Factors affecting the flipped classroom in the educational context of Vietnam

In the context of the implementation of the 2018 General Education Program, teachers are required to implement a teaching model oriented to the development of students’ quality and competence. Teachers are encouraged to adapt the flipped classroom model of teaching in schools as its advantages are suitable for novel teaching strategies. This study focuses on analyzing factors affecting the application of this model in the teaching and learning process by collecting feedback from 351 teachers from various cities in Vietnam. The questionnaire included Likert-type questions analyzed by IBM SPSS Statistics version 20 for quantitative analysis and an open question for qualitative analysis with context and personal information. The research-oriented factors focus on the group of potential internal factors (perception, proficiency, desire and readiness of teachers) and the group of external factors (infrastructure, facilities and support resources, training programs). The results showed that those factors include the school’s infrastructure and information communication technology (ICT) condition, the teacher’s ICT competence as well as competence-related teaching and assessment methodologies and the students’ internet access conditions. Finally, the study offers suggestions on how to apply this model in teaching practice to meet the requirements of educational innovation in Vietnam

Factors influencing the urge to buy impulsively of Vietnamese online buying customers towards Biti’s Hunter sport shoes

Our study investigates the factors that drive Vietnamese online shoppers in Ho Chi Minh City (HCMC) to make impulsive purchases of Biti's Hunter sports shoes (BHS), using the Stimulus-Organism-Response (S-O-R) theory and the Technology Acceptance Model (TAM). Mixed methods are applied: in-depth interviews with ten regular online shoppers and focus group discussions with e-commerce managers for qualitative data collection, and survey techniques to gather quantitative data from 319 online shoppers. Data analysis was performed using SPSS 22.0 and AMOS 22.0. Our findings reveal five factors as a stimulus - visual appeal, website ease of use, product availability, portability, and social influence – and three factors as an organism - instant gratification, impulsiveness, and trust, that lead to the response of urge to buy impulsively. Significant positive effects are found among these constructs, except the relationship between portability and impulsiveness, visual appeal, social influence, trust, instant gratification, and urge to buy impulsively

The Role of Social Network Sites in English Language Teaching_Harnessing the Potential of Facebook and YouTube as Learning Tools

This paper provides a comprehensive review of the role of Social Network Sites (SNSs) in the context of English as a Second Language (ESL) and English as a Foreign Language (EFL) teaching and learning. It examines the definitions and potential applications of SNSs, with a specific focus on Facebook and YouTube. The paper discusses the educational and instructional implementations of these SNSs, as well as the challenges and drawbacks faced by both teachers and students when utilizing them. Furthermore, it explores the pedagogical implications of incorporating the cutting-edge features offered by SNSs, aiming to bridge the gap between traditional and technologically driven learning environment

Impact of climate change on meteorological, hydrological and agricultural droughts in the Lower Mekong River Basin: a case study of the Srepok Basin, Vietnam

peer reviewedThe objective of this study is to assess future changes in meteorological, hydrology and agricultural droughts under the impact of changing climate in the Srepok River Basin, a subbasin of LMB, using three drought indices; standardized precipitation index (SPI), standardized runoff index (SRI) and standardized soil moisture index (SSWI). The well-calibrated Soil and Water Assessment Tool (SWAT) is used as a simulation tool to estimate the features of meteorological, hydrological and agricultural droughts. The climate data for the 2016–2040 period is obtained from four different regional climate models; HadGEM3-RA, SNU-MM5, RegCM4 and YSU-RSM, which are downscaled from the HadGEM2-AO GCM. The results show that the severity, duration and frequency of droughts are predicted to increase in the near future for this region. Moreover, the meteorological drought is less sensitive to climate change than the hydrological and agricultural droughts; however, it has a stronger correlation with the hydrological and agricultural droughts as the accumulation period is increased. These findings may be useful for water resources management and future planning for mitigation and adaptation to the climate change impact in the Srepok River Basin

Hydroxyurea synergizes with valproic acid in wild-type p53 acute myeloid leukaemia

Palliative care in acute myeloid leukaemia (AML) is inadequate. For elderly patients, unfit for intensive chemotherapy, median survival is 2–3 months. As such, there is urgent demand for low-toxic palliative alternatives. We have repositioned two commonly administered anti-leukaemia drugs, valproic acid (VPA) and hydroxyurea (HU), as a combination therapy in AML. The anti-leukemic effect of VPA and HU was assessed in multiple AML cell lines confirming the superior anti-leukemic effect of combination therapy. Mechanistic studies revealed that VPA amplified the ability of HU to slow S-phase progression and this correlated with significantly increased DNA damage. VPA was also shown to reduce expression of the DNA repair protein, Rad51. Interestingly, the tumour suppressor protein p53 was revealed to mitigate cell cycle recovery following combination induced arrest. The efficacy of combination therapy was validated in vivo. Combination treatment increased survival in OCI-AML3 and patient-derived xenograft mouse models of AML. Therapy response was confirmed by optical imaging with multiplexed near-infrared labelled antibodies. The combination of HU and VPA indicates significant potential in preclinical models of AML. Both compounds are widely available and well tolerated. We believe that repositioning this combination could significantly enhance the palliative care of patients unsuited to intensive chemotherapy.publishedVersio

THÀNH LẬP SƠ ĐỒ PHÂN BỐ ĐỨT GÃY KHU VỰC BIỂN VEN BỜ NAM TRUNG BỘ TRÊN CƠ SỞ MINH GIẢI TÀI LIỆU ĐỊA CHẤT - ĐỊA VẬT LÝ

The scheme of the faults in South Central coastal region was established on the basis of interpreting the high resolution shallow seismic data and the deep-seismic data, in combination with the previous studies on geodynamics, tectonic evolution, geological hazards of the South Central coastal region. The fault systems were formed based on updated geophysical, geomorphological, tectonophysic and remote sensing data, including 19 faults in 3 directions: Sub-longitudinal (8 faults), NE-SW (7 faults) and NW-SE (4 faults).Sơ đồ phân bố đứt gãy khu vực biển ven bờ Nam Trung Bộ được thành lập trên cơ sở minh giải, phân tích tài liệu địa chấn nông phân giải cao, địa chấn dầu khí, kết hợp và kế thừa các kết quả nghiên cứu địa chất-địa động lực, tiến hóa kiến tạo. Hệ thống đứt gãy được nghiên cứu, chính xác hóa từ các tài liệu địa vật lý, địa chất-địa mạo, vật lý kiến tạo, viễn thám mới nhất. Trong khu vực có 19 hệ đứt gãy, phát triển theo 3 hướng chính là á kinh tuyến (8 hệ đứt gãy), đông bắc -tây nam (7 hệ đứt gãy) và tây bắc - đông nam (4 hệ đứt gãy)

Cider Production from King Mandarin (Citrus nobilis Lour.) and Its Antioxidant Activity

With the necessity of diversifying alcoholic beverages, cider has become a kind of drink that can fulfill this demand. This is because the cider will be diversified depending on the kinds of fruit that are chosen to be used for the cider fermentation. Therefore, this study aims to investigate the effects of dilution ratio, Brix, pH, and yeast concentration on the production of cider from king mandarin (Citrus nobilis Lour.), and to evaluate the analytical characteristics and antioxidant activity of the product. After the investigation, it can be claimed that the dilution of the juice causes the ethanol content to decrease, whereas the increase of Brix, pH, and yeast concentration makes the ethanol content increase. However, the proportional increase in the ethanol content with Brix, pH, and yeast concentration has its limitations. Specifically, when the Brix and the yeast concentrations were, respectively, higher than 16°Brix and 0.04%, the ethanol content tended to maintain the same. This is also the same when the pH was lower than 4.5. In addition, by using the DPPH and ABTS●+ methods, the antioxidant activity of cider is estimated to be lower than the one of the juice before fermentation, which is smaller than 3.78 times for the DPPH method and 3.76 times for the ABTS●+ method

APOBEC3A Is a Specific Inhibitor of the Early Phases of HIV-1 Infection in Myeloid Cells

Myeloid cells play numerous roles in HIV-1 pathogenesis serving as a vehicle for viral spread and as a viral reservoir. Yet, cells of this lineage generally resist HIV-1 infection when compared to cells of other lineages, a phenomenon particularly acute during the early phases of infection. Here, we explore the role of APOBEC3A on these steps. APOBEC3A is a member of the APOBEC3 family that is highly expressed in myeloid cells, but so far lacks a known antiviral effect against retroviruses. Using ectopic expression of APOBEC3A in established cell lines and specific silencing in primary macrophages and dendritic cells, we demonstrate that the pool of APOBEC3A in target cells inhibits the early phases of HIV-1 infection and the spread of replication-competent R5-tropic HIV-1, specifically in cells of myeloid origins. In these cells, APOBEC3A affects the amount of vDNA synthesized over the course of infection. The susceptibility to the antiviral effect of APOBEC3A is conserved among primate lentiviruses, although the viral protein Vpx coded by members of the SIVSM/HIV-2 lineage provides partial protection from APOBEC3A during infection. Our results indicate that APOBEC3A is a previously unrecognized antiviral factor that targets primate lentiviruses specifically in myeloid cells and that acts during the early phases of infection directly in target cells. The findings presented here open up new venues on the role of APOBEC3A during HIV infection and pathogenesis, on the role of the cellular context in the regulation of the antiviral activities of members of the APOBEC3 family and more generally on the natural functions of APOBEC3A

Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

BACKGROUND Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important following large-scale mortality spikes, such as the COVID-19 pandemic. When systematically analysed, mortality rates and life expectancy allow comparisons of the consequences of causes of death globally and over time, providing a nuanced understanding of the effect of these causes on global populations. METHODS The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 cause-of-death analysis estimated mortality and years of life lost (YLLs) from 288 causes of death by age-sex-location-year in 204 countries and territories and 811 subnational locations for each year from 1990 until 2021. The analysis used 56 604 data sources, including data from vital registration and verbal autopsy as well as surveys, censuses, surveillance systems, and cancer registries, among others. As with previous GBD rounds, cause-specific death rates for most causes were estimated using the Cause of Death Ensemble model-a modelling tool developed for GBD to assess the out-of-sample predictive validity of different statistical models and covariate permutations and combine those results to produce cause-specific mortality estimates-with alternative strategies adapted to model causes with insufficient data, substantial changes in reporting over the study period, or unusual epidemiology. YLLs were computed as the product of the number of deaths for each cause-age-sex-location-year and the standard life expectancy at each age. As part of the modelling process, uncertainty intervals (UIs) were generated using the 2·5th and 97·5th percentiles from a 1000-draw distribution for each metric. We decomposed life expectancy by cause of death, location, and year to show cause-specific effects on life expectancy from 1990 to 2021. We also used the coefficient of variation and the fraction of population affected by 90% of deaths to highlight concentrations of mortality. Findings are reported in counts and age-standardised rates. Methodological improvements for cause-of-death estimates in GBD 2021 include the expansion of under-5-years age group to include four new age groups, enhanced methods to account for stochastic variation of sparse data, and the inclusion of COVID-19 and other pandemic-related mortality-which includes excess mortality associated with the pandemic, excluding COVID-19, lower respiratory infections, measles, malaria, and pertussis. For this analysis, 199 new country-years of vital registration cause-of-death data, 5 country-years of surveillance data, 21 country-years of verbal autopsy data, and 94 country-years of other data types were added to those used in previous GBD rounds. FINDINGS The leading causes of age-standardised deaths globally were the same in 2019 as they were in 1990; in descending order, these were, ischaemic heart disease, stroke, chronic obstructive pulmonary disease, and lower respiratory infections. In 2021, however, COVID-19 replaced stroke as the second-leading age-standardised cause of death, with 94·0 deaths (95% UI 89·2-100·0) per 100 000 population. The COVID-19 pandemic shifted the rankings of the leading five causes, lowering stroke to the third-leading and chronic obstructive pulmonary disease to the fourth-leading position. In 2021, the highest age-standardised death rates from COVID-19 occurred in sub-Saharan Africa (271·0 deaths [250·1-290·7] per 100 000 population) and Latin America and the Caribbean (195·4 deaths [182·1-211·4] per 100 000 population). The lowest age-standardised death rates from COVID-19 were in the high-income super-region (48·1 deaths [47·4-48·8] per 100 000 population) and southeast Asia, east Asia, and Oceania (23·2 deaths [16·3-37·2] per 100 000 population). Globally, life expectancy steadily improved between 1990 and 2019 for 18 of the 22 investigated causes. Decomposition of global and regional life expectancy showed the positive effect that reductions in deaths from enteric infections, lower respiratory infections, stroke, and neonatal deaths, among others have contributed to improved survival over the study period. However, a net reduction of 1·6 years occurred in global life expectancy between 2019 and 2021, primarily due to increased death rates from COVID-19 and other pandemic-related mortality. Life expectancy was highly variable between super-regions over the study period, with southeast Asia, east Asia, and Oceania gaining 8·3 years (6·7-9·9) overall, while having the smallest reduction in life expectancy due to COVID-19 (0·4 years). The largest reduction in life expectancy due to COVID-19 occurred in Latin America and the Caribbean (3·6 years). Additionally, 53 of the 288 causes of death were highly concentrated in locations with less than 50% of the global population as of 2021, and these causes of death became progressively more concentrated since 1990, when only 44 causes showed this pattern. The concentration phenomenon is discussed heuristically with respect to enteric and lower respiratory infections, malaria, HIV/AIDS, neonatal disorders, tuberculosis, and measles. INTERPRETATION Long-standing gains in life expectancy and reductions in many of the leading causes of death have been disrupted by the COVID-19 pandemic, the adverse effects of which were spread unevenly among populations. Despite the pandemic, there has been continued progress in combatting several notable causes of death, leading to improved global life expectancy over the study period. Each of the seven GBD super-regions showed an overall improvement from 1990 and 2021, obscuring the negative effect in the years of the pandemic. Additionally, our findings regarding regional variation in causes of death driving increases in life expectancy hold clear policy utility. Analyses of shifting mortality trends reveal that several causes, once widespread globally, are now increasingly concentrated geographically. These changes in mortality concentration, alongside further investigation of changing risks, interventions, and relevant policy, present an important opportunity to deepen our understanding of mortality-reduction strategies. Examining patterns in mortality concentration might reveal areas where successful public health interventions have been implemented. Translating these successes to locations where certain causes of death remain entrenched can inform policies that work to improve life expectancy for people everywhere. FUNDING Bill & Melinda Gates Foundation