Surface-wave interferometry on single subwavelength slit-groove structures fabricated on gold films

We apply the technique of far-field interferometry to measure the properties of surface waves generated by two-dimensional (2D) single subwavelength slit-groove structures on gold films. The effective surface index of refraction measured for the surface wave propagating over a distance of more than 12 microns is determined to be 1.016 with a measurement uncertainty of 0.004, to within experimental uncertainty of the expected bound surface plasmon-polariton (SPP) value for a Au/Air interface of 1.018. We compare these measurements to finite-difference-time-domain (FDTD) numerical simulations of the optical field transmission through these devices. We find excellent agreement between the measurements and the simulations for the surface index of refraction. The measurements also show that the surface wave propagation parameter exhibits transient behavior close to the slit, evolving smoothly from greater values asymptotically toward the value expected for the SPP over the first 2-3 microns of slit-groove distance. This behavior is confirmed by the FDTD simulations

Unitary representations of the W3-algebra with c ≥ 2

We prove unitarity of the vacuum representation of the W_3-algebra for all values of the central charge c ≥ 2.We do it by modifying the free field realization of Fateev and Zamolodchikov resulting in a representation which, by a nontrivial argument, can be shown to be unitary on a certain invariant subspace, although it is not unitary on the full space of the two currents needed for the construction. These vacuum representations give rise to simple unitary vertex operator algebras. We also construct explicitly unitary representations for many positive lowest weight values. Taking into account the known form of the Kac determinants, we then completely clarify the question of unitarity of the irreducible lowest weight representations of the W_3-algebra in the 2 ≤ c ≤ 98 region

Formation of fundamental structures in Bose-Einstein Condensates

The meanfield interaction in a Bose condensate provides a nonlinearity which can allow stable structures to exist in the meanfield wavefunction. We discuss a number of examples where condensates, modelled by the one dimensional Gross Pitaevskii equation, can produce gray solitons and we consider in detail the case of two identical condensates colliding in a harmonic trap. Solitons are shown to form from dark interference fringes when the soliton structure, constrained in a defined manner, has lower energy than the interference fringe and an analytic expression is given for this condition.Comment: 7 pages, 3 figures, requires ioplppt.st

The cuttlefish Sepia officinalis (Sepiidae, Cephalopoda) constructs cuttlebone from a liquid-crystal precursor

Cuttlebone, the sophisticated buoyancy device of cuttlefish, is made of extensive superposed chambers that have a complex internal arrangement of calcified pillars and organic membranes. It has not been clear how this structure is assembled. We find that the membranes result from a myriad of minor membranes initially filling the whole chamber, made of nanofibres evenly oriented within each membrane and slightly rotated with respect to those of adjacent membranes, producing a helical arrangement. We propose that the organism secretes a chitin-protein complex, which self-organizes layer-by-layer as a cholesteric liquid crystal, whereas the pillars are made by viscous fingering. The liquid crystallization mechanism permits us to homologize the elements of the cuttlebone with those of other coleoids and with the nacreous septa and the shells of nautiloids. These results challenge our view of this ultra-light natural material possessing desirable mechanical, structural and biological properties, suggesting that two self-organizing physical principles suffice to understand its formation.Spanish Ministerio de Ciencia e Innovacion [CGL2010-20748-CO2-01, CGL2013-48247-P, FIS2013-48444-C2-2-P]; Andalusian Consejeria de Innovacion Ciencia y Tecnologia [RNM6433]; (Sepiatech, PROMAR program) of the Portuguese Ministerio da Agricultura e do Mar, Portugal [31.03.05.FEP.002]; Junta de Andalucia [RNM363]; FP7 COST Action of the European Community. [TD0903]info:eu-repo/semantics/publishedVersio

Fluctuations of the Initial Conditions and the Continuous Emission in Hydrodynamic Description of Two-Pion Interferometry

Within hydrodynamic approach, we study the Bose-Einstein correlation of identical pions by taking into account both event-by-event fluctuating initial conditions and continuous pion emission during the whole development of the hot and dense matter formed in high-energy collisions. Considerable deviations occur, compared to the usual hydro calculations with smooth initial conditions and a sudden freeze-out on a well defined hypersurface. Comparison with data at RHIC shows that, despite rather rough approximation we used here, this description can give account of the $m_T$ dependence of $R_L$ and $R_s$ and improves considerably the one for $R_o$ with respect to the usual version.Comment: 5 pages, 4 figure

Patronin-mediated minus end growth is required for dendritic microtubule polarity.

Microtubule minus ends are thought to be stable in cells. Surprisingly, in Drosophila and zebrafish neurons, we observed persistent minus end growth, with runs lasting over 10 min. In Drosophila, extended minus end growth depended on Patronin, and Patronin reduction disrupted dendritic minus-end-out polarity. In fly dendrites, microtubule nucleation sites localize at dendrite branch points. Therefore, we hypothesized minus end growth might be particularly important beyond branch points. Distal dendrites have mixed polarity, and reduction of Patronin lowered the number of minus-end-out microtubules. More strikingly, extra Patronin made terminal dendrites almost completely minus-end-out, indicating low Patronin normally limits minus-end-out microtubules. To determine whether minus end growth populated new dendrites with microtubules, we analyzed dendrite development and regeneration. Minus ends extended into growing dendrites in the presence of Patronin. In sum, our data suggest that Patronin facilitates sustained microtubule minus end growth, which is critical for populating dendrites with minus-end-out microtubules

Oral tolerance to cancer can be abrogated by T regulatory cell inhibition

Oral administration of tumour cells induces an immune hypo-responsiveness known as oral tolerance. We have previously shown that oral tolerance to a cancer is tumour antigen specific, non-cross-reactive and confers a tumour growth advantage. We investigated the utilisation of regulatory T cell (Treg) depletion on oral tolerance to a cancer and its ability to control tumour growth. Balb/C mice were gavage fed homogenised tumour tissue – JBS fibrosarcoma (to induce oral tolerance to a cancer), or PBS as control. Growth of subcutaneous JBS tumours were measured; splenic tissue excised and flow cytometry used to quantify and compare systemic Tregs and T effector (Teff) cell populations. Prior to and/or following tumour feeding, mice were intraperitoneally administered anti-CD25, to inactivate systemic Tregs, or given isotype antibody as a control. Mice which were orally tolerised prior to subcutaneous tumour induction, displayed significantly higher systemic Treg levels (14% vs 6%) and faster tumour growth rates than controls (p<0.05). Complete regression of tumours were only seen after Treg inactivation and occurred in all groups - this was not inhibited by tumour feeding. The cure rates for Treg inactivation were 60% during tolerisation, 75% during tumour growth and 100% during inactivation for both tolerisation and tumour growth. Depletion of Tregs gave rise to an increased number of Teff cells. Treg depletion post-tolerisation and post-tumour induction led to the complete regression of all tumours on tumour bearing mice. Oral administration of tumour tissue, confers a tumour growth advantage and is accompanied by an increase in systemic Treg levels. The administration of anti-CD25 Ab decreased Treg numbers and caused an increase in Teffs. Most notably Treg cell inhibition overcame established oral tolerance with consequent tumor regression, especially relevant to foregut cancers where oral tolerance is likely to be induced by the shedding of tumour tissue into the gut

Pion Interferometry for Hydrodynamical Expanding Source with a Finite Baryon Density

We calculate the two-pion correlation function for an expanding hadron source with a finite baryon density. The space-time evolution of the source is described by relativistic hydrodynamics and the Hanbury-Brown-Twiss (HBT) radius is extracted after effects of collective expansion and multiple scattering on the HBT interferometry have been taken into account, using quantum probability amplitudes in a path-integral formalism. We find that this radius is substantially smaller than the HBT radius extracted from the freeze-out configuration.Comment: 4 pages, 2 figure