287 research outputs found
The Rbm38-p63 feedback loop is critical for tumor suppression and longevity.
The RNA-binding protein Rbm38 is a target of p63 tumor suppressor and can in-turn repress p63 expression via mRNA stability. Thus, Rbm38 and p63 form a negative feedback loop. To investigate the biological significance of the Rbm38-p63 loop in vivo, a cohort of WT, Rbm38-/-, TAp63+/-, and Rbm38-/-;TAp63+/- mice were generated and monitored throughout their lifespan. While mice deficient in Rbm38 or TAp63 alone died mostly from spontaneous tumors, compound Rbm38-/-;TAp63+/- mice had an extended lifespan along with reduced tumor incidence. We also found that loss-of-Rbm38 markedly decreased the percentage of liver steatosis in TAp63+/- mice. Moreover, we found that Rbm38 deficiency extends the lifespan of tumor-free TAp63+/- mice along with reduced expression of senescence-associated biomarkers. Consistent with this, Rbm38-/-;TAp63+/- MEFs were resistant, whereas Rbm38-/- or TAp63+/- MEFs were prone, to cellular senescence. Importantly, we showed that the levels of inflammatory cytokines (IL17D and Tnfsf15) were significantly reduced by Rbm38 deficiency in senescence-resistant Rbm38-/-;TAp63+/- mouse livers and MEFs. Together, our data suggest that Rbm38 and p63 function as intergenic suppressors in aging and tumorigenesis and that the Rbm38-p63 loop may be explored for enhancing longevity and cancer management
A cyber-physical machine tools platform using OPC UA and MTConnect
Cyber-Physical Machine Tools (CPMT) represent a new generation of machine tools that are smarter, well connected, widely accessible, more adaptive and more autonomous. Development of CPMT requires standardized information modelling method and communication protocols for machine tools. This paper proposes a CPMT Platform based on OPC UA and MTConnect that enables standardized, interoperable and efficient data communication among machine tools and various types of software applications. First, a development method for OPC UA-based CPMT is proposed based on a generic OPC UA information model for CNC machine tools. Second, to address the issue of interoperability between OPC UA and MTConnect, an MTConnect to OPC UA interface is developed to transform MTConnect information model and its data to their OPC UA counterparts. An OPC UA-based CPMT prototype is developed and further integrated with a previously developed MTConnect-based CPMT to establish a common CPMT Platform. Third, different applications are developed to demonstrate the advantages of the proposed CPMT Platform, including an OPC UA Client, an advanced AR-assisted wearable Human-Machine Interface and a conceptual framework for CPMT powered cloud manufacturing environment. Experimental results have proven that the proposed CPMT Platform can significantly improve the overall production efficiency and effectiveness in the shop floor
High-Resolution Deep Image Matting
Image matting is a key technique for image and video editing and composition.
Conventionally, deep learning approaches take the whole input image and an
associated trimap to infer the alpha matte using convolutional neural networks.
Such approaches set state-of-the-arts in image matting; however, they may fail
in real-world matting applications due to hardware limitations, since
real-world input images for matting are mostly of very high resolution. In this
paper, we propose HDMatt, a first deep learning based image matting approach
for high-resolution inputs. More concretely, HDMatt runs matting in a
patch-based crop-and-stitch manner for high-resolution inputs with a novel
module design to address the contextual dependency and consistency issues
between different patches. Compared with vanilla patch-based inference which
computes each patch independently, we explicitly model the cross-patch
contextual dependency with a newly-proposed Cross-Patch Contextual module (CPC)
guided by the given trimap. Extensive experiments demonstrate the effectiveness
of the proposed method and its necessity for high-resolution inputs. Our HDMatt
approach also sets new state-of-the-art performance on Adobe Image Matting and
AlphaMatting benchmarks and produce impressive visual results on more
real-world high-resolution images.Comment: AAAI 202
Learning Raw Image Denoising with Bayer Pattern Unification and Bayer Preserving Augmentation
In this paper, we present new data pre-processing and augmentation techniques
for DNN-based raw image denoising. Compared with traditional RGB image
denoising, performing this task on direct camera sensor readings presents new
challenges such as how to effectively handle various Bayer patterns from
different data sources, and subsequently how to perform valid data augmentation
with raw images. To address the first problem, we propose a Bayer pattern
unification (BayerUnify) method to unify different Bayer patterns. This allows
us to fully utilize a heterogeneous dataset to train a single denoising model
instead of training one model for each pattern. Furthermore, while it is
essential to augment the dataset to improve model generalization and
performance, we discovered that it is error-prone to modify raw images by
adapting augmentation methods designed for RGB images. Towards this end, we
present a Bayer preserving augmentation (BayerAug) method as an effective
approach for raw image augmentation. Combining these data processing technqiues
with a modified U-Net, our method achieves a PSNR of 52.11 and a SSIM of 0.9969
in NTIRE 2019 Real Image Denoising Challenge, demonstrating the
state-of-the-art performance. Our code is available at
https://github.com/Jiaming-Liu/BayerUnifyAug.Comment: Accepted by CVPRW 201
Accelerated quantum adiabatic transfer in superconducting qubits
Quantum adiabatic transfer is widely used in quantum computation and quantum
simulation. However, the transfer speed is limited by the quantum adiabatic
approximation condition, which hinders its application in quantum systems with
a short decoherence time. Here we demonstrate quantum adiabatic state transfers
that jump along geodesics in one-qubit and two-qubit superconducting transmons.
This approach possesses the advantages of speed, robustness, and high fidelity
compared with the usual adiabatic process. Our protocol provides feasible
strategies for improving state manipulation and gate operation in
superconducting quantum circuits
Dynamic Circular Network-Based Federated Dual-View Learning for Multivariate Time Series Anomaly Detection
Multivariate time-series data exhibit intricate correlations in both temporal and spatial dimensions. However, existing network architectures often overlook dependencies in the spatial dimension and struggle to strike a balance between long-term and short-term patterns when extracting features from the data. Furthermore, industries within the business community are hesitant to share their raw data, which hinders anomaly prediction accuracy and detection performance. To address these challenges, the authors propose a dynamic circular network-based federated dual-view learning approach. Experimental results from four open-source datasets demonstrate that the method outperforms existing methods in terms of accuracy, recall, and F1_score for anomaly detection
Flutter and Thermal Buckling Analysis for Composite Laminated Panel Embedded with Shape Memory Alloy Wires in Supersonic Flow
The flutter and thermal buckling behavior of laminated composite panels embedded with shape memory alloy (SMA) wires are studied in this research. The classical plate theory and nonlinear von-Karman strain-displacement relation are employed to investigate the aeroelastic behavior of the smart laminated panel. The thermodynamic behaviors of SMA wires are simulated based on one-dimensional Brinson SMA model. The aerodynamic pressure on the panel is described by the nonlinear piston theory. Nonlinear governing partial differential equations of motion are derived for the panel via the Hamilton principle. The effects of ply angle of the composite panel, SMA layer location and orientation, SMA wires temperature, volume fraction and prestrain on the buckling, flutter boundary, and amplitude of limit cycle oscillation of the panel are analyzed in detail
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