In-phase and anti-phase synchronization in noisy Hodgkin-Huxley neurons

We numerically investigate the influence of intrinsic channel noise on the dynamical response of delay-coupling in neuronal systems. The stochastic dynamics of the spiking is modeled within a stochastic modification of the standard Hodgkin-Huxley model wherein the delay-coupling accounts for the finite propagation time of an action potential along the neuronal axon. We quantify this delay-coupling of the Pyragas-type in terms of the difference between corresponding presynaptic and postsynaptic membrane potentials. For an elementary neuronal network consisting of two coupled neurons we detect characteristic stochastic synchronization patterns which exhibit multiple phase-flip bifurcations: The phase-flip bifurcations occur in form of alternate transitions from an in-phase spiking activity towards an anti-phase spiking activity. Interestingly, these phase-flips remain robust in strong channel noise and in turn cause a striking stabilization of the spiking frequency

Active Brownian motion in a narrow channel

We review recent advances in rectification control of artificial microswimmers, also known as Janus particles, diffusing along narrow, periodically corrugated channels. The swimmer self-propulsion mechanism is modeled so as to incorporate a nonzero torque (propulsion chirality). We first summarize the effects of chirality on the autonomous current of microswimmers freely diffusing in channels of different geometries. In particular, left-right and upside-down asymmetric channels are shown to exhibit different transport properties. We then report new results on the dependence of the diffusivity of chiral microswimmers on the channel geometry and their own self-propulsion mechanism. The self-propulsion torque turns out to play a key role as a transport control parameter.Comment: to be published in Eur. Phys. J Special Topic

Analysis the Role Conflict of Trade Union Chairman and Its Types

With the development of the market economy, the trade union work has become increasingly complex. As a special group, trade union chairman plays multiple roles. On the one hand, the trade union chairman should safeguard the rights and interests of enterprise employees, on the other hand, as the workers of the enterprise, they have to create benefits for the enterprise, this kind of dual role trigger a trade union chairman role conflict. In this paper, through reviewing the relevant literature, from the personal angle of the trade union chairman, trade union chairman of role conflict from three dimensions divided responsibility, time, interests. Through the division of the three dimension classifying trade union chairman of role conflict, and explain the causes of different types of role conflict and the corresponding countermeasures and suggestions, so as to eliminate the role of the trade union chairman conflict, give full play to the role of the trade union chairman

Effect of Corrosion on the Shear Transfer Behavior of Stud Shear Connectors

The effect of corrosion on the shear transfer behavior of stud shear connectors was investigated in this study. Experimental investigation was performed using an innovative test setup for single stud shear connector. Two series of specimens having different stud diameters were fabricated and tested. The test specimens were firstly corroded to different corrosion rates by electronic accelerating method. Loading test were then performed to obtain the load-slip curves and ultimate strengths of corroded test specimens. Corrosion rates were measured from the studs obtained from the failure test specimens. Test results were compared with standard push out test specimens having the similar corrosion rates. It is shown that the test results obtained from the single stud shear connectors are conservative compared with the corroded push test specimens, which prove the validation of single stud shear connector test method. The effect of corrosion on the shear transfer behavior of stud shear connectors was also presented

PPSP: prediction of PK-specific phosphorylation site with Bayesian decision theory

BACKGROUND: As a reversible and dynamic post-translational modification (PTM) of proteins, phosphorylation plays essential regulatory roles in a broad spectrum of the biological processes. Although many studies have been contributed on the molecular mechanism of phosphorylation dynamics, the intrinsic feature of substrates specificity is still elusive and remains to be delineated. RESULTS: In this work, we present a novel, versatile and comprehensive program, PPSP (Prediction of PK-specific Phosphorylation site), deployed with approach of Bayesian decision theory (BDT). PPSP could predict the potential phosphorylation sites accurately for ~70 PK (Protein Kinase) groups. Compared with four existing tools Scansite, NetPhosK, KinasePhos and GPS, PPSP is more accurate and powerful than these tools. Moreover, PPSP also provides the prediction for many novel PKs, say, TRK, mTOR, SyK and MET/RON, etc. The accuracy of these novel PKs are also satisfying. CONCLUSION: Taken together, we propose that PPSP could be a potentially powerful tool for the experimentalists who are focusing on phosphorylation substrates with their PK-specific sites identification. Moreover, the BDT strategy could also be a ubiquitous approach for PTMs, such as sumoylation and ubiquitination, etc

A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter.

The principal barrier to the eradication of HIV/AIDS is the existence of latent viral reservoirs. One strategy to overcome this barrier is to use latency-reversing agents (LRAs) to reactivate the latent proviruses, which can then be eliminated by effective anti-retroviral therapy. Although a number of LRAs have been found to reactivate latent HIV, they have not been used clinically due to high toxicity and poor efficacy. In this study, we report the identification of a chalcone analogue called Amt-87 that can significantly reactivate the transcription of latent HIV provirses and act synergistically with known LRAs such as prostratin and JQ1 to reverse latency. Amt-87 works by activating the human transcriptional elongation factor P-TEFb, a CDK9-cyclin T1 heterodimer that is part of the super elongation complex (SEC) used by the viral encoded Tat protein to activate HIV transcription. Amt-87 does so by promoting the phosphorylation of CDK9 at the T-loop, liberating P-TEFb from the inactive 7SK snRNP, and inducing the formation of the Tat-SEC complex at the viral promoter. Together, our data reveal chalcones as a promising category of compounds that should be further explored to identify effective LRAs for targeted reversal of HIV latency

Techniques for improving the water-flooding of oil fields during the high water-cut stage

International audienceThe multi-layer co-exploitation method is often used in offshore oilfields because of the large spacing between the injection and production wells. As oilfields gradually enter the high water-cut stage, the contradiction between the horizontal and vertical directions becomes more prominent, and the distribution of the remaining oil is more complex. Oilfields are facing unprecedented challenges in further enhancing oil recovery. Using oilfield A, which is in the high water-cut stage, as the research object, we compiled a detailed description of the remaining oil during the high water-cut stage using the information collected during the comprehensive adjustment and infilling of the oilfield. In addition various techniques for tapping the potential reservoir, stabilizing the oil, and controlling the water were investigated. A set of key techniques for the continuous improvement of the efficiency of water injection after comprehensive adjustment of high water-cut fields was generated. Based on the determined configuration of the offshore deltaic reservoir, a set of detailed descriptive methods and tapping technology for extracting the remaining oil in the offshore high water-cut oilfield after comprehensive adjustment was established. By considering the equilibrium displacement and using a new quantitative characterization method that includes displacement, a new technique for determining the quantity of water that needs to be injected into a stratified injection well during the high water-cut stage was established. Based on the principle of flow field intensity reconfiguration, a linear, variable-intensity, alternating injection and withdrawal technique was proposed. With the application of this series of techniques, the increase in the water content was controlled to within 1%, the natural reduction rate was controlled to within 9%, and the production increased by 1.060 × 107 m3

Magmatic record of India-Asia collision

This work was financially co-supported by Chinese Academy of Sciences (XDB03010301) and other Chinese funding agencies (Project 973: 2011CB403102 and 2015CB452604; NSFC projects: 41225006, 41273044, and 41472061).New geochronological and geochemical data on magmatic activity from the India-Asia collision zone enables recognition of a distinct magmatic flare-up event that we ascribe to slab breakoff. This tie-point in the collisional record can be used to back-date to the time of initial impingement of the Indian continent with the Asian margin. Continental arc magmatism in southern Tibet during 80-40 Ma migrated from south to north and then back to south with significant mantle input at 70-43 Ma. A pronounced flare up in magmatic intensity (including ignimbrite and mafic rock) at ca. 52-51 Ma corresponds to a sudden decrease in the India-Asia convergence rate. Geological and geochemical data are consistent with mantle input controlled by slab rollback from ca. 70 Ma and slab breakoff at ca. 53 Ma. We propose that the slowdown of the Indian plate at ca. 51 Ma is largely the consequence of slab breakoff of the subducting Neo-Tethyan oceanic lithosphere, rather than the onset of the India-Asia collision as traditionally interpreted, implying that the initial India-Asia collision commenced earlier, likely at ca. 55 Ma.Publisher PDFPeer reviewe