The Longitudinal Variation of Equatorial Waves due to Propagation on a Varying Zonal Flow

The general 1D theory of waves propagating on a zonally varying flow is developed from basic wave theory, and equations are derived for the variation of wavenumber and energy along ray paths. Different categories of behavior are found, depending on the sign of the group velocity cg and a wave property B. For B positive, the wave energy and the wavenumber vary in the same sense, with maxima in relative easterlies or westerlies, depending on the sign of cg. Also the wave accumulation of Webster and Chang occurs where cg goes to zero. However, for B negative, they behave in opposite senses and wave accumulation does not occur. The zonal propagation of the gravest equatorial waves is analyzed in detail using the theory. For nondispersive Kelvin waves, B reduces to 2, and an analytic solution is possible. For all the waves considered, B is positive, except for the westward-moving mixed Rossby–gravity (WMRG) wave, which can have negative B as well as positive B. Comparison is made between the observed climatologies of the individual equatorial waves and the result of pure propagation on the climatological upper-tropospheric flow. The Kelvin wave distribution is in remarkable agreement, considering the approximations made. Some aspects of the WMRG and Rossby wave distributions are also in qualitative agreement. However, the observed maxima in these waves in the winter westerlies in the eastern Pacific and Atlantic Oceans are generally not in accord with the theory. This is consistent with the importance of the sources of equatorial waves in these westerly duct regions due to higher-latitude wave activity

A role for peroxisome proliferator-activated receptors in the immunopathology of schistosomiasis?

Peroxisome proliferator-activated receptors (PPARs) have been demonstrated to have a role in immune regulation. In general, they are anti-inflammatory and promote Th2 type responses, and they are associated with the alternative activation of macrophages. Interestingly, helminth infections, such as the schistosome blood flukes that cause schistosomiasis, are characterised by a Th2 response and the accumulation of alternative activated macrophages. This would suggest that at some level, PPARs could have a role in the modulation of the immune response in schistosomiasis. This paper discusses possible areas where PPARs could have a role in this disease

Exposure variability and behaviour of indoor and outdoor air pollutants in primary schools in the United Kingdom

Copyright @ 2011 ISEEBackground and Aims: Current evidence suggests that exposure to common indoor air pollutants is associated with adverse health effects in children. This study was conducted to examine air quality in four primary schools in southern England, in order to establish daily, weekly and seasonal variability of pollutant concentrations within and between the schools, and to understand the behaviour of common indoor and outdoor air pollutants. Methods: Four primary schools were selected for the study, in urban, suburban and rural environments with diverse size and socioeconomic backgrounds. Air quality monitoring was conducted in three rounds (autumn, winter, summer) during the academic year 2009-2010. Each round involved monitoring continuously for one week in four locations of typical children’s exposure: generally three indoors and one outdoors. Measurements were carried out for particulate matter count for size range 0.5-5.0μm (PM0.5-5.0), carbon dioxide (CO2), carbon monoxide (CO), and nitrogen dioxide (NO2). Results: Findings revealed great variability in PM0.5-5.0 concentrations during the week and between rounds of measurements within each school, and between schools. CO concentrations were greatly variable for the suburban and rural schools. Little variability was seen for NO2 concentrations. CO2 levels differed during the day and between days and rounds in each school, and between schools, depending on the daily activity patterns of children and practice of ventilation. Linear regression models predicted indoor levels for PM0.5-5.0, CO and NO2, based on contribution of outdoor concentrations to the same pollutant, ventilation measured by CO2 concentrations and weather variables. Conclusions: Study findings showed variability in pollutant exposure levels between locations, days and seasons in each school, and between all four schools. These differences related to school building design and location, ventilation practices and children’s daily activities. These findings support the need for developing methodology for personal exposure assessment to air pollutants among school children

Separation and extraction of bridge dynamic strain data (in Chinese)

Through comparing the measured data of dynamic strains due to loading and temperature by the strain gauge and temperature sensor at the same location, the information in the strain data was divided into three parts in the frequency domain by using the defined index named PSD (power spectra density)- ratio. The three parts are dominated respectively by temperature varying, stresses and noises and can be distinguished from the determined values of the separatirix frequencies. Then a simple algorithm was developed to separate the three types of information, and to extract the strain caused mainly by structural stresses. As an application of the proposed method, the influence of strain deformation and noises. As an application of the proposed method, the influence of strain deformation and noises on the fatigue assessment was investigated based on the separated data. The results show that, the determined values of separatrix frequencies are valuable for the monitoring data from other bridges. The algorithm is a multi resolution and hierarchical method, which has been validated as a simple and effective method for data analyses, and is suitable for the compression and pre-processing of the great amount monitoring data and easy to be integrated in the SHM's (structural health monitoring)software system. The strain due to temperature varying attributes only a little to the errors of fatigue assessment. However, the noises or random disturbance existed in the monitoring data have much responsibility for the errors, the main reason is that the random disturbance shifts the real strain/stress amplitude picked up by real structural stress or strain

A CFD and FEM Approach to a Multicompartmental Poroelastic Model for CSF Production and Circulation with Applicationsin Hydrocephalus Treatment and Cerebral Oedema

This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community, www.nanopaprika.eu.This study introduces a Multiple-Network Poroelastic Theory (MPET) model, coupled with finite-volume based Computational fluid dynamics (CFD) for the purpose of studying, in detail, the effects of obstructing Cerebrospinal fluid (CSF) transport within an image-derived cerebral environment. The MPET representation allows the investigation of fluid transport between CSF, brain parenchyma and cerebral blood, in an integral and comprehensive manner. Key novelties of this model are the casting of multidimensional MPET in a Finite Element Method (FEM) framework, the amalgamation of anatomically accurate choroid plexuses with their feeding arteries and a simple relationship relaxing the constraint of a unique permeability for the CSF compartment. This model is used to demonstrate the impact of fourth ventricle outlet obstruction (FVOO). The implications of treating such a clinical condition with the aid of endoscopic third (ETV) and endoscopic fourth (EFV) ventriculostomy are considered. Finally, we outline the impact of the FEM based MPET framework in understanding oedema, and its ongoing evolution

Analysis of gas chromatography/mass spectrometry data for catalytic lignin depolymerization using positive matrix factorization

Various catalytic technologies are being developed to efficiently convert lignin into renewable chemicals. However, due to its complexity, catalytic lignin depolymerization often generates a wide and complex distribution of product compounds. Gas chromatography/mass spectrometry (GC-MS) is a common analytical technique to profile the compounds that comprise lignin depolymerization products. GC-MS is applied not only to determine the product composition, but also to develop an understanding of the catalytic reaction pathways and of the relationships among catalyst structure, reaction conditions, and the resulting compounds generated. Although a very useful tool, the analysis of lignin depolymerization products with GC-MS is limited by the quality and scope of the available mass spectral libraries and the ability to correlate changes in GC-MS chromatograms to changes in lignin structure, catalyst structure, and other reaction conditions. In this study, the GC-MS data of the depolymerization products generated from organosolv hybrid poplar lignin using a copper-doped porous metal oxide catalyst and a methanol/dimethyl carbonate co-solvent was analyzed by applying a factor analysis technique, positive matrix factorization (PMF). Several different solutions for the PMF model were explored. A 13-factor solution sufficiently explains the chemical changes occurring to lignin depolymerization products as a function of lignin, reaction time, catalyst, and solvent. Overall, seven factors were found to represent aromatic compounds, while one factor was defined by aliphatic compounds

Selective expansion of viral variants following experimental transmission of a reconstituted feline immunodeficiency virus quasispecies

Following long-term infection with virus derived from the pathogenic GL8 molecular clone of feline immunodeficiency virus (FIV), a range of viral variants emerged with distinct modes of interaction with the viral receptors CD134 and CXCR4, and sensitivities to neutralizing antibodies. In order to assess whether this viral diversity would be maintained following subsequent transmission, a synthetic quasispecies was reconstituted comprising molecular clones bearing envs from six viral variants and its replicative capacity compared in vivo with a clonal preparation of the parent virus. Infection with either clonal (Group 1) or diverse (Group 2) challenge viruses, resulted in a reduction in CD4+ lymphocytes and an increase in CD8+ lymphocytes. Proviral loads were similar in both study groups, peaking by 10 weeks post-infection, a higher plateau (set-point) being achieved and maintained in study Group 1. Marked differences in the ability of individual viral variants to replicate were noted in Group 2; those most similar to GL8 achieved higher viral loads while variants such as the chimaeras bearing the B14 and B28 Envs grew less well. The defective replication of these variants was not due to suppression by the humoral immune response as virus neutralising antibodies were not elicited within the study period. Similarly, although potent cellular immune responses were detected against determinants in Env, no qualitative differences were revealed between animals infected with either the clonal or the diverse inocula. However, in vitro studies indicated that the reduced replicative capacity of variants B14 and B28 in vivo was associated with altered interactions between the viruses and the viral receptor and co-receptor. The data suggest that viral variants with GL8-like characteristics have an early, replicative advantage and should provide the focus for future vaccine development

Baseline susceptibility and cross-resistance in aphis gossypii glover (Aphididae: Hemiptera) to phorate and sulfoxaflor

© 2013 State of New South Wales. Susceptible discriminating doses of phorate (0.2 g/L) and sulfoxaflor (0.01 g/L) against cotton aphid Aphis gossypii Glover were determined by laboratory bioassay where aphids were sprayed with insecticide with the aid of a Potter spray tower. All of the populations tested were susceptible to sulfoxaflor, and only a pirimicarb resistant strain had cross-resistance to phorate. If phorate is used as a side dressing in Australian cotton for insect control, neither pirimicarb, or any other chemical associated with insensitive acetylcholinesterase type one resistance, should be used as the first foliar spray for any subsequent aphid control

Cortical thickness in cocaine users: relationship to resting functional connectivity and cocaine use

Poster Presentation: no. 3092INTRODUCTION: In rats, cocaine alters dendritic morphology (1), a determinant of cortical thickness (CT). In humans, addiction vulnerability traits such as anxiety and impulsivity relate to CT (2, 3). In human cocaine users, CT differences have been noted (e.g.,(4)) but little has been done to elucidate network functioning related to these differences. Numerous studies have also noted resting state functional connectivity (rsFC) differences in cocaine users (5, 6); however, how these may relate to structural differences is unknown. We identify cortical thickness differences in cocaine users, then probe relationships to rsFC and use characteristics in order to ...postprin