962 research outputs found
Diffuse-interface model for rapid phase transformations in nonequilibrium systems
A thermodynamic approach to rapid phase transformations within a diffuse
interface in a binary system is developed. Assuming an extended set of
independent thermodynamic variables formed by the union of the classic set of
slow variables and the space of fast variables, we introduce finiteness of the
heat and solute diffusive propagation at the finite speed of the interface
advancing. To describe the transformation within the diffuse interface, we use
the phase-field model which allows us to follow the steep but smooth change of
phases within the width of diffuse interface. The governing equations of the
phase-field model are derived for the hyperbolic model, model with memory, and
for a model of nonlinear evolution of transformation within the
diffuse-interface. The consistency of the model is proved by the condition of
positive entropy production and by the outcomes of the fluctuation-dissipation
theorem. A comparison with the existing sharp-interface and diffuse-interface
versions of the model is given.Comment: 15 pages, regular article submitted to Physical Review
Knudsen Effect in a Nonequilibrium Gas
From the molecular dynamics simulation of a system of hard-core disks in
which an equilibrium cell is connected with a nonequilibrium cell, it is
confirmed that the pressure difference between two cells depends on the
direction of the heat flux. From the boundary layer analysis, the velocity
distribution function in the boundary layer is obtained. The agreement between
the theoretical result and the numerical result is fairly good.Comment: 4pages, 4figure
Frequent allelic deletion at the FHIT locus associated with p53 overexpression in squamous cell carcinoma subtype of Taiwanese non-small-cell lung cancers
[[abstract]]The fragile histidine triad (FHIT) gene, encompassing the FRA3B fragile site at chromosome 3p14.2, is a tumour suppressor gene involved in different tumour types including non-small-cell lung cancers (NSCLCs). In the current study, we examined for allelic deletion at the FHIT locus in 58 primary and microdissected NSCLCs, for which a clinicopathologic profile was available. We found a loss of 87.7% in heterozygosity (LOH) frequency at one or more microsatellite markers (D3S1289, D3S2408, D3S1766, D3S1312, D3S1600). Allelic deletion of D3S1766 was related to tumour histology in 10 of 11 squamous cell carcinomas (90.9%) displaying LOH compared with nine of 17 adenocarcinomas (52.9%; P = 0.049). Besides, in the subset of adenocarcinomas, a higher rate of LOH at D3S1289 was observed in male ( six out of eight, 75%) than in female patients (four out of 17, 23.5%; P = 0.028). However, FHIT LOH was not correlated overall with a variety of clinical parameters including sex, smoking status, staging, lymph node metastasis and survival. These results indicated that the high frequency of FHIT gene disruption was important in the development of both squamous cell carcinomas and adenocarcinomas. Furthermore, there was no association between LOH at FHIT and protein expression, suggesting the presence of complex mechanisms of Fhit inactivation. On the other hand, the association between FHIT LOH and p53 protein overexpression assessment reached statistical significance ( P = 0.026), implying that common alterations affect the two genes in tumour progression
Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein
In a screen for proteins that interact with Jak2, we identified a previously uncharacterized 70-kDa protein and cloned the corresponding cDNA. The predicated sequence indicates that p70 contains an SH3 domain and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. p70 transcripts were found in all tissues examined. Similarly, when an antibody raised against a C-terminal peptide to analyze p70 protein expression was used, all murine tissues examined were found to express p70. To investigate the in vivo role of p70, we generated a p70-deficient mouse strain. Mice lacking p70 are viable, develop normally, and do not display any obvious abnormalities. No differences were detected in various hematological parameters, including bone marrow colony-forming ability, in response to cytokines that utilize Jak2. In addition, no impairment in B- and T-cell development and proliferative ability was detected
Pumping Speed Measurement and Analysis for the Turbo Booster Pump
This study applies testing apparatus and a computational approach to examine a newly designed spiral-grooved turbo booster pump (TBP), which has both volume type and momentum transfer type vacuum pump functions, and is capable
of operating at optimum discharge under pressures from approximately 1000 Pa to a high vacuum. Transitional flow pumping speed is increased by a well-designed connecting
element. Pumping performance is predicted and examined via two computational approaches, namely the computational fluid dynamics (CFD) method and the direct simulation Monte Carlo (DSMC) method. In CFD analysis, comparisons of measured and calculated inlet pressure in the slip and continuum flow demonstrate the accuracy of the
calculation. Meanwhile, in transition flow, the continuum model of CFD is unsuitable for calculating such rarefied gas. The pumping characteristics for a full 3D model on a rotating frame in transition and molecular regimes thus are simulated using the DSMC method and then confirmed experimentally. However, when the Knudsen number is in the
range 0.5 < Kn < 0.1, neither CFD computation nor DSMC simulation is suitable for analyzing the pumping speed of the turbo booster pump. In this situation, the experimental
approach is the most appropriate and effective method for analyzing pumping speed. Moreover, the developed pump is tested using assessment systems constructed according to ISO and JVIS-005 standards, respectively. Comparisons are also made with other turbo pumps. The compared results show that the turbo booster pump presented here has good
foreline performance
Some analytical models of radiating collapsing spheres
We present some analytical solutions to the Einstein equations, describing
radiating collapsing spheres in the diffusion approximation. Solutions allow
for modeling physical reasonable situations. The temperature is calculated for
each solution, using a hyperbolic transport equation, which permits to exhibit
the influence of relaxational effects on the dynamics of the system.Comment: 17 pages Late
Steady State Thermodynamics of Langevin Systems
We study Langevin dynamics describing nonequilibirum steady states. Employing
the phenomenological framework of steady state thermodynamics constructed by
Oono and Paniconi [Prog. Theor. Phys. Suppl. {\bf130}, 29 (1998)], we find that
the extended form of the second law which they proposed holds for transitions
between steady states and that the Shannon entropy difference is related to the
excess heat produced in an infinitely slow operation. A generalized version of
the Jarzynski work relation plays an important role in our theory.Comment: 4 page
Magnetoresistance of a two-dimensional electron gas with spatially periodic lateral modulations: Exact consequences of Boltzmann's equation
On the basis of Boltzmann's equation, and including anisotropic scattering in
the collision operator, we investigate the effect of one-dimensional
superlattices on two-dimensional electron systems. In addition to superlattices
defined by static electric and magnetic fields, we consider mobility
superlattices describing a spatially modulated density of scattering centers.
We prove that magnetic and electric superlattices in -direction affect only
the resistivity component if the mobility is homogeneous, whereas a
mobility lattice in -direction in the absence of electric and magnetic
modulations affects only . Solving Boltzmann's equation numerically,
we calculate the positive magnetoresistance in weak magnetic fields and the
Weiss oscillations in stronger fields within a unified approach.Comment: submitted to PR
EUV spectra of highly-charged ions W-W relevant to ITER diagnostics
We report the first measurements and detailed analysis of extreme ultraviolet
(EUV) spectra (4 nm to 20 nm) of highly-charged tungsten ions W to
W obtained with an electron beam ion trap (EBIT). Collisional-radiative
modelling is used to identify strong electric-dipole and magnetic-dipole
transitions in all ionization stages. These lines can be used for impurity
transport studies and temperature diagnostics in fusion reactors, such as ITER.
Identifications of prominent lines from several W ions were confirmed by
measurement of isoelectronic EUV spectra of Hf, Ta, and Au. We also discuss the
importance of charge exchange recombination for correct description of
ionization balance in the EBIT plasma.Comment: 11 pages, 4 figure
Time-delayed spread of viruses in growing plaques
The spread of viruses in growing plaques predicted by classical models is greater than that measured experimentally. There is a widespread belief that this discrepancy is due to biological factors. Here we show that the observed speeds can be satisfactorily predicted by a purely physical model that takes into account the delay time due to virus reproduction inside infected cells. No free or adjustable parameters are used
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