Femtosecond Time-Bin Entangled Qubits for Quantum Communication

We create pairs of non-degenerate time-bin entangled photons at telecom wavelengths with ultra-short pump pulses. Entanglement is shown by performing Bell kind tests of the Franson type with visibilities of up to 91%. As time-bin entanglement can easily be protected from decoherence as encountered in optical fibers, this experiment opens the road for complex quantum communication protocols over long distances. We also investigate the creation of more than one photon pair in a laser pulse and present a simple tool to quantify the probability of such events to happen.Comment: 6 pages, 7 figure

Weak randomness completely trounces the security of QKD

In usual security proofs of quantum protocols the adversary (Eve) is expected to have full control over any quantum communication between any communicating parties (Alice and Bob). Eve is also expected to have full access to an authenticated classical channel between Alice and Bob. Unconditional security against any attack by Eve can be proved even in the realistic setting of device and channel imperfection. In this Letter we show that the security of QKD protocols is ruined if one allows Eve to possess a very limited access to the random sources used by Alice. Such knowledge should always be expected in realistic experimental conditions via different side channels

Blood/gas partition coefficients of halothane, isoflurane and sevoflurane in horse blood

Background. Blood/gas partition coefficients (λb/g) for volatile agents in horse blood are reported for halothane but not for isoflurane and sevoflurane. We measured the λb/g of halothane, isoflurane and sevoflurane in the blood of fasted horses. The correlation with age, weight and some haematological and biochemical variables was studied. The temperature correction factor for isoflurane solubility was calculated. Methods. Twenty‐four horses were randomly allocated to halothane (n=8), isoflurane (n=8) or sevoflurane (n=8). Blood samples were taken after 10 h' fasting. Calculation of λb/g was based on the measurement of anaesthetic partial pressures in blood at 37 °C, which was achieved with tonometer equilibration and headspace gas chromatography. Results. Mean λb/g was 1.66 (sd 0.06) for halothane, 0.92 (0.04) for isoflurane, and 0.47 (0.03) for sevoflurane. The λb/g values were all significantly lower than in humans (P<0.001). No correlation was found between λb/g and weight, age, haematocrit, plasma triglycerides, cholesterol or total bilirubin. The change in isoflurane solubility per 1 °C temperature increase was -2.63 (0.13)%. Conclusion. The λb/g values of halothane, isoflurane and sevoflurane in fasted horses are significantly lower than those reported in humans. The λb/g for halothane in this study agrees with values reported in the literature but a positive correlation with plasma triglycerides could not be confirmed. Knowledge of λb/g can refine models of anaesthetic uptake. Br J Anaesth 2003; 91: 276-

Controlled Quantum Secret Sharing

We present a new protocol in which a secret multiqubit quantum state $\ket{\Psi}$ is shared by $n$ players and $m$ controllers, where $\ket{\Psi}$ is the encoding state of a quantum secret sharing scheme. The players may be considered as field agents responsible for carrying out a task, using the secret information encrypted in $\ket{\Psi}$, while the controllers are superiors who decide if and when the task should be carried out and who to do it. Our protocol only requires ancillary Bell states and Bell-basis measurements.Comment: 6 pages, 0 figure, RevTeX4; published version with minor change

High rate, long-distance quantum key distribution over 250km of ultra low loss fibres

We present a fully automated quantum key distribution prototype running at 625 MHz clock rate. Taking advantage of ultra low loss fibres and low-noise superconducting detectors, we can distribute 6,000 secret bits per second over 100 km and 15 bits per second over 250km

Quantum interference with photon pairs created in spatially separated sources

We report on a quantum interference experiment to probe the coherence between two photons coming from non degenerate photon pairs at telecom wavelength created in spatially separated sources. The two photons are mixed on a beam splitter and we observe a reduction of up to 84% in the coincidence count rate when the photons are made indistinguishable. This experiment constitutes an important step towards the realization of quantum teleportation and entanglement swapping with independent sources.Comment: 5 pages, 2 figures, changes according to referee's comments, discussions partly rewritte

CD27 is required for protective lytic EBV antigen-specific CD8+ T-cell expansion

Primary immunodeficiencies in the costimulatory molecule CD27 and its ligand, CD70, predispose for pathologies of uncontrolled Epstein-Barr virus (EBV) infection in nearly all affected patients. We demonstrate that both depletion of CD27+ cells and antibody blocking of CD27 interaction with CD70 cause uncontrolled EBV infection in mice with reconstituted human immune system components. While overall CD8+ T-cell expansion and composition are unaltered after antibody blocking of CD27, only some EBV-specific CD8+ T-cell responses, exemplified by early lytic EBV antigen BMLF1-specific CD8+ T cells, are inhibited in their proliferation and killing of EBV-transformed B cells. This suggests that CD27 is not required for all CD8+ T-cell expansions and cytotoxicity but is required for a subset of CD8+ T-cell responses that protect us from EBV pathology

Long distance quantum teleportation of qubits from photons at 1300 nm to photons at 1550 nm wavelength

Elementary 2-dimensional quantum states (qubits) encoded in 1300 nm wavelength photons are teleported onto 1550 nm photons. The use of telecommunication wavelengths enables to take advantage of standard optical fibre and permits to teleport from one lab to a distant one, 55 m away, connected by 2 km of fibre. A teleportation fidelity of 81.2 % is reported. This is large enough to demonstrate the principles of quantum teleportation, in particular that entanglement is exploited. This experiment constitutes a first step towards a quantum repeater.Comment: 7 pages, 5 figures, Extended version of Nature lette

CD8(+) T cells retain protective functions despite sustained inhibitory receptor expression during Epstein-Barr virus infection in vivo

Epstein Barr virus (EBV) is one of the most ubiquitous human pathogens in the world, persistently infecting more than 90% of the adult human population. It drives some of the strongest human CD8+ T cell responses, which can be observed during symptomatic primary infection known as infectious mononucleosis (IM). Despite high viral loads and prolonged CD8+ T cell stimulation during IM, EBV enters latency and is under lifelong immune control in most individuals that experience this disease. We investigated whether changes in T cell function, as frequently characterized by PD-1 up-regulation, occur during IM due to the prolonged exposure to high antigen levels. We readily detected the expansion of PD-1 positive CD8+ T cells together with high frequencies of Tim-3, 2B4, and KLRG1 expression during IM and in mice with reconstituted human immune system components (huNSG mice) that had been infected with a high dose of EBV. These PD-1 positive CD8+ T cells, however, retained proliferation, cytokine production, and cytotoxic abilities. Multiple subsets of CD8+ T cells expanded during EBV infection, including PD-1+ Tim-3+ KLRG1+ cells that express CXCR5 and TCF-1 germinal center homing and memory markers, and may also contain BATF3. Moreover, blocking the PD-1 axis compromised EBV specific immune control and resulted in virus-associated lymphomagenesis. Finally, PD-1+ , Tim-3+ , and KLRG1+ CD8+ T cell expansion coincided with declining viral loads during low dose EBV infection. These findings suggest that EBV infection primes PD-1 positive CD8+ T cell populations that rely on this receptor axis for the efficient immune control of this ubiquitous human tumor virus

Long-distance Bell-type tests using energy-time entangled photons

Long-distance Bell-type experiments are presented. The different experimental challenges and their solutions in order to maintain the strong quantum correlations between energy-time entangled photons over more than 10 km are reported and the results analyzed from the point of view of tests of fundamental physics as well as from the more applied side of quantum communication, specially quantum key distribution. Tests using more than one analyzer on each side are also presented.Comment: 22 pages including 7 figures and 5 table