The first Chinese student space shuttle getaway special program

The first Chinese Getaway Special program is described. Program organization, the student proposal evaluation procedure, and the objectives of some of the finalist's experiments are covered. The two experiments selected for eventual flight on the space shuttle are described in detail. These include: (1) the control of debris in the cabin of the space shuttle; and (2) the solidification of two immiscible liquids in space

In-silico design of novel myocilin inhibitors for glaucoma therapy

Purpose: To explore newer computational approaches in the design of novel myocilin inhibitors for the treatment of glaucoma.Methods: An in-silico virtual screening technique based on simulation of molecular docking was utilised to design a novel myocilin inhibitors for the treatment of  glaucoma. The designed novel molecules were theoretically evaluated to predict their pharmacokinetic properties and toxic effects. Lead molecules were screened out in virtual screening technique on the basis of low binding energies obtained in AutoDock based molecular docking simulation.Results: Out of ten top lead compounds screened, ZINC01729523 and ZINC04692015 were promising, having shown potent inhibition of myocilin, good pharmacokinetic properties and absence of any toxic effects.Conclusion: In-silico virtual screening of molecular libraries containing a large number of ligands is very useful for short-listing of potential lead molecules for further structure-based discovery of antiglaucoma-drugs.Keywords: Glaucoma, Myocilin, Docking, Virtual-screening, Autodock, Ligand, Drug desig

4-Amino-3,5-dichloro­benzene­sulfonamide

In the title compound, C6H6Cl2N2O2S, the O atoms of the sulfonamide group lie on one side of the benzene ring and the amino group lies on the opposite side. An inter­molecular N—H⋯Cl inter­action occurs. In the crystal, adjacent mol­ecules are linked by N—H⋯O hydrogen bonds, forming a three-dimensional structure with supporting π–π stacking inter­actions [centroid–centroid distance = 3.7903 (12) Å]. A short Cl⋯Cl contact [3.3177 (10) Å] also occurs