The PPP hypothesis revisited: Evidence using a multivariate long-memory model

This paper examines the PPP hypothesis analysing the behaviour of the real exchange rates vis-à-vis the US dollar for four major currencies (namely, the Canadian dollar, the euro, the Japanese yen and the British pound). An innovative approach based on fractional integration in a multivariate context is applied to annual data from 1970 to 2011. Long memory is found to characterise the Canadian dollar, the British pound and the euro, but in all four cases the results are consistent with the relative version of PPP

Explore parameter sensitivities and model calibration in a locally coupled environment

A locally coupled Single Column Model (SCM) was used for sensitivity analysis and model calibration. The sensitivity analysis was used to identify 32 land-surface parameters which appeared to be more or less sensitive in the locally coupled environment. The multi-objective sensitive analysis shows that the land surface-atmosphere interactions could have significant influences on the model parameter sensitivities. The calibration results suggest that it is crucial to include both land-surface and atmospheric parameters in the calibration of a coupled land surface model

Exploring parameter sensitivities of the land surface using a locally coupled land-atmosphere model

This paper presents a multicriteria analysis that explores the sensitivity of the land surface to changes in both land and atmospheric parameters, in terms of reproducing surface heat fluxes and ground temperature; for the land parameters, offline sensitivity analyses were also conducted for comparison to infer the influence of land-atmosphere interactions. A simple "one-at-a-time" sensitivity analysis was conducted first to filter out some insensitive parameters, followed by a multicriteria sensitivity analysis using the multiobjective generalized sensitivity analysis algorithm. The models used were the locally coupled National Center for Atmospheric Research (NCAR) single-column community climate model and the offline NCAR land surface model, driven and evaluated by a summer intensive operational periods (IOP) data set from the southern Great Plains. As expected, the results show that land-atmosphere interactions (with or without land-atmosphere parameter interactions) can have significant influences on the sensitivity of the land surface to changes in the land parameters, and the single-criterion sensitivities can be significantly different from the multicriteria sensitivity. These findings are mostly model and data independent and can be generally useful, regardless of the model/data dependence of the sensitivities of individual parameters. The exceptionally high sensitivities of the selected atmospheric parameters in a multicriteria sense (and in particular for latent heat) appeal for adequate attention to the specification of effective values of these parameters in an atmospheric model. Overall, this study proposes an effective framework of multicriteria sensitivity analysis beneficial to future studies in the development and parameter estimation of other complex (offline or coupled) land surface models. Copyright 2004 by the American Geophysical Union

Identification of a carbohydrate-based endothelial ligand for a lymphocyte homing receptor.

Lymphocyte attachment to high endothelial venules within lymph nodes is mediated by the peripheral lymph node homing receptor (pnHR), originally defined on mouse lymphocytes by the MEL-14 mAb. The pnHR is a calcium-dependent lectin-like receptor, a member of the LEC-CAM family of adhesion proteins. Here, using a soluble recombinant form of the homing receptor, we have identified an endothelial ligand for the pnHR as an approximately 50-kD sulfated, fucosylated, and sialylated glycoprotein, which we designate Sgp50 (sulfated glycoprotein of 50 kD). Recombinant receptor binding to this lymph node-specific glycoprotein requires calcium and is inhibitable by specific carbohydrates and by MEL-14 mAb. Sialylation of the component is required for binding. Additionally, the glycoprotein is precipitated by MECA-79, an adhesion-blocking mAb reactive with lymph node HEV. A related glycoprotein of approximately 90 kD (designated as Sgp90) is also identified

Semantic bottleneck for computer vision tasks

This paper introduces a novel method for the representation of images that is semantic by nature, addressing the question of computation intelligibility in computer vision tasks. More specifically, our proposition is to introduce what we call a semantic bottleneck in the processing pipeline, which is a crossing point in which the representation of the image is entirely expressed with natural language , while retaining the efficiency of numerical representations. We show that our approach is able to generate semantic representations that give state-of-the-art results on semantic content-based image retrieval and also perform very well on image classification tasks. Intelligibility is evaluated through user centered experiments for failure detection

Phenotypic and functional analysis of positive selection in the gamma/delta T cell lineage.

Recent evidence suggests that T cells expressing gamma/delta antigen receptors (T cell receptor [TCR]) are subject to positive selection during development. We have shown that T cells expressing a class I major histocompatibility complex (MHC)-specific gamma/delta TCR transgene (tg) are not positively selected in class I MHC-deficient, beta 2-microglobulin (beta 2m) gene knockout mice (tg+ beta 2m-). In this report, we examine phenotypic and functional parameters of gamma/delta positive selection in this transgenic model system. TCR-gamma/delta tg+ thymocytes of mature surface phenotype (heat stable antigen-, CD5hi) were found in beta 2m+ but not in beta 2m- mice. Moreover, subsets of tg+ thymocytes with the phenotype of activated T cells (interleukin [IL]2R+, CD44hi, or Mel-14lo) were also present only in the beta 2m+ mice. Cyclosporine A, which blocks positive selection of TCR-alpha/beta T cells, also inhibited gamma/delta tg+ T cell development. These results support the idea that positive selection of TCR-gamma/delta requires active TCR-mediated signal transduction. Whereas tg+ beta 2m+ thymocytes produced IL-2 and proliferated when stimulated by alloantigen, TCR engagement of tg+ beta 2m- thymocytes by antigen induced IL-2R expression but was uncoupled from the signal transduction pathway leading to IL-2 production and autocrine proliferation. Overall, these results demonstrate significant parallels between gamma/delta and alpha/beta lineage development, and suggest a general role for TCR signaling in thymic maturation

Pinning by a sparse potential

We consider a directed polymer interacting with a diluted pinning potential restricted to a line. We characterize explicitely the set of disorder configurations that give rise to localization of the polymer. We study both relevant cases of dimension 1+1 and 1+2. We also discuss the case of massless effective interface models in dimension 2+1.Comment: to appear in Stochastic Processes and their Application