136 research outputs found
Enhancement of the anomalous Hall effect and spin glass behavior in the bilayered manganite La(2-2x)Sr(1+2x)Mn2O7
The Hall resistivity and magnetization have been investigated in the
ferromagnetic state of the bilayered manganite La(2-2x)Sr(1+2x)Mn2O7 (x=0.36).
The Hall resistivity shows an increase in both the ordinary and anomalous Hall
coefficients at low temperatures below 50K, a region in which experimental
evidence for the spin glass state has been found in a low magnetic field of
1mT. The origin of the anomalous behavior of the Hall resistivity relevant to
magnetic states may lie in the intrinsic microscopic inhomogeneity in a
quasi-two-dimensional electron system.Comment: 7 pages, 4 figures, Solid State Communications (in press
Transient differential reflectivity of ferromagnetic and paramagnetic phases in the bilayered manganite La1.24Sr1.76Mn2O7
Photoinduced effects in a single crystal of bilayered manganites,
La2-2xSr1+2xMn2O7 (x=0.38), were investigated in a wide range of temperatures
by pump-probe measurement at a photon energy of 1.6eV. In a ferromagnetic
metallic state, significant enhancement of positive rise in differential
reflectivity with a slow relaxing time of hundred picoseconds was observed just
below Tc=127K, indicating that the reflectivity change with the slow relaxation
time constant is induced by laser heating. We have also observed an
unconventional fast relaxing component that has a time constant of the order of
ten picoseconds. This fast relaxing component, whose absolute value has an
asymmetric peak at Tc, is presumably due to short-range correlation of
Jahn-Teller distortion.Comment: 13 pages, 4 figures, accepted to Solid State Communication
Spin Seebeck Effect in Layered Ferromagnetic Insulators CrSiTe₃ and CrGeTe₃
We have studied the longitudinal spin Seebeck effect (LSSE) in the layered ferromagnetic insulators CrSiTe₃ and CrGeTe₃ covered by Pt films in the measurement configuration where spin current traverses the ferromagnetic Cr layers. The LSSE response is clearly observed in the ferromagnetic phase and—in contrast to a standard LSSE magnet Y₃Fe₅O₁₂—persists above the critical temper- atures in both CrSiTe₃/Pt and CrGeTe₃/Pt samples. With the help of a numerical calculation, we attribute the LSSE signals observed in the paramagnetic regime to exchange-dominated interlayer transport of in-plane paramagnetic moments reinforced by short-range ferromagnetic correlations and strong Zeeman effects
Majorana quantization and half-integer thermal quantum Hall effect in a Kitaev spin liquid
The quantum Hall effect (QHE) in two-dimensional (2D) electron gases, which
is one of the most striking phenomena in condensed matter physics, involves the
topologically protected dissipationless charge current flow along the edges of
the sample. Integer or fractional electrical conductance are measured in units
of , which is associated with edge currents of electrons or
quasiparticles with fractional charges, respectively. Here we discover a novel
type of quantization of the Hall effect in an insulating 2D quantum magnet. In
-RuCl with dominant Kitaev interaction on 2D honeycomb lattice, the
application of a parallel magnetic field destroys the long-range magnetic
order, leading to a field-induced quantum spin liquid (QSL) ground state with
massive entanglement of local spins. In the low-temperature regime of the QSL
state, we report that the 2D thermal Hall conductance
reaches a quantum plateau as a function of applied magnetic field.
attains a quantization value of ,
which is exactly half of in the integer QHE. This
half-integer thermal Hall conductance observed in a bulk material is a direct
signature of topologically protected chiral edge currents of charge neutral
Majorana fermions, particles that are their own antiparticles, which possess
half degrees of freedom of conventional fermions. These signatures demonstrate
the fractionalization of spins into itinerant Majorana fermions and
fluxes predicted in a Kitaev QSL. Above a critical magnetic field, the
quantization disappears and goes to zero rapidly,
indicating a topological quantum phase transition between the states with and
without chiral Majorana edge modes. Emergent Majorana fermions in a quantum
magnet are expected to have a major impact on strongly correlated topological
quantum matter.Comment: 7 pages, 8 figures. Submitted versio
Unusual development of light-reflecting pigment cells in intact and regenerating tail in the periodic albino mutant of Xenopus laevis
Unusual light-reflecting pigment cells, “white pigment cells”, specifically appear in the periodic albino mutant (ap/ap) of Xenopus laevis and localize in the same place where melanophores normally differentiate in the wild-type. The mechanism responsible for the development of unusual pigment cells is unclear. In this study, white pigment cells in the periodic albino were compared with melanophores in the wild-type, using a cell culture system and a tail-regenerating system. Observations of both intact and cultured cells demonstrate that white pigment cells are unique in (1) showing characteristics of melanophore precursors at various stages of development, (2) accumulating reflecting platelets characteristic of iridophores, and (3) exhibiting pigment dispersion in response to α-melanocyte stimulating hormone (α-MSH) in the same way that melanophores do. When a tadpole tail is amputated, a functionally competent new tail is regenerated. White pigment cells appear in the mutant regenerating tail, whereas melanophores differentiate in the wild-type regenerating tail. White pigment cells in the mutant regenerating tail are essentially similar to melanophores in the wild-type regenerating tail with respect to their localization, number, and response to α-MSH. In addition to white pigment cells, iridophores which are never present in the intact tadpole tail appear specifically in the somites near the amputation level in the mutant regenerating tail. Iridophores are distinct from white pigment cells in size, shape, blue light-induced fluorescence, and response to α-MSH. These findings strongly suggest that white pigment cells in the mutant arise from melanophore precursors and accumulate reflecting platelets characteristic of iridophores
In Vitro Dedifferentiation of Melanocytes from Adult Epidermis
In previous work we described a novel culture technique using a cholera toxin and PMA-free medium (Mel-mix) for obtaining pure melanocyte cultures from human adult epidermis. In Mel-mix medium the cultured melanocytes are bipolar, unpigmented and highly proliferative. Further characterization of the cultured melanocytes revealed the disappearance of c-Kit and TRP-1 and induction of nestin expression, indicating that melanocytes dedifferentiated in this in vitro culture. Cholera toxin and PMA were able to induce c-Kit and TRP-1 protein expressions in the cells, reversing dedifferentiation. TRP-1 mRNA expression was induced in dedifferentiated melanocytes by UV-B irradiated keratinocyte supernatants, however direct UV-B irradiation of the cells resulted in further decrease of TRP-1 mRNA expression. These dedifferentiated, easily accessible cultured melanocytes provide a good model for studying melanocyte differentiation and possibly transdifferentiation. Because melanocytes in Mel-mix medium can be cultured with human serum as the only supplement, this culture system is also suitable for autologous cell transplantation
Multiple Roles of Integrin-Linked Kinase in Epidermal Development, Maturation and Pigmentation Revealed by Molecular Profiling
Integrin-linked kinase (ILK) is an important scaffold protein that mediates a variety of cellular responses to integrin stimulation by extracellular matrix proteins. Mice with epidermis-restricted inactivation of the Ilk gene exhibit pleiotropic phenotypic defects, including impaired hair follicle morphogenesis, reduced epidermal adhesion to the basement membrane, compromised epidermal integrity, as well as wasting and failure to thrive leading to perinatal death. To better understand the underlying molecular mechanisms that cause such a broad range of alterations, we investigated the impact of Ilk gene inactivation on the epidermis transcriptome. Microarray analysis showed over 700 differentially regulated mRNAs encoding proteins involved in multiple aspects of epidermal function, including keratinocyte differentiation and barrier formation, inflammation, regeneration after injury, and fundamental epidermal developmental pathways. These studies also revealed potential effects on genes not previously implicated in ILK functions, including those important for melanocyte and melanoblast development and function, regulation of cytoskeletal dynamics, and homeobox genes. This study shows that ILK is a critical regulator of multiple aspects of epidermal function and homeostasis, and reveals the previously unreported involvement of ILK not only in epidermal differentiation and barrier formation, but also in melanocyte genesis and function
Delayed Cutaneous Wound Healing and Aberrant Expression of Hair Follicle Stem Cell Markers in Mice Selectively Lacking Ctip2 in Epidermis
This is the publisher’s final pdf. The published article is copyrighted by PLoS and can be found at: http://www.plosone.org/home.action.Background: COUP-TF interacting protein 2 [(Ctip2), also known as Bcl11b] is an important regulator of skin homeostasis, and is overexpressed in head and neck cancer. Ctip2(ep-/-) mice, selectively ablated for Ctip2 in epidermal keratinocytes, exhibited impaired terminal differentiation and delayed epidermal permeability barrier (EPB) establishment during development, similar to what was observed in Ctip2 null (Ctip2(-/-)) mice. Considering that as an important role of Ctip2, and the fact that molecular networks which underlie cancer progression partially overlap with those responsible for tissue remodeling, we sought to determine the role of Ctip2 during cutaneous wound healing. \ud
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Methodology/Principal Findings: Full thickness excisional wound healing experiments were performed on Ctip2(L2/L2) and Ctip2(ep-/-) animals per time point and used for harvesting samples for histology, immunohistochemistry (IHC) and immunoblotting. Results demonstrated inherent defects in proliferation and migration of Ctip2 lacking keratinocytes during re-epithelialization. Mutant mice exhibited reduced epidermal proliferation, delayed keratinocyte activation, altered cell-cell adhesion and impaired ECM development. Post wounding, Ctip2(ep-/-) mice wounds displayed lack of E-Cadherin suppression in the migratory tongue, insufficient expression of alpha smooth muscle actin (alpha SMA) in the dermis, and robust induction of K8. Importantly, dysregulated expression of several hair follicle (HF) stem cell markers such as K15, NFATc1, CD133, CD34 and Lrig1 was observed in mutant skin during wound repair. \ud
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Conclusions/Significance: Results confirm a cell autonomous role of keratinocytic Ctip2 to modulate cell migration, proliferation and/or differentiation, and to maintain HF stem cells during cutaneous wounding. Furthermore, Ctip2 in a non-cell autonomous manner regulated granulation tissue formation and tissue contraction during wound closure
A molecular systems approach to modelling human skin pigmentation: identifying underlying pathways and critical components
The C:N:P:S stoichiometry of soil organic matter
The formation and turnover of soil organic matter (SOM) includes the biogeochemical processing of the macronutrient elements nitrogen (N), phosphorus (P) and sulphur (S), which alters their stoichiometric relationships to carbon (C) and to each other. We sought patterns among soil organic C, N, P and S in data for c. 2000 globally distributed soil samples, covering all soil horizons. For non-peat soils, strong negative correlations (p < 0.001) were found between N:C, P:C and S:C ratios and % organic carbon (OC), showing that SOM of soils with low OC concentrations (high in mineral matter) is rich in N, P and S. The results can be described approximately with a simple mixing model in which nutrient-poor SOM (NPSOM) has N:C, P:C and S:C ratios of 0.039, 0.0011 and 0.0054, while nutrient-rich SOM (NRSOM) has corresponding ratios of 0.12, 0.016 and 0.016, so that P is especially enriched in NRSOM compared to NPSOM. The trends hold across a range of ecosystems, for topsoils, including O horizons, and subsoils, and across different soil classes. The major exception is that tropical soils tend to have low P:C ratios especially at low N:C. We suggest that NRSOM comprises compounds selected by their strong adsorption to mineral matter. The stoichiometric patterns established here offer a new quantitative framework for SOM classification and characterisation, and provide important constraints to dynamic soil and ecosystem models of carbon turnover and nutrient dynamics
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