Tracking transplanted bone marrow stem cells and their effects in the rat MCAO stroke model.

In this study, rat bone marrow stromal stem cells (BMSCs) were tracked after IV administration to rats with experimental stroke caused by middle cerebral artery occlusion (MCAO). In addition, the effects of BMSC treatment on blood cell composition, brain glia and sensorimotor behavior was studied and compared to that which occurred spontaneously during the normal recovery process after stroke. We found that the vast majority of radiolabeled or fluorescently labeled BMSCs traveled to and remained in peripheral organs (lungs, spleen, liver) 3 days after IV injection in the MCAO rat. Once in the circulation, BMSCs also produced rapid alterations in host blood cell composition, increasing both neutrophil and total white blood cell count by 6 hours post-injection. In contrast, few injected BMSCs traveled to the brain and almost none endured there long term. Nonetheless, BMSC treatment produced dramatic changes in the number and activation of brain astroglia and microglia, particularly in the region of the infarct. These cellular changes were correlated with a marked improvement in performance on tests of sensory and motor function as compared to the partial recovery of function seen in PBS-injected control rats. We conclude that the notable recovery in function observed after systemic administration of BMSCs to MCAO rats is likely due to the cellular changes in blood and/or brain cell number, activation state and their cytokine/growth factor products

3D thumbnails for mobile media browser interface with autostereoscopic displays

In this paper, we focus on the problem of how to visualize and browse 3D videos and 3D images in a media browser application, running on a 3D-enabled mobile device with an autostereoscopic display. We propose a 3D thumbnail representation format and an algorithm for automatic 3D thumbnail generation from a 3D video + depth content. Then, we present different 3D user interface layout schemes for 3D thumbnails, and discuss these layouts with the focus on their usability and ergonomics. © 2010 Springer-Verlag Berlin Heidelberg

3D thumbnails for 3D videos with depth

In this chapter, we present a new thumbnail format for 3D videos with depth, 3D thumbnail, which helps users to understand the content by preserving the recognizable features and qualities of 3D videos. The current thumbnail solutions do not give the general idea of the content and are not illustrative. In spite of the existence of 3D media content databases, there is no thumbnail representation for 3D contents. Thus, we propose a framework that generates 3D thumbnails from layered depth video (LDV) and video plus depth (V+D) by using two different methodologies on importance maps: Saliency-depth and layer based approaches. Finally, several experiments are presented that indicate 3D thumbnails are illustrative. © 2012, IGI Global

Identifying the drivers of circular food packaging: a comprehensive review for the current state of the food supply chain to be sustainable and circular

The resilience of food systems is jeopardized by using food packaging materials that have adverse impacts on the environment, food quality, food safety, shelf-life, food loss, and waste. Therefore, a transition into a more sustainable system can only be possible by adopting circular economy principles and practices that can facilitate the elimination of unsustainable packaging, irresponsible disposal behaviors, and waste management. This paper mainly focuses on circular packaging practices in the existing literature to reveal the drivers of circular food packaging applications. The study also displays the triple combinations of material-sector, material-CE, and sector-CE principles. As a methodology, a systematic literature review (SLR) has been used for this study. Furthermore, this study investigates the literature findings, such as the most frequently mentioned food sector and sub-sector, CE principles, materials adopted for food packaging, and so on. The primary contribution of this study to the body of literature is the synthesis and mapping of the literature as a whole from the perspectives of CE principles, both sector-based and national, and the materials used through circular food packaging, and the attempt to facilitate this transition into a more circular system by outlining the drivers of circular food packaging

Assessing the Impact of COVID-19 on Sustainable Food Supply Chains

Recently, it has become an important issue to ensure sustainability, especially in food supply chains, against the rapidly growing population, increasing demand, and sudden disruptions caused by uncertain times such as that caused by COVID-19. Since food supply chains has vulnerable products and processes, it is critical to understand the sustainability factors of food supply chains especially in uncertain times such during the COVID-19 pandemic. This study aims to determine sustainability factors of food supply chains. An Interpretive Structural Modelling method is used to state the relations between sustainability factors of food supply chains. As a result of the study, Information Sharing and Managerial Approaches are classified as driving factors; Food Safety and Security, Know-How Transfer, Logistics Networking, Risk Mitigation, Employee Commitment, Innovation, Traceability and Responsiveness are categorized as linkage factors. This article will be beneficial for managers in helping them develop sustainable food supply chains during uncertain times by focusing on traceability, information sharing, know-how transfer, food safety and security

Design specification, commission and calibration of the University of Strathclyde's Fully Turbulent Flow Channel (FTFC) facility

Measurements in the Fully Turbulent Flow Channel (FTFC) are presented for Reynolds number up to 3.3∙10^5, based on the mean bulk velocity and the channel height. The FTFC is a new experimental facility recently installed at the Department of Naval Architecture, Ocean and Marine Engineering of the University of Strathclyde. It is a high aspect ratio flow channel with a three-meter-long testing section, designed for the indirect measurement of the drag caused by surface characteristics. The main advantage of this channel is that the measurements of the pressure drop along the test section can be combined with laser-based boundary layer measurement techniques such as LDA, PIV, etc. The present work focuses on the design features and the calibration of the new experimental facility, with hydraulically smooth control panels produced on purpose. The interest in these data originates from the fact that channel flow serves as a reference flow for varying special surface structures, such as fouling control coatings, as well as some drag reduction mechanisms such as riblets, dimples, tubercles, in the presence of some biofouling types

blaKPC and rmtB on a single plasmid in Enterobacter amnigenus and Klebsiella pneumoniae isolates from the same patient

Enterobacter amnigenus (EA76) and Klebsiella pneumoniae (KP76) isolates with multidrug-resistant (MDR) patterns were identified from the same patient in the neurosurgery department of our hospital. An outbreak of MDR K. pneumoniae had also occurred in this department. To characterize the resistance mechanism and molecular epidemiology of these isolates, sequential experiments including antimicrobial susceptibility testing, polymerase chain reaction (PCR), plasmid analysis, pulsed field gel electrophoresis (PFGE), and multilocus sequence typing (MLST) were performed. EA76 and KP76 were resistant to all of the antibiotics tested, except colistin and tigecycline. blaKPC-2, blaTEM-1, blaSHV-12, blaCTX-M-3, blaCTX-M-14, and rmtB genes were identified in both isolates, with blaKPC-2, blaTEM-1, blaCTX-M-14, and rmtB being co-carried on one plasmid in each isolate. Further analysis showed different restriction patterns between the two KPC-carrying plasmids. Of the 11 carbapenem-resistant isolates found in the outbreak, all were resistant to all of the β-lactams tested, with 63.64% (7/11) also exhibiting resistance to aminoglycosides and 72.73% (8/11) exhibiting resistance to quinolones. PCR analysis and molecular typing of the 11 K. pneumoniae strains revealed that the seven aminoglycoside-resistant isolates shared the same antibiotic-resistant gene pattern and identical or one-band-difference PFGE profiles relative to KP76. In addition, all of the eight aminoglycoside-resistant isolates, including KP76, belonged to the national epidemic clone ST11. The overall results indicate the emergence of E. amnigenus and outbreak of ST11 K. pneumoniae, with both co-harboring blaKPC and rmtB genes on a single plasmid in our neurosurgery wards

L1CAM mutation in association with X-linked hydrocephalus and Hirschsprung’s disease

X-linked hydrocephalus (XLH) is characterized by increased intracranial ventricle size and head circumference secondary to aqueduct of Sylvius congenital stenosis. Exceedingly rare is the concurrence of XLH and Hirschsprung’s disease (HSCR) with a theoretical incidence of 1 in 125–250 million cases. Herein, we are describing a case of a patient with concurrent XLH and HSCR. The patient was delivered via cesarean section at 37 weeks gestation and underwent uneventful ventriculoperitoneal shunt placement. As a part of a workup for constipation, we performed a rectal biopsy, which was consistent with HSCR. Genetics testing showed hemizygous for R558X hemizygous mutation in the L1CAM gene. A C → T nucleotide substitution in exon 13 resulted in replacement of an arginine codon with a stop codon, a nonsense mutation. Although it is widely accepted that HSCR represents the failure of early embryonic neural crest cells to migrate properly, the exact mechanism is not known. The association of HSCR with XLH in the presence of L1CAM mutations remains quite interesting because cell adhesion molecules are involved in the proper migration of neural components throughout the body. Additional studies are necessary to fully elucidate the relationship between XLH and HSCR in the presence of L1CAM mutations