82 research outputs found
Developing Cloud Chambers with High School Students
The result and outcome of the \textit{cloud chamber project}, which aims to
develop a cloud chamber useful for science education is reported in detail. A
project includes both three high school students and a teacher as a part of
Super Science High School (SSH) program in our school. We develop a
dry-ice-free cloud chamber using salt and ice (or snow). Technical details of
the chamber are described. We also argue how the project have affected
student's cognition, motivation, academic skills and behavior. The research
project has taken steps of professional researchers, i.e., in planning
research, applying fund, writing a paper and giving a talk in conferences. From
interviews with students, we have learnt that such style of scientific activity
is very effective in promoting student's motivation for learning science.Comment: 9 pages, accepted to the proceedings of APPC12 - the 12th Asia
Pacific Physics Conferenc
Orbital-Free Density Functional Theory: Kinetic Potentials and Ab-Initio Local Pseudopotentials
In the density functional (DF) theory of Kohn and Sham, the kinetic energy of
the ground state of a system of noninteracting electrons in a general external
field is calculated using a set of orbitals. Orbital free methods attempt to
calculate this directly from the electron density by approximating the
universal but unknown kinetic energy density functional. However simple local
approximations are inaccurate and it has proved very difficult to devise
generally accurate nonlocal approximations. We focus instead on the kinetic
potential, the functional derivative of the kinetic energy DF, which appears in
the Euler equation for the electron density. We argue that the kinetic
potential is more local and more amenable to simple physically motivated
approximations in many relevant cases, and describe two pathways by which the
value of the kinetic energy can be efficiently calculated. We propose two
nonlocal orbital free kinetic potentials that reduce to known exact forms for
both slowly varying and rapidly varying perturbations and also reproduce exact
results for the linear response of the density of the homogeneous system to
small perturbations. A simple and systematic approach for generating accurate
and weak ab-initio local pseudopotentials which produce a smooth slowly varying
valence component of the electron density is proposed for use in orbital free
DF calculations of molecules and solids. The use of these local
pseudopotentials further minimizes the possible errors from the kinetic
potentials. Our theory yields results for the total energies and ionization
energies of atoms, and for the shell structure in the atomic radial density
profiles that are in very good agreement with calculations using the full
Kohn-Sham theory.Comment: To be published in Phys. Rev.
Impact of ultrasound guidance in central venous catheterization by inexperienced trainees: a prospective observational study
Gradient corrections for semiclassical theories of atoms in strong magnetic fields
This paper is divided into two parts. In the first one the von Weizs\"acker
term is introduced to the Magnetic TF theory and the resulting MTFW functional
is mathematically analyzed. In particular, it is shown that the von
Weizs\"acker term produces the Scott correction up to magnetic fields of order
, in accordance with a result of V. Ivrii on the quantum mechanical
ground state energy. The second part is dedicated to gradient corrections for
semiclassical theories of atoms restricted to electrons in the lowest Landau
band. We consider modifications of the Thomas-Fermi theory for strong magnetic
fields (STF), i.e. for . The main modification consists in replacing
the integration over the variables perpendicular to the field by an expansion
in angular momentum eigenfunctions in the lowest Landau band. This leads to a
functional (DSTF) depending on a sequence of one-dimensional densities. For a
one-dimensional Fermi gas the analogue of a Weizs\"acker correction has a
negative sign and we discuss the corresponding modification of the DSTF
functional.Comment: Latex2e, 36 page
Interacting fermions and N=2 Chern-Simons-matter theories
The partition function on the three-sphere of N=3 Chern-Simons-matter
theories can be formulated in terms of an ideal Fermi gas. In this paper we
show that, in theories with N=2 supersymmetry, the partition function
corresponds to a gas of interacting fermions in one dimension. The large N
limit is the thermodynamic limit of the gas and it can be analyzed with the
Hartree and Thomas-Fermi approximations, which lead to the known large N
solutions of these models. We use this interacting fermion picture to analyze
in detail N=2 theories with one single node. In the case of theories with no
long-range forces we incorporate exchange effects and argue that the partition
function is given by an Airy function, as in N=3 theories. For the theory with
g adjoint superfields and long-range forces, the Thomas-Fermi approximation
leads to an integral equation which determines the large N, strongly coupled
R-charge.Comment: 29 pages, 4 figure
Identification of embryonic stem cell-derived midbrain dopaminergic neurons for engraftment
Embryonic stem cells (ESCs) represent a promising source of midbrain dopaminergic (DA) neurons for applications in Parkinson disease. However, ESC-based transplantation paradigms carry a risk of introducing inappropriate or tumorigenic cells. Cell purification before transplantation may alleviate these concerns and enable identification of the specific DA neuron stage most suitable for cell therapy. Here, we used 3 transgenic mouse ESC reporter lines to mark DA neurons at 3 stages of differentiation (early, middle, and late) following induction of differentiation using Hes5::GFP, Nurr1::GFP, and Pitx3::YFP transgenes, respectively. Transplantation of FACS-purified cells from each line resulted in DA neuron engraftment, with the mid-stage and late-stage neuron grafts being composed almost exclusively of midbrain DA neurons. Mid-stage neuron cell grafts had the greatest amount of DA neuron survival and robustly induced recovery of motor deficits in hemiparkinsonian mice. Our data suggest that the Nurrl(+) stage (middle stage) of neuronal differentiation is particularly suitable for grafting ESC-derived DA neurons. Moreover, global transcriptome analysis of progeny from each of the ESC reporter lines revealed expression of known midbrain DA neuron genes and also uncovered previously uncharacterized midbrain genes. These data demonstrate remarkable fate specificity of ESC-derived DA neurons and outline a sequential stage-specific ESC reporter line paradigm for in vivo gene discovery
The Ground States of Large Quantum Dots in Magnetic Fields
The quantum mechanical ground state of a 2D -electron system in a
confining potential ( is a coupling constant) and a homogeneous
magnetic field is studied in the high density limit , with fixed. It is proved that the ground state energy and
electronic density can be computed {\it exactly} in this limit by minimizing
simple functionals of the density. There are three such functionals depending
on the way varies as : A 2D Thomas-Fermi (TF) theory applies
in the case ; if the correct limit theory
is a modified -dependent TF model, and the case is described
by a ``classical'' continuum electrostatic theory. For homogeneous potentials
this last model describes also the weak coupling limit for arbitrary
. Important steps in the proof are the derivation of a new Lieb-Thirring
inequality for the sum of eigenvalues of single particle Hamiltonians in 2D
with magnetic fields, and an estimation of the exchange-correlation energy. For
this last estimate we study a model of classical point charges with
electrostatic interactions that provides a lower bound for the true quantum
mechanical energy.Comment: 57 pages, Plain tex, 5 figures in separate uufil
Matter in Strong Magnetic Fields
The properties of matter are significantly modified by strong magnetic
fields, Gauss (), as are typically
found on the surfaces of neutron stars. In such strong magnetic fields, the
Coulomb force on an electron acts as a small perturbation compared to the
magnetic force. The strong field condition can also be mimicked in laboratory
semiconductors. Because of the strong magnetic confinement of electrons
perpendicular to the field, atoms attain a much greater binding energy compared
to the zero-field case, and various other bound states become possible,
including molecular chains and three-dimensional condensed matter. This article
reviews the electronic structure of atoms, molecules and bulk matter, as well
as the thermodynamic properties of dense plasma, in strong magnetic fields,
. The focus is on the basic physical pictures and
approximate scaling relations, although various theoretical approaches and
numerical results are also discussed. For the neutron star surface composed of
light elements such as hydrogen or helium, the outermost layer constitutes a
nondegenerate, partially ionized Coulomb plasma if , and may be in
the form of a condensed liquid if the magnetic field is stronger (and
temperature K). For the iron surface, the outermost layer of the
neutron star can be in a gaseous or a condensed phase depending on the cohesive
property of the iron condensate.Comment: 45 pages with 9 figures. Many small additions/changes. Accepted for
publication in Rev. Mod. Phy
Botulinum Neurotoxin D Uses Synaptic Vesicle Protein SV2 and Gangliosides as Receptors
Botulinum neurotoxins (BoNTs) include seven bacterial toxins (BoNT/A-G) that target presynaptic terminals and act as proteases cleaving proteins required for synaptic vesicle exocytosis. Here we identified synaptic vesicle protein SV2 as the protein receptor for BoNT/D. BoNT/D enters cultured hippocampal neurons via synaptic vesicle recycling and can bind SV2 in brain detergent extracts. BoNT/D failed to bind and enter neurons lacking SV2, which can be rescued by expressing one of the three SV2 isoforms (SV2A/B/C). Localization of SV2 on plasma membranes mediated BoNT/D binding in both neurons and HEK293 cells. Furthermore, chimeric receptors containing the binding sites for BoNT/A and E, two other BoNTs that use SV2 as receptors, failed to mediate the entry of BoNT/D suggesting that BoNT/D binds SV2 via a mechanism distinct from BoNT/A and E. Finally, we demonstrated that gangliosides are essential for the binding and entry of BoNT/D into neurons and for its toxicity in vivo, supporting a double-receptor model for this toxin
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