial cells can be an interesting target of cancer treatment via abortion of tumor angiogenesis. ©2010 AACR

九大病院におけるアジア遠隔医療システムの基盤整備

平成17年度大学病院情報マネジメント部門連絡会議 : 平成18年1月26日(木)～27日(金) : 静

Predictive factors of mortality of patients with fragility hip fractures at 1 year after discharge : A multicenter, retrospective study in the northern Kyushu district of Japan

Purpose: Fragility hip fractures (FHFs) are associated with a high risk of mortality, but the relative contribution of various factors remains controversial. This study aimed to evaluate predictive factors of mortality at 1 year after discharge in Japan. Methods: A total of 497 patients aged 60 years or older who sustained FHFs during follow-up were included in this study. Expected variables were finally assessed using multivariable Cox proportional hazards models. Results: The 1-year mortality rate was 9.1% (95% confidence interval: 6.8–12.0%, n = 45). Log-rank test revealed that previous fractures (p = 0.003), Barthel index (BI) at discharge (p = 0.011), and place-to-discharge (p = 0.004) were significantly associated with mortality for male patients. Meanwhile, body mass index (BMI; p = 0.023), total Charlson comorbidity index (TCCI; p = 0.005), smoking (p = 0.007), length of hospital stay (LOS; p = 0.009), and BI (p = 0.004) were the counterparts for females. By multivariate analyses, previous vertebral fractures (hazard ratio (HR) 3.33; p = 0.044), and BI <30 (HR 5.42, p = 0.013) were the predictive variables of mortality for male patients. BMI <18.5 kg/m2 (HR 2.70, p = 0.023), TCCI ≥5 (HR 2.61, p = 0.032), smoking history (HR 3.59, p = 0.018), LOS <14 days (HR 13.9; p = 0.007), and BI <30 (HR 2.76; p = 0.049) were the counterparts for females. Conclusions: Previous vertebral fractures and BI <30 were the predictive variables of mortality for male patients, and BMI <18.5 kg/m2, TCCI ≥5, smoking history, LOS <14 days, and BI <30 were those for females. Decreased BI is one of the independent and preventable risk factors. A comprehensive therapeutic approach should be considered to prevent deterioration of activities of daily living and a higher risk of mortality

Emerging Technologies for Telemedicine

This paper focuses on new technologies that are practically useful for telemedicine. Three representative systems are introduced: a Digital Video Transport System (DVTS), an H.323 compatible videoconferencing system, and Vidyo. Based on some of our experiences, we highlight the advantages and disadvantages of each technology, and point out technologies that are especially targeted at doctors and technicians, so that those interested in using similar technologies can make appropriate choices and achieve their own goals depending on their specific conditions

<症例>肝臓原発の良性神経鞘腫

Neurogenic tumors of the liver are very rare, irrespective of associated neurofibromatosis. We report here a well-documented case of benign schwannoma in a 56-year-old woman without neurofibromatosis, including imaging and pathological examinations.肝臓に発生する神経原性腫瘍は神経線維腫症(von Recklinghausen 病)の有無にかかわらず, 稀な疾患である. 我々は, 56歳の神経線維腫症でない女性の肝臓内に発生した良性神経鞘腫の症例を経験したので, 画像診断, 病理学的検査を含めて報告する

Coupled analysis of unsteady aerodynamics and vehicle motion of a road vehicle in windy conditions

The two-way coupling of full-scale vehicle motion and the surrounding turbulence motion has been realized on a developed unsteady aerodynamic simulator for a road vehicle. A large-eddy simulation (LES) technique has been applied to reproduce the unsteady turbulence motion, and an unstructured finite volume method has been adopted to explain the complicated geometry of a full-scale road vehicle. Three-degree-of-freedom equations of the vehicle's dynamic motion are incorporated into the developed LES code, and the motion is numerically reproduced by coupling the arbitrary Lagrangian Eulerian (ALE) method and Navier-Stokes equations in a non-inertial reference frame. The simulation code is implemented on a massively parallel processor to meet the demands of the large-scale, long-term aerodynamic simulations of full-scale road vehicles. As a typical application of the coupled analysis, an unsteady aerodynamics simulation of a simplified heavy-duty truck in windy conditions is demonstrated, and the effects of the unsteady aerodynamics on the truck's motion are investigated. The obtained results are compared with the results of a conventional quasi-steady analysis, and certain differences in the vehicle path and the yaw angle are identified. The effects of the transitional aerodynamics on variables related to driver's perception are significant. These results clearly indicate the importance of estimating the unsteady aerodynamic forces in a vehicle motion analysis. (C) 2012 Elsevier Ltd. All rights reserved