Research on the Current Situation and Strategies for Enhancing the Development and Capacity of Food Safety Inspection and Testing Institutions ——A Case Study of Zhejiang Province

Food is vital to the people, and safety comes first in food. Food safety is crucial to people's livelihood, economic development, and social stability. It represents people's aspiration for a better life and grabs great public attention. In recent years, while China has achieved significant progress in food safety, the situation remains severe, with incidents such as excessive residues of agricultural and veterinary drugs, as well as illegal addition of toxic and harmful substances. As an important technical support for ensuring food safety, food safety inspection and testing institutions also exhibit a mixed bag of performance. Problems such as inadequate personnel management, improper use of facilities and equipment, weak legal awareness resulting in issuance of false reports have frequently occurred, seriously disrupting the normal order of the inspection and testing market and affecting the authority and accuracy of food safety testing. Based on the capacity verification of inspection and testing organizations in Zhejiang Province in recent years, this paper studies the typical problems faced by food inspection and testing institutions in terms of management level and testing capabilities, analyzes the root causes in depth, and proposes specific strategies from three aspects: Strengthening the main responsibility of inspection and testing institutions, combining regulatory departments with supervision and guidance, and enhancing industry self-discipline, aiming to continuously improve their inspection and testing capabilities, promote the high-quality development of food inspection and testing institutions, and effectively ensure the safety of every bite of food

The clinical relevance of oliguria in the critically ill patient : Analysis of a large observational database

Funding Information: Marc Leone reports receiving consulting fees from Amomed and Aguettant; lecture fees from MSD, Pfizer, Octapharma, 3 M, Aspen, Orion; travel support from LFB; and grant support from PHRC IR and his institution. JLV is the Editor-in-Chief of Critical Care. The other authors declare that they have no relevant financial interests. Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Urine output is widely used as one of the criteria for the diagnosis and staging of acute renal failure, but few studies have specifically assessed the role of oliguria as a marker of acute renal failure or outcomes in general intensive care unit (ICU) patients. Using a large multinational database, we therefore evaluated the occurrence of oliguria (defined as a urine output 16 years) patients in the ICON audit who had a urine output measurement on the day of admission were included. To investigate the association between oliguria and mortality, we used a multilevel analysis. Results: Of the 8292 patients included, 2050 (24.7%) were oliguric during the first 24 h of admission. Patients with oliguria on admission who had at least one additional 24-h urine output recorded during their ICU stay (n = 1349) were divided into three groups: transient - oliguria resolved within 48 h after the admission day (n = 390 [28.9%]), prolonged - oliguria resolved > 48 h after the admission day (n = 141 [10.5%]), and permanent - oliguria persisting for the whole ICU stay or again present at the end of the ICU stay (n = 818 [60.6%]). ICU and hospital mortality rates were higher in patients with oliguria than in those without, except for patients with transient oliguria who had significantly lower mortality rates than non-oliguric patients. In multilevel analysis, the need for RRT was associated with a significantly higher risk of death (OR = 1.51 [95% CI 1.19-1.91], p = 0.001), but the presence of oliguria on admission was not (OR = 1.14 [95% CI 0.97-1.34], p = 0.103). Conclusions: Oliguria is common in ICU patients and may have a relatively benign nature if only transient. The duration of oliguria and need for RRT are associated with worse outcome.publishersversionPeer reviewe

Vibration reduction in beam bridge under moving loads using nonlinear smooth and discontinuous oscillator

The coupled system of smooth and discontinuous absorber and beam bridge under moving loads is constructed in order to detect the effectiveness of smooth and discontinuous absorber. It is worth pointing out that the coupled system contains an irrational restoring force which is a barrier for conventional nonlinear techniques. Hence, the harmonic balance method and Fourier expansion are used to obtain the approximate solutions of the system. The first and the second kind of generalized complete elliptic integrals are introduced. Furthermore, using power flow approach, the performance of smooth and discontinuous absorber in vibration reduction is estimated through the input energy, the dissipated energy, and the damping efficiency. It is interesting that only depending on the value of the smoothness parameter, the efficiency parameter of vibration reduction is optimized. Therefore, smooth and discontinuous absorber can adapt itself to effectively reducing the amplitude of the vibration of the beam bridge, which provides an insight to the understanding of the applications of smooth and discontinuous oscillator in engineering and power flow characteristics in nonlinear system

Effect of solid content on structure and properties of alumina ceramic matrix composite prepared by slurry infiltration method

Alumina fiber reinforced alumina ceramic matrix composites possess high temperature resistance, high strength and oxidation resistance, etc, and have a considerable application prospects in the field of thermal structural materials used in aerospace. Using NextelTM 610 fabric as the reinforcement, alumina ceramic matrix composites were prepared by Slurry Infiltration-molding process and sintered in a muffle furnace at high temperature for one time. The temperature range suitable for the preparation of composites was determined by the effects of heat treatment temperature on the crystalline phase, mechanical strength and other properties of fiber and matrix. The effects of solid content on the mechanical properties and microstructure of the composites were studied. The results show that the bending strength of NextelTM 610/Al2O3 ceramic matrix composite increases first and then decreases with the increase of solid content. When the solid content of the slurry is 60% (mass fraction, the same below), the bending strength is the largest, up to 370.68 MPa. When the solid content is less than 60%, the reason why the flexural strength of the composite is low is that the matrix in the fiber bundles is not filled enough. When the solid content increases to 65%, the degradation of the flexural strength of the composite is due to the formation of too many matrix defects and the strengthening of the fiber-matrix interface, which hinders the fiber debonding, pull-out and other toughening mechanisms

Impact of direct-acting antivirals on de novo occurrence of hepatocellular carcinoma in hepatitis C virus patients

Hepatitis C Virus (HCV) infection constitutes a significant burden to world health, leading to liver cirrhosis and hepatocellular carcinoma (HCC). In the past decades, pegylated interferon combined with ribavirin has been used extensively for HCV treatment, and interferon (IFN) is thought to have antitumor property. Direct-acting antivirals (DAAs) have fundamentally changed HCV therapy, due to their high efficacy and tolerability. However, recent studies have reported relatively high rates of HCC occurrence, and recurrence, following successful HCV treatment using DAAs. These studies were grossly underpowered due to their retrospective design, lack of untreated or IFN controls, small sample size, and limited patient follow-up time. From then, many retrospective and prospective cohort studies with larger size and longer follow-up duration after DAAs therapy have been published. These studies showed that treatment with DAAs can reduce the risk of HCC compared to no treatment, didn’t increase the risk of HCC compared to IFN-based therapy after adjusting for the potential confounders of these two groups, and DAAs-induced sustained virological response decreased the risk of HCC compared to DAAs treatment failure. In conclusion, DAAs treatment doesn’t appear to increase the development of HCC, even in cirrhotic patients. However, cirrhotic patients should be monitored for the development of HCC during and after DAAs treatment

Research and Application of Satellite Integration Design Based on MBD

As satellite integration design and implementation become more and more complex and difficult, a MBD model structure suit for satellite integration design is proposed in this paper, to ensure data consistency and the design work more efficiency. In order to help designers build normative MBD model efficient, a rapid MBD modeling tool has been developed and already been validated in several satellite development projects

Bifurcations and chaotic thresholds for the spring-pendulum oscillator with irrational and fractional nonlinear restoring forces

Nonlinear dynamical systems with irrational and fractional nonlinear restoring forces often occur in both science and engineering, and always lead to a barrier for conventional nonlinear techniques. In this paper, we have investigated the global bifurcations and the chaos directly for a nonlinear system with irrational and fractional nonlinear restoring forces avoiding the conventional Taylor’s expansion to retain the natural characteristics of the system. By introducing a particular dimensionless representation and a series of transformations, the two-degree-of-freedom system can be transformed into a perturbed Hamiltonian system. The extended Melnikov method is directly used to detect the chaotic threshold of the perturbed system theoretically, which overcomes the barrier caused by solving theoretical solution for the homoclinic orbit of the unperturbed system. The numerical simulations are carried out to demonstrate the complicated dynamics of the nonlinear spring-pendulum system, which show the efficiency of the criteria for chaotic motion in the system.<br/

Differentiation between bipolar disorder and major depressive disorder in adolescents: from clinical to biological biomarkers

BackgroundMood disorders are very common among adolescents and include mainly bipolar disorder (BD) and major depressive disorder (MDD), with overlapping depressive symptoms that pose a significant challenge to realizing a rapid and accurate differential diagnosis in clinical practice. Misdiagnosis of BD as MDD can lead to inappropriate treatment and detrimental outcomes, including a poorer ultimate clinical and functional prognosis and even an increased risk of suicide. Therefore, it is of great significance for clinical management to identify clinical symptoms or features and biological markers that can accurately distinguish BD from MDD. With the aid of bibliometric analysis, we explore, visualize, and conclude the important directions of differential diagnostic studies of BD and MDD in adolescents.Materials and methodsA literature search was performed for studies on differential diagnostic studies of BD and MDD among adolescents in the Web of Science Core Collection database. All studies considered for this article were published between 2004 and 2023. Bibliometric analysis and visualization were performed using the VOSviewer and CiteSpace software.ResultsIn total, 148 publications were retrieved. The number of publications on differential diagnostic studies of BD and MDD among adolescents has been generally increasing since 2012, with the United States being an emerging hub with a growing influence in the field. Boris Birmaher is the top author in terms of the number of publications, and the Journal of Affective Disorders is the most published journal in the field. Co-occurrence analysis of keywords showed that clinical characteristics, genetic factors, and neuroimaging are current research hotspots. Ultimately, we comprehensively sorted out the current state of research in this area and proposed possible research directions in future.ConclusionThis is the first-ever study of bibliometric and visual analyses of differential diagnostic studies of BD and MDD in adolescents to reveal the current research status and important directions in the field. Our research and analysis results might provide some practical sources for academic scholars and clinical practice