Germ cell ovarian tumor comprises of yolk sac tumor, embryonal carcinoma and immature teratoma: a case report

Yirmi bir yaşındaki hasta, karında şişlik ve ağrı nedeniyle polikliniğe başvurdu. Ultrasonografi muayenesinde orta hatta solid düzgün yüzeyli 12x12 cm boyutlarında adneksiyal kitle saptandı. Manyetik rezonans görüntülemede, batın orta hatta 12x12 cm boyutlarında sol over kaynaklı kitle izlendi. AFP: 702 idi. Laparatomi yapıldı ve sol overde 12x12 cm boyutlarında solid düzgün yüzeyli izlendi. Sol salpingooferektomi yapıldı. Patoloji sonucu %90 yolk sak tümörü, %5 embriyonel karsinom ve %5 immatür teratom geldi. Hasta ameliyat sonrası 4. kür BEP (bleomisin, etoposid, sisplatin) rejimi kemoterapisine devam etmektedir. Miks germ hücreli tümörler agresif seyirlidir ve yeni tedavi stratejilerine ihtiyaç vardır.Istanbul Tip Derg. Yıl: 2010 Cilt: 11 Sayı: 4 185-189 << Geri Yolk Sak Tümör, Embriyonel Karsinom ve İmmatür Teratomdan Oluşan Germ Hücreli Tümör; Olgu Sunumu Ramazan Özyurt1, Mehmet Aytaç Yüksel1, İlkbal Temel1, Remzi Abalı2, Ahmet Birtan Boran1 1İstanbul Eğitim Ve Araştırma Hastanesi, Kadın Hastalıkları Ve Doğum Kliniği, İstanbul 2Namık Kemal Üniversitesi Tıp Fakültesi, Kadın Hastalıkları Ve Doğum Anabilim Dalı, Tekirdağ Yirmi bir yaşındaki hasta, karında şişlik ve ağrı nedeniyle polikliniğe başvurdu. Ultrasonografi muayenesinde orta hatta solid düzgün yüzeyli 12x12 cm boyutlarında adneksiyal kitle saptandı. Manyetik rezonans görüntülemede, batın orta hatta 12x12 cm boyutlarında sol over kaynaklı kitle izlendi. AFP: 702 idi. Laparatomi yapıldı ve sol overde 12x12 cm boyutlarında solid düzgün yüzeyli izlendi. Sol salpingooferektomi yapıldı. Patoloji sonucu %90 yolk sak tümörü, %5 embriyonel karsinom ve %5 immatür teratom geldi. Hasta ameliyat sonrası 4. kür BEP (bleomisin, etoposid, sisplatin) rejimi kemoterapisine devam etmektedir. Miks germ hücreli tümörler agresif seyirlidir ve yeni tedavi stratejilerine ihtiyaç vardır. Anahtar Kelimeler: Embriyonel karsinom, miks germ hücreli ovaryan tümör; immatür teratom; yolk sak tümörü -------------------------------------------------------------------------------- Germ Cell Ovarian Tumor Comprises of Yolk Sac Tumor, Embryonal Carcinoma and Immature Teratoma: A Case Report Ramazan Özyurt1, Mehmet Aytaç Yüksel1, İlkbal Temel1, Remzi Abalı2, Ahmet Birtan Boran1 1Department Of Obstetrics And Gynecology, İstanbul Education And Research Hospital, İstanbul 2Department Of Obstetrics And Gynecology, Namık Kemal University Medical Faculty, Tekirdağ A 21-year-old patient, complaining abdominal pain and abdominal mass admitted to the clinic. Abdominal ultrasound examination revealed a solid, smooth shaped central mass, 12x12 cm in diameter. MRI confirmed the left ovarian lesion. Patients blood AFP value was 702. A laparotomy was performed and a left ovarian 12x12cm in diameter solid mass was seen. Left salpingo oophorectomy was performed. According to the pathologic examination, the constituent were; yolk sac tumor 90%, embryonal carcinoma 5%, immature teratoma 5%. Patient received chemotherapy consisting bleomisin, etoposid, cisplatin (BEP protocol) postoperatively. New treatment approaches for these agressive tumors are needed

Turner syndrome and associated problems in turkish children: A multicenter study

Objective: Turner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and on the genetic background of affected girls. This study aimed to systematically investigate the key clinical features of TS in relationship to karyotype in a large pediatric Turkish patient population. Methods: Our retrospective study included 842 karyotype-proven TS patients aged 0-18 years who were evaluated in 35 different centers in Turkey in the years 2013-2014. Results: The most common karyotype was 45,X (50.7%), followed by 45,X/46,XX (10.8%), 46,X,i(Xq) (10.1%) and 45,X/46,X,i(Xq) (9.5%). Mean age at diagnosis was 10.2±4.4 years. The most common presenting complaints were short stature and delayed puberty. Among patients diagnosed before age one year, the ratio of karyotype 45,X was significantly higher than that of other karyotype groups. Cardiac defects (bicuspid aortic valve, coarctation of the aorta and aortic stenosi) were the most common congenital anomalies, occurring in 25% of the TS cases. This was followed by urinary system anomalies (horseshoe kidney, double collector duct system and renal rotation) detected in 16.3%. Hashimoto’s thyroiditis was found in 11.1% of patients, gastrointestinal abnormalities in 8.9%, ear nose and throat problems in 22.6%, dermatologic problems in 21.8% and osteoporosis in 15.3%. Learning difficulties and/or psychosocial problems were encountered in 39.1%. Insulin resistance and impaired fasting glucose were detected in 3.4% and 2.2%, respectively. Dyslipidemia prevalence was 11.4%. Conclusion: This comprehensive study systematically evaluated the largest group of karyotype-proven TS girls to date. The karyotype distribution, congenital anomaly and comorbidity profile closely parallel that from other countries and support the need for close medical surveillance of these complex patients throughout their lifespan. © Journal of Clinical Research in Pediatric Endocrinology

Germ Cell Ovarian Tumor Comprises of Yolk Sac Tumor, Embryonal Carcinoma and Immature Teratoma: A Case Report

A 21-year-old patient, complaining abdominal pain and abdominal mass admitted to the clinic. Abdominal ultrasound examination revealed a solid, smooth shaped central mass, 12x12 cm in diameter. MRI confirmed the left ovarian lesion. Patients blood AFP value was 702. A laparotomy was performed and a left ovarian 12x12cm in diameter solid mass was seen. Left salpingo oophorectomy was performed. According to the pathologic examination, the constituent were; yolk sac tumor 90%, embryonal carcinoma 5%, immature teratoma 5%. Patient received chemotherapy consisting bleomisin, etoposid, cisplatin (BEP protocol) postoperatively. New treatment approaches for these agressive tumors are needed

Primary ovarian pregnancy: A report of four cases

Primary ovarian pregnancy is a rare form of ectopic pregnancy that constitutes 0.15-3 % of all ectopic pregnancies. Ovarian pregnancy results from the fertilization of trapped ovum within the follicle. Exact preoperative diagnosis is often difficult, and with a few exceptions, the initial diagnosis is made on the operation table and the final diagnosis only through histopathology. The treatment of choice for ovarian pregnancy is usually ovarian wedge resection or oophorectomy, also there is a place for medical treatment of selected patients. Between October 2005 and May 2010, four cases of ovarian pregnancy that were detected and treated during laparotomy for suspected rupture of ectopic pregnancy are described. Three cases were treated by ovarian wedge resection. In one case, a single dose of 50 mg/m2 methotrexate treatment was given, but the same mentioned surgical procedure were performed due to rupture of gestation. In all cases diagnoses were confirmed by pathologic examination. We aimed to discuss a rare form of ectopic pregnancy, primary ovarian pregnancy, and highlight the diagnostic criteria

Clinicopathological evaluation of cervical polyps

Amaç: Servikal polipli hastaların klinikopatolojik ve demografik özellikleri incelendi. Gereç ve Yöntem: İstanbul Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Kliniği’nde Ocak 2006 ile Aralık 2010 yılları arasında servikal polip nedeniyle tedavi edilen 381 hastanın verileri geriye dönük olarak incelendi. Hastalar yaşlarına göre dört gruba ayrıldı; Grup I: 55. Hastaların, polip çapları, semptomları ve histopatolojik tanıları karşılaştırıldı. Bulgular: Hastaların ortalama yaşı 50,36±9,36 idi. Poliplerin ortalama çapı; 12,46±8,31 mm idi. Nüks oranı %1,8 (7/381) idi. Poliplerin büyük çoğunluğu asemptomatikdi (%66,1). Servikal poliplerde primer malignensi saptanmadı. Dört grup arasında çap, semptom, nüks oranı ve histopatolojik tanı açısından istatistiki bir fark yoktu (p>0,05). Sonuç: Servikal polipler iyi huylu lezyonlardır. Çoğu servikal polipler asemptomatik olup rutin jinekolojik muayene sırasında tespit edilirler. Çıkarılmalarının kolay olması, diğer patolojileri ekarte etmek için patolojik değerlendirme gerekliliğinden dolayı rutin çıkarılması mantıklı olabilir.Objectives: The aim of this study was to evaluate the clinicopathologic and demographic features in patients with cervical polyps. Methods: We performed a search of the database to retrieve all cases with a cervical polyp who were treated in the Obstetrics and Gynecology Department of Istanbul Education and Research Hospital between January 2006 and December 2010. The patients’ symptoms and the size and histopathologic diagnosis of the polyp were reviewed. Patients were divided into four age groups as: Group I: <30, Group II: 30-44, Group III: 45-55, and Group IV: >55 years. Results: The mean age was 50.36±9.36 years. The mean polyp size was 12.46±8.31 mm and the recurrence rate was 1.8% (7/381). The majority of cervical polyps were asymptomatic (66.1%). Furthermore, there was no primary malignancy on the cervical polyps. There were no significant differences in terms of diameter, symptoms, rate of recurrence, and histopathologic findings between the four groups (p>0.05). Conclusion: Cervical polyps are benign lesions. Many of them are asymptomatic and are found at the time of routine gynecologic examination. Routine removal of polyps is reasonable and easy; pathological evaluation is needed to rule out other possibilities

Report of surgical correction of a cervicovaginal agenesis case: cervicovaginal reconstruction with pudendal thigh flaps

[No Abstract Available

Clinicopathological Evaluation of Cervical Polyps

Objectives: The aim of this study was to evaluate the clinicopathologic and demographic features in patients with cervical polyps. Methods: We performed a search of the database to retrieve all cases with a cervical polyp who were treated in the Obstetrics and Gynecology Department of Istanbul Education and Research Hospital between January 2006 and December 2010. The patients' symptoms and the size and histopathologic diagnosis of the polyp were reviewed. Patients were divided into four age groups as: Group I: 55 years. Results: The mean age was 50.36 +/- 9.36 years. The mean polyp size was 12.46 +/- 8.31 mm and the recurrence rate was 1.8% (7/381). The majority of cervical polyps were asymptomatic (66.1%). Furthermore, there was no primary malignancy on the cervical polyps. There were no significant differences in terms of diameter, symptoms, rate of recurrence, and histopathologic findings between the four groups (p>0.05). Conclusion: Cervical polyps are benign lesions. Many of them are asymptomatic and are found at the time of routine gynecologic examination. Routine removal of polyps is reasonable and easy; pathological evaluation is needed to rule out other possibilities

Clinico-pathological evaluation of cervical polyps

Amaç: Servikal polipli hastaların klinikopatolojik ve demografik özellikleri incelendi. Gereç ve Yöntem: İstanbul Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Kliniği’nde Ocak 2006 ile Aralık 2010 yılları arasında servikal polip nedeniyle tedavi edilen 381 hastanın verileri geriye dönük olarak incelendi. Hastalar yaşlarına göre dört gruba ayrıldı; Grup I: 55. Hastaların, polip çapları, semptomları ve histopatolojik tanıları karşılaştırıldı. Bulgular: Hastaların ortalama yaşı 50,36±9,36 idi. Poliplerin ortalama çapı; 12,46±8,31 mm idi. Nüks oranı %1,8 (7/381) idi. Poliplerin büyük çoğunluğu asemptomatikdi (%66,1). Servikal poliplerde primer malignensi saptanmadı. Dört grup arasında çap, semptom, nüks oranı ve histopatolojik tanı açısından istatistiki bir fark yoktu (p>0,05). Sonuç: Servikal polipler iyi huylu lezyonlardır. Çoğu servikal polipler asemptomatik olup rutin jinekolojik muayene sırasında tespit edilirler. Çıkarılmalarının kolay olması, diğer patolojileri ekarte etmek için patolojik değerlendirme gerekliliğinden dolayı rutin çıkarılması mantıklı olabilir.Objectives: The aim of this study was to evaluate the clinicopathologic and demographic features in patients with cervical polyps. Methods: We performed a search of the database to retrieve all cases with a cervical polyp who were treated in the Obstetrics and Gynecology Department of Istanbul Education and Research Hospital between January 2006 and December 2010. The patients’ symptoms and the size and histopathologic diagnosis of the polyp were reviewed. Patients were divided into four age groups as: Group I: <30, Group II: 30-44, Group III: 45-55, and Group IV: >55 years. Results: The mean age was 50.36±9.36 years. The mean polyp size was 12.46±8.31 mm and the recurrence rate was 1.8% (7/381). The majority of cervical polyps were asymptomatic (66.1%). Furthermore, there was no primary malignancy on the cervical polyps. There were no significant differences in terms of diameter, symptoms, rate of recurrence, and histopathologic findings between the four groups (p>0.05). Conclusion: Cervical polyps are benign lesions. Many of them are asymptomatic and are found at the time of routine gynecologic examination. Routine removal of polyps is reasonable and easy; pathological evaluation is needed to rule out other possibilities

The effects of isotretinoin on the ovarian reserve of females with acne

There are some side effects of isotretinoin in many organs. However, a study investigating the effects of isotretinoin on the human ovarian reserve has not been reported previously. The study was conducted to investigate possible effects of isotretinoin on ovarian reserve. Serum anti-Mullerian hormone (AMH) levels were measured at the beginning and at the end of isotretinoin treatment in 22 patients with acne and in 22 women without. The mean AMH level before treatment was 5.77 ng/mL in the study group and 3.79 ng/mL in the control group (p =0.008). Following treatment, the mean AMH level was 4.69 ng/mL in the study group. This mean AMH level after treatment was statistically lower than the AMH level before treatment (p= 0.012). There was no significant difference between the mean AMH level at the end of treatment and that of the control group (p= 0.20). The high level of pre-treatment AMH levels could be an evidence of hyperandrogenism in women with acne, even if they are not identified as having polycystic ovary syndrome (PCOS) or hyperandrogenism. Decrease in AMH levels following exposure to isotretinoin may suggest that it has a detrimental effect on the ovaries

Decreased ovarian reserve in female Sprague-Dawley rats induced by isotretinoin exposure

29th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE) -- JUL 07-10, 2013 -- London, ENGLAND[No Abstract Available]European Soc Human Reprod & Embryol (ESHRE