Cereal cultivars innovations adapted to organic production: A new challenge

To face and better manage the development of new varieties in a society calling for more and more transparency, the French National Research Institute (INRA) has get involved in an ambitious reflexive program about the question of "impacts, acceptability and management of varietal innovations" engaging all its thematic research departments. New collaboration between social and technical sciences are promoted to produce, from exemplary case studies, generic concepts and tools to assess the different types of impact of a new variety. Breeding and management of new genetic materials adapted to organic farming conditions constitute an appropriate theme to develop such an integrated process. A pluridisciplinary research team, associating plant breeders, soil scientists, ecologists, agronomists, economists, sociologists, in close collaboration with professionals , will try to assess both the agroenvironmental and socioeconomic impacts of changes, by studying current dynamics around original durum wheat and rice cultivars adapted to organic production in different territories

Diversity of organic farming systems: Challenges for the construction of markets, varieties and plant breeding techniques

New societal values call for the diversification of agriculture to fit contrasted environments. This process can be depicted by four models defined by two axes, a socio-economic axis (individual logic vs. collective governance), and an agro-ecological axis (analytical vs. systemic approaches). These models differ in: (i) their objectives (from improvement in yield to the empowerment of farmers), (ii) their specific expectations with respect to genotypes (from inherited genetic resources to varieties that represent genetic, ethical and social progress), and (iii) their representations of the environment (from a simple interaction between the bio-physical environment and crop management, to a complex interaction including the skills of stakeholders, outlets, regulations and society). Taking this diversity into account changes the way plant improvement is envisioned. Depending on the model, the five classic stages of plant improvement (setting objectives, creating variability, selecting, evaluating and disseminating) may be called into question. Between the existing analytical model (model I) and a holistic model (model IV) that remains to be developed, lies the challenge of ensuring the sustainability, efficiency and acceptability of plant breeding and resulting innovations

From Ideotype to Realtype concept: Dynamic management of plant breeding by a multidisciplinary and participatory way. Example of organic durum wheat

A travers l’exemple du blé dur, les auteurs explorent l’évolution temporelle de la notion d’idéotype mais aussi comment la diversification actuelle des environnements en AB influe sur la diversification des idéotypes et rend nécessaire une démarche dynamique et participative d’amélioration des plantes. Cette façon renouvelée de concevoir et gérer la sélection amène à dépasser la notion d’idéotype, qui reste associée à des critères de sélection a priori, pour préférer le terme de « realtype », qui traduirait la mise à l’épreuve de l’idéotype à la réalité des terrains. Ce n’est donc pas la construction de l’idéotype « par rapport à » mais bien « dans » le contexte qui est recherché et permise par un dispositif collectif représentant la diversité des acteurs concernés et des compétences nécessaires

A comparison of surgical devices for grade II and III hemorrhoidal disease. Results from the LigaLongo Trial comparing transanal Doppler-guided hemorrhoidal artery ligation with mucopexy and circular stapled hemorrhoidopexy

PURPOSE: Little is presently known on the impact of device type for Doppler-guided hemorrhoidal artery ligation/mucopexy (DGHAL) or circular stapled hemorrhoidopexy (CSH) when a surgical treatment is considered for hemorrhoidal disease (HD). In this study, we aimed to compare the outcome in terms of adverse events and recurrence rate, of patients included in the multicenter LigaLongo RCT ( ClinicalTrials.gov NCT01240772) according to the type of devices used. METHODS: In the DGHAL arm (N = 193), the procedure was done with transanal hemorrhoidal dearterialization (THD)™ (THD, Correggio, Italy) (104 patients) and with HAL-RAR™ (Agency for Medical Innovations (AMI) GmbH, Feldkirch, Austria) (89 patients). In the CSH arm (N = 184), procedure for prolapse and hemorrhoids (PPH)-03™ (Ethicon Endo-Surgery, Cincinnati OH) and hemorrhoidopexy and prolapse (HEM)™ (Covidien, Inc.) staplers were used in respectively 106 and 78 cases. Surgery-related morbidity at 90 postoperative days (POD) based on the Clavien-Dindo procedure-related complication score and clinical outcome in terms of recurrence and reoperation rate at 12 postoperative months (POM) was collected. RESULTS: Three hundred and seventy-seven patients were randomized according to HD grade. In the DGHAL arm, the number of ligations and mucopexies was higher in the AMI group (p < 0.0001); at 90 POD, the overall morbidity was similar between the two groups. In the CSH arm, donut sizes were similar; at 90 POD, the PPH group had a higher risk of postoperative grade 1 morbidity (anal urgency or incontinence) compared to the HEM group (p = 0.003). At 12 POM, no statistical difference was found between the two groups of each arm in terms of grade III recurrence or reoperation. CONCLUSION: Postoperative morbidity and outcome at 1 year were similar regardless of the type of devices used. These findings suggest that device type has little impact on HD treatment results. TRIAL REGISTRATION: clinicaltrials.gov -Identifier NCT01240772

Transplantation tolerance: lessons from experimental rodent models

Immunological tolerance or functional unresponsiveness to a transplant is arguably the only approach that is likely to provide long-term graft survival without the problems associated with life-long global immunosuppression. Over the past 50 years, rodent models have become an invaluable tool for elucidating the mechanisms of tolerance to alloantigens. Importantly, rodent models can be adapted to ensure that they reflect more accurately the immune status of human transplant recipients. More recently, the development of genetically modified mice has enabled specific insights into the cellular and molecular mechanisms that play a key role in both the induction and maintenance of tolerance to be obtained and more complex questions to be addressed. This review highlights strategies designed to induce alloantigen specific immunological unresponsiveness leading to transplantation tolerance that have been developed through the use of experimental models

Metals impact into the Paranaguá Estuarine Complex (Brazil) during the exceptional flood of 2011

Abstract Particulate and dissolved metal concentrations were determined after the largest flood in the last 30 years on the east-west axis of the Paranaguá Estuarine Complex (PEC) and compared to the those of the dry period at two stations. Results confirmed that the flood greatly affected riverine outflows and the behavior of metals in the PEC. In particular, a sharp decrease in salinity was followed by extremely high SPM concentrations leading to a decrease in DO concentrations at both stations. For the dissolved phase, ANOSIM analysis showed a significant dissimilarity at each station between the sampled periods, whereas for the particulate phase this dissimilarity was found only for the samplings taken at the Antonina Station. KD values suggested dissolved Cu behavior was related to the presence of organic complexes and dissolved Mn had sediment resuspension of redox sediments and or/pore water injection as sources. Metal concentrations were lower than in polluted estuaries, though high enrichment factors found after the flood pointed to the influence of anthropogenic sources. In conclusion, the flood's influence was more evident at the Antonina Station, due to its location in the upper estuary, whereas in Paranaguá a high SPM content with low metal concentration was found, following the common pattern generally found in other marine systems subject to heavy rainfall events