1,291 research outputs found
Renormalization Group Equations for the CKM matrix
We derive the one loop renormalization group equations for the
Cabibbo-Kobayashi-Maskawa matrix for the Standard Model, its two Higgs
extension and the minimal supersymmetric extension in a novel way. The derived
equations depend only on a subset of the model parameters of the
renormalization group equations for the quark Yukawa couplings so the CKM
matrix evolution cannot fully test the renormalization group evolution of the
quark Yukawa couplings. From the derived equations we obtain the invariant of
the renormalization group evolution for three models which is the angle
of the unitarity triangle. For the special case of the Standard Model
and its extensions with we demonstrate that also the shape
of the unitarity triangle and the Buras-Wolfenstein parameters
and
are conserved. The invariance of the angles of the unitarity triangle means
that it is not possible to find a model in which the CKM matrix might have a
simple, special form at asymptotic energies.Comment: 9 page
Early star formation traced by the highest redshift quasars
The iron abundance relative to alpha-elements in the circumnuclear region of
quasars is regarded as a clock of the star formation history and, more
specifically, of the enrichment by SNIa. We investigate the iron abundance in a
sample of 22 quasars in the redshift range 3.0<z<6.4 by measuring their rest
frame UV FeII bump, which is shifted into the near-IR, and by comparing it with
the MgII 2798 flux. The observations were performed with a device that can
obtain near-IR spectra in the range 0.8-2.4 um in one shot, thereby enabling an
optimal removal of the continuum underlying the FeII bump. We detect iron in
all quasars including the highest redshift (z=6.4) quasar currently known. The
uniform observational technique and the wide redshift range allows a reliable
study of the trend of the FeII/MgII ratio with redshift. We find the FeII/MgII
ratio is nearly constant at all redshifts, although there is marginal evidence
for a higher FeII/MgII ratio in the quasars at z~6. If the FeII/MgII ratio
reflects the Fe/alpha abundance, this result suggests that the z~6 quasars have
already undergone a major episode of iron enrichment. We discuss the possible
implications of this finding for the star formation history at z>6. We also
detect a population of weak iron emitters at z~4.5, which are possibly hosted
in systems that evolved more slowly. Alternatively, the trend of the FeII/MgII
ratio at high redshift may reflect significantly different physical conditions
of the circumnuclear gas in such high redshift quasars.Comment: Replaced to match the accepted version (ApJL in press), 5 page
Cytochrome P450 from Plants: Platforms for Valuable Phytopharmaceuticals
Cytochrome P450 enzymes are important for biotechnology due to their capacity to modify diverse secondary metabolites that may produce chemicals with pharmacological properties. Most terpenes, flavonoids and alkaloids require P450 catalytic functions to reach their biological activity. In the last ten years, several efforts have focused on the expression and production of these three main types of secondary metabolites in engineered microorganisms and plants using P450 of ethnobotanical origin. Despite this, several P450 coding sequences from plant sources are discovered yearly but only a few have been screened by functional genomics. Amongst them, only a few have shown potentials for use in sustainable production of novel drugs and highly valuable products. Cytochrome P450 involvement in the biosynthesis of these products is discussed in this work.Keywords: Biotechnological platforms, Cytochrome P450, Phytopharmaceuticals, Yield improvement, Terpenes, Flavonoids, Alkaloids, Microbial expressio
Multi-component Transparent Conducting Oxides: Progress in Materials Modelling
Transparent conducting oxides (TCOs) play an essential role in modern
optoelectronic devices through their combination of electrical conductivity and
optical transparency. We review recent progress in our understanding of
multi-component TCOs formed from solid-solutions of ZnO, In2O3, Ga2O3 and
Al2O3, with a particular emphasis on the contributions of materials modelling,
primarily based on Density Functional Theory. In particular, we highlight three
major results from our work: (i) the fundamental principles governing the
crystal structures of multi-component oxide structures including (In2O3)(ZnO)n,
named IZO, and (In2O3)m(Ga2O3)l(ZnO)n, named IGZO; (ii) the relationship
between elemental composition and optical and electrical behaviour, including
valence band alignments; (iii) the high-performance of amorphous oxide
semiconductors. From these advances, the challenge of the rational design of
novel electroceramic materials is discussed.Comment: Part of a themed issue of Journal of Physics: Condensed Matter on
"Semiconducting Oxides". In Press (2011
Bayesian variable selection using partially observed categorical prior information in fine-mapping association studies
Several methods have been proposed to allow functional genomic information to inform prior distributions in Bayesian fineâmapping caseâcontrol association studies. None of these methods allow the inclusion of partially observed functional genomic information. We use functional significance (FS) scores that combine information across multiple bioinformatics sources to inform our effect size prior distributions. These scores are not available for all singleânucleotide polymorphisms (SNPs) but by partitioning SNPs into naturally occurring FS score groups, we show how missing FS scores can easily be accommodated via finite mixtures of elicited priors. Most current approaches adopt a formal Bayesian variable selection approach and either limit the number of causal SNPs allowed or use approximations to avoid the need to explore the vast parameter space. We focus instead on achieving differential shrinkage of the effect sizes through prior scale mixtures of normals and use marginal posterior probability intervals to select candidate causal SNPs. We show via a simulation study how this approach can improve localisation of the causal SNPs compared to existing mutliâSNP fineâmapping methods. We also apply our approach to fineâmapping a region around the CASP8 gene using the iCOGS consortium breast cancer SNP data
The Public Health Exposome: A Population-Based, Exposure Science Approach to Health Disparities Research
The lack of progress in reducing health disparities suggests that new approaches are needed if we are to achieve meaningful, equitable, and lasting reductions. Current scientific paradigms do not adequately capture the complexity of the relationships between environment, personal health and population level disparities. The public health exposome is presented as a universal exposure tracking framework for integrating complex relationships between exogenous and endogenous exposures across the lifespan from conception to death. It uses a social-ecological framework that builds on the exposome paradigm for conceptualizing how exogenous exposures âget under the skinâ. The public health exposome approach has led our team to develop a taxonomy and bioinformatics infrastructure to integrate health outcomes data with thousands of sources of exogenous exposure, organized in four broad domains: natural, built, social, and policy environments. With the input of a transdisciplinary team, we have borrowed and applied the methods, tools and terms from various disciplines to measure the effects of environmental exposures on personal and population health outcomes and disparities, many of which may not manifest until many years later. As is customary with a paradigm shift, this approach has far reaching implications for research methods and design, analytics, community engagement strategies, and research training
Mucosal Eosinophil Abundance in Non-Inflamed Colonic Tissue Is Associated with Response to Vedolizumab Induction Therapy in Inflammatory Bowel Disease
Vedolizumab is used as a treatment for patients with inflammatory bowel disease (IBD), but induction therapy leads to clinical response and remission in approximately 55% and 30% of patients with IBD, respectively. In this study, we aimed to explore the predictive value of mucosal eosinophils and serum eotaxin-1 regarding response to vedolizumab induction therapy. Eighty-four (84) patients with IBD (37 Crohnâs disease [CD], 47 ulcerative colitis [UC]) were included. For 24 patients with IBD, histopathology was assessed for eosinophil counts in non-inflamed colonic tissue prior to vedolizumab treatment. For 64 patients with IBD, serum eotaxin-1 levels were quantified prior to (baseline) and during vedolizumab treatment. Serum samples of 100 patients with IBD (34 CD, 66 UC) from the GEMINI 1 and 2 trials were used for external validation. Baseline mucosal eosinophil numbers in non-inflamed colonic tissue were significantly higher in responders to vedolizumab induction therapy when compared to primary non-responders (69 [34â138] vs. 24 [18â28] eosinophils/high-power field, respectively, p < 0.01). Baseline serum eotaxin-1 levels in the discovery cohort were significantly elevated in responders, compared to primary non-responders (0.33 [0.23â0.44] vs. 0.20 [0.16â0.29] ng/mL, p < 0.01). Prediction models based on mucosal eosinophil counts and serum eotaxin-1 showed an area under the curve (AUC) of 0.90 and 0.79, respectively. However, the predictive capacity of baseline serum eotaxin-1 levels could not be validated in the GEMINI cohort. Mucosal eosinophil abundance in non-inflamed colonic tissue was associated with response to vedolizumab induction therapy in patients with IBD. Future studies are warranted to further validate the potential value of mucosal eosinophils and serum eotaxin-1 as biomarkers for response to vedolizumab therapy
Parametric Forcing of Waves with Non-Monotonic Dispersion Relation: Domain Structures in Ferrofluids?
Surface waves on ferrofluids exposed to a dc-magnetic field exhibit a
non-monotonic dispersion relation. The effect of a parametric driving on such
waves is studied within suitable coupled Ginzburg-Landau equations. Due to the
non-monotonicity the neutral curve for the excitation of standing waves can
have up to three minima. The stability of the waves with respect to long-wave
perturbations is determined a phase-diffusion equation. It shows that the
band of stable wave numbers can split up into two or three sub-bands. The
resulting competition between the wave numbers corresponding to the respective
sub-bands leads quite naturally to patterns consisting of multiple domains of
standing waves which differ in their wave number. The coarsening dynamics of
such domain structures is addressed.Comment: 23 pages, 6 postscript figures, composed using RevTeX. Submitted to
PR
Mucosal eosinophil abundance in non-inflamed colonic tissue predicts response to vedolizumab induction therapy in inflammatory bowel disease
Vedolizumab is used as a treatment for patients with inflammatory bowel disease (IBD), but induction therapy leads to clinical response and remission in approximately 55% and 30% of patients with IBD, respectively. In this study, we aimed to explore the predictive value of mucosal eosinophils and serum eotaxin-1 regarding response to vedolizumab induction therapy. Eighty-four (84) patients with IBD (37 Crohnâs disease [CD], 47 ulcerative colitis [UC]) were included. For 24 patients with IBD, histopathology was assessed for eosinophil counts in non-inflamed colonic tissue prior to vedolizumab treatment. For 64 patients with IBD, serum eotaxin-1 levels were quantified prior to (baseline) and during vedolizumab treatment. Serum samples of 100 patients with IBD (34 CD, 66 UC) from the GEMINI 1 and 2 trials were used for external validation. Baseline mucosal eosinophil numbers in non-inflamed colonic tissue were significantly higher in responders to vedolizumab induction therapy when compared to primary non-responders (69 [34â138] vs. 24 [18â28] eosinophils/high-power field, respectively, p < 0.01). Baseline serum eotaxin-1 levels in the discovery cohort were significantly elevated in responders, compared to primary non-responders (0.33 [0.23â0.44] vs. 0.20 [0.16â0.29] ng/mL, p < 0.01). Prediction models based on mucosal eosinophil counts and serum eotaxin-1 showed an area under the curve (AUC) of 0.90 and 0.79, respectively. However, the predictive capacity of baseline serum eotaxin-1 levels could not be validated in the GEMINI cohort. Mucosal eosinophil abundance in non-inflamed colonic tissue was associated with response to vedolizumab induction therapy in patients with IBD. Future studies are warranted to further validate the potential value of mucosal eosinophils and serum eotaxin-1 as biomarkers for response to vedolizumab therapy
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