Point particle in general background fields vs. free gauge theories of traceless symmetric tensors

Point particle may interact to traceless symmetric tensors of arbitrary rank. Free gauge theories of traceless symmetric tensors are constructed, that provides a possibility for a new type of interactions, when particles exchange by those gauge fields. The gauge theories are parameterized by the particle's mass m and otherwise are unique for each rank s. For m=0, they are local gauge models with actions of 2s-th order in derivatives, known in d=4 as "pure spin", or "conformal higher spin" actions by Fradkin and Tseytlin. For nonzero m, each rank-s model undergoes a unique nonlocal deformation which entangles fields of all ranks, starting from s. There exists a nonlocal transform which maps m > 0 theories onto m=0 ones, however, this map degenerates at some m > 0 fields whose polarizations are determined by zeros of Bessel functions. Conformal covariance properties of the m=0 models are analyzed, the space of gauge fields is shown to admit an action of an infinite-dimensional "conformal higher spin" Lie algebra which leaves gauge transformations intact.Comment: 21 pages, remarks on nonlinear generalization added, a mistake in the discussion of degenerate solutions correcte

A Linearization Beam-Hardening Correction Method for X-Ray Computed Tomographic Imaging of Structural Ceramics

Computed tomographic (CT) imaging with both monochromatic and polychromatic x-ray sources can be a powerful NDE method for characterization (e. g., measurement of density gradients) as well as flaw detection (e. g., detection of cracks, voids, inclusions) in ceramics. However, the use of polychromatic x-ray sources can cause image artifacts and overall image degradation through beam hardening (BH) effects [1]. Beam hardening occurs because (i) x-ray attenuation in a given material is energy dependent and (ii) data collection in CT systems is not energy selective. Without an appropriate correction, the BH effect prevents the establishment of an absolute scale for density measurement. Thus, quantitative density comparisons between samples of the same material but of different geometrical shape becomes unreliable [2]

Module networks revisited: computational assessment and prioritization of model predictions

The solution of high-dimensional inference and prediction problems in computational biology is almost always a compromise between mathematical theory and practical constraints such as limited computational resources. As time progresses, computational power increases but well-established inference methods often remain locked in their initial suboptimal solution. We revisit the approach of Segal et al. (2003) to infer regulatory modules and their condition-specific regulators from gene expression data. In contrast to their direct optimization-based solution we use a more representative centroid-like solution extracted from an ensemble of possible statistical models to explain the data. The ensemble method automatically selects a subset of most informative genes and builds a quantitatively better model for them. Genes which cluster together in the majority of models produce functionally more coherent modules. Regulators which are consistently assigned to a module are more often supported by literature, but a single model always contains many regulator assignments not supported by the ensemble. Reliably detecting condition-specific or combinatorial regulation is particularly hard in a single optimum but can be achieved using ensemble averaging.Comment: 8 pages REVTeX, 6 figure

Transition amplitudes and sewing properties for bosons on the Riemann sphere

We consider scalar quantum fields on the sphere, both massive and massless. In the massive case we show that the correlation functions define amplitudes which are trace class operators between tensor products of a fixed Hilbert space. We also establish certain sewing properties between these operators. In the massless case we consider exponential fields and have a conformal field theory. In this case the amplitudes are only bilinear forms but still we establish sewing properties. Our results are obtained in a functional integral framework.Comment: 33 page

Motif Discovery through Predictive Modeling of Gene Regulation

We present MEDUSA, an integrative method for learning motif models of transcription factor binding sites by incorporating promoter sequence and gene expression data. We use a modern large-margin machine learning approach, based on boosting, to enable feature selection from the high-dimensional search space of candidate binding sequences while avoiding overfitting. At each iteration of the algorithm, MEDUSA builds a motif model whose presence in the promoter region of a gene, coupled with activity of a regulator in an experiment, is predictive of differential expression. In this way, we learn motifs that are functional and predictive of regulatory response rather than motifs that are simply overrepresented in promoter sequences. Moreover, MEDUSA produces a model of the transcriptional control logic that can predict the expression of any gene in the organism, given the sequence of the promoter region of the target gene and the expression state of a set of known or putative transcription factors and signaling molecules. Each motif model is either a $k$-length sequence, a dimer, or a PSSM that is built by agglomerative probabilistic clustering of sequences with similar boosting loss. By applying MEDUSA to a set of environmental stress response expression data in yeast, we learn motifs whose ability to predict differential expression of target genes outperforms motifs from the TRANSFAC dataset and from a previously published candidate set of PSSMs. We also show that MEDUSA retrieves many experimentally confirmed binding sites associated with environmental stress response from the literature.Comment: RECOMB 200

The Yang-Mills equations on the universal cosmos

AbstractGlobal existence and regularity of solutions for the Yang-Mills equations on the universal cosmos M̃, which has the form R1 × S3 for each of an 8-parameter continuum of factorizations of M̃ as time × space, are treated by general methods. The Cauchy problem in the temporal gauge is globally soluble in its abstract evolutionary form with arbitrary data for the field ⊕ potential in L2,r(S3) ⊕ L2,r + 1(S3), where r is an integer >1 and L2,r denotes the class of sections whose first r derivatives are square-integrable; if r = 1, the problem is soluble locally in time. When r is 3 or more the solution is identifiable with a classical one; if infinite, the solution is in C∞(M̃). These results extend earlier work and approaches [1–5]. Solutions of the equations on Minkowski space-time M0 extend canonically (modulo gauge transformations) to solutions on M̃ provided their Cauchy data are moderately smooth and small near spatial infinity. Precise asymptotic structures for solutions on M0 follow, and in turn imply various decay estimates. Thus the energy in regions uniformly bounded in direction away from the light cone is O(¦x0¦−5), where x0 is the Minkowski time coordinate; analysis solely in M0 [8,9] earlier yielded the estimate O(¦x0¦−2) applicable to the region within the light cone. Similarly it follows that the action integral for a solution of the Yang-Mills equations in M0 is finite, in fact absolutely convergent

Segal-Bargmann-Fock modules of monogenic functions

In this paper we introduce the classical Segal-Bargmann transform starting from the basis of Hermite polynomials and extend it to Clifford algebra-valued functions. Then we apply the results to monogenic functions and prove that the Segal-Bargmann kernel corresponds to the kernel of the Fourier-Borel transform for monogenic functionals. This kernel is also the reproducing kernel for the monogenic Bargmann module.Comment: 11 page

Birkhoff strata of the Grassmannian Gr(2)\mathrm{^{(2)}}: Algebraic curves

Algebraic varieties and curves arising in Birkhoff strata of the Sato Grassmannian Gr${^{(2)}}$ are studied. It is shown that the big cell $\Sigma_0$ contains the tower of families of the normal rational curves of all odd orders. Strata $\Sigma_{2n}$, $n=1,2,3,...$ contain hyperelliptic curves of genus $n$ and their coordinate rings. Strata $\Sigma_{2n+1}$, $n=0,1,2,3,...$ contain $(2m+1,2m+3)-$plane curves for $n=2m,2m-1$ $(m \geq 2)$ and $(3,4)$ and $(3,5)$ curves in $\Sigma_3$, $\Sigma_5$ respectively. Curves in the strata $\Sigma_{2n+1}$ have zero genus.Comment: 14 pages, no figures, improved some definitions, typos correcte

Supergeometry and Quantum Field Theory, or: What is a Classical Configuration?

We discuss of the conceptual difficulties connected with the anticommutativity of classical fermion fields, and we argue that the "space" of all classical configurations of a model with such fields should be described as an infinite-dimensional supermanifold M. We discuss the two main approaches to supermanifolds, and we examine the reasons why many physicists tend to prefer the Rogers approach although the Berezin-Kostant-Leites approach is the more fundamental one. We develop the infinite-dimensional variant of the latter, and we show that the functionals on classical configurations considered in a previous paper are nothing but superfunctions on M. We present a programme for future mathematical work, which applies to any classical field model with fermion fields. This programme is (partially) implemented in successor papers.Comment: 46 pages, LateX2E+AMSLaTe