Improved bounds on the Product Rank of the Permanent

We unify Ryser's and Glynn's formulas for computing the permanent into a single framework. We then show via an orbital bound argument that the product rank of the permanent is asymptotically upper bounded by $\frac{\exp\left(\pi\sqrt{\frac{2n}{3}}\right)}{4\sqrt{3}n}$

SIRS Model of Passengers’ Panic Propagation under Self-Organization Circumstance in the Subway Emergency

Subway emergency may lead to passengers’ panic, especially under self-organizing circumstance, which will spread rapidly and have an adverse impact on the society. This paper builds an improved SIRS model of passengers’ panic spread in subway emergency with consideration of passengers’ density, the characteristic of subway car with the confined space, and passengers’ psychological factors. The spread of passengers’ panic is simulated by use of Matlab, which draws the rules of how group panic spreads dynamically. The trend of stable point of the infection ratio is analyzed by changing different parameters, which help to draw a conclusion that immunization rate, spontaneous immune loss rate, and passenger number have a great influence on the final infected ratio. Finally, we propose an integrated control strategy and find the peak of passengers’ panic and the final infected ratio is greatly improved through the numerical simulation. The research plays a vital role in helping the government and subway administration to master the panic spread mechanism and reduce the panic spread by improving measures and also provides certain reference significance for rail system construction, emergency contingency plans, and the construction and implementation of emergency response system

Petrogenesis of the ca. 80Ma felsic-intermediate magmatism in the Zhongdian arc terrane and western Yangtze block: Implications for post-collisional metallogenesis

The Relin Mo-Cu deposit and Tongchanggou Mo polymetallic deposit located in the Zhongdian arc which is the southern part of the Yidun arc of Sanjiang Tethys Region. Mineralization is closely associated with the Relin monzonitic granites and Tongchanggou granodiorite-porphyry, which were formed at 79. 0 +/- 1. 4Ma and 81. 3 +/- 1. 1Ma, respectively, according to LA-ICPMS zircon U-Pb dating. Geochemically, the Relin and Tongchanggou rocks have high SiO2 ( > 65%) and Al2O3 ( 13. 74% similar to 14. 91%) , low MgO (0. 86%similar to 1. 49% ) and Mg-#( 36. 3 similar to 47. 3) , and affinity of adakitic rocks given their high Sr (326 x 10(-6) similar to 1174 x 10(-6)) , Sr/Y (22 similar to 86) and La/Yb (30 similar to 70) ratios, and low Y (10. 2 x 10(-6) similar to 15. 6 x 10(-6)) and Yb (1. 00 x 10(-6) similar to 1. 51 x 10(-6)). These geochemical characters indicate that the Relin and Tongchanggou rocks were derived from partial melting of the thickened lower continental crust within garnet as residual minerals. Additionally, our zircon U-Pb dating reveals that the Dali granites in the western Yangtze block were formed at 76. 4 +/- 2. 3Ma, indicating that the Late Cretaceous magmatism are also developed in the western Yangtze block. We suggest that the western Yangtze block probably have the similar tectonic environment with the Zhongdian arc in the Late Cretaceous

Can 9q34.2 rs633862 polymorphism predict survival in epithelial ovarian cancer?

Objective Our previous genome-wide association study (GWAS) identified that the ABO rs633862 variant in chromosome 9q34.2 was associated with the risk of epithelial ovarian cancer (EOC) in Chinese Han women. The aim of the present study was to evaluate its prognostic effect on EOC. Methods A total of 669 EOC patients were enrolled for the genotyping of rs633862 variant in 9q34.2. We used Kaplan–Meier survival curves, univariate and multivariate Cox proportional hazard models to evaluate the association of rs633862 with overall survival (OS) in EOC patients. Results We found that rs633862 variant AG/GG genotypes were significantly associated with a longer OS by using univariate Cox proportional hazards regression analysis, compared with the rs633862 AA genotype (HR = 0.69, 95% CI [0.49–0.98], p = 0.035), albeit with a boardline significance in the multivariate analysis. Similar findings were observed in the subgroup of high-grade serous ovarian carcinoma. Further expression quantitative trait loci (eQTL) analysis indicated that the rs633862 AA genotype was associated with an increased level of ABO mRNA expression (p = 1.8 × 10−11). Conclusions Supplementary to the previous GWAS, our study provides additional evidence on the prognostic value of the 9q34.2 rs633862 variant in EOC patients, and this variant may function by regulating the ABO mRNA expression

The Antifungal Effects of Citral on <i>Magnaporthe oryzae</i> Occur via Modulation of Chitin Content as Revealed by RNA-Seq Analysis

The natural product citral has previously been demonstrated to possess antifungal activity against Magnaporthe oryzae. The purpose of this study was to screen and annotate genes that were differentially expressed (DEGs) in M. oryzae after treatment with citral using RNA sequencing (RNA-seq). Thereafter, samples were reprepared for quantitative real-time PCR (RT-qPCR) analysis verification of RNA-seq data. The results showed that 649 DEGs in M. oryzae were significantly affected after treatment with citral (100 μg/mL) for 24 h. Kyoto Encyclopedia of Genes and Genomes (KEGG) and a gene ontology (GO) analysis showed that DEGs were mainly enriched in amino sugar and nucleotide sugar metabolic pathways, including the chitin synthesis pathway and UDP sugar synthesis pathway. The results of the RT-qPCR analysis also showed that the chitin present in M. oryzae might be degraded to chitosan, chitobiose, N-acetyl-D-glucosamine, and β-D-fructose-6-phosphate following treatment with citral. Chitin degradation was indicated by damaged cell-wall integrity. Moreover, the UDP glucose synthesis pathway was involved in glycolysis and gluconeogenesis, providing precursors for the synthesis of polysaccharides. Galactose-1-phosphate uridylyltransferase, which is involved in the regulation of UDP-α-D-galactose and α-D-galactose-1-phosphate, was downregulated. This would result in the inhibition of UDP glucose (UDP-Glc) synthesis, a reduction in cell-wall glucan content, and the destruction of cell-wall integrity

Slab Breakoff of the Neo-Tethys Ocean in the Lhasa Terrane Inferred From Contemporaneous Melting of the Mantle and Crust

Oceanic slab breakoff significantly affects the thermal regime of the lithosphere during continental collision. This often triggers extension-related mafic magmatism and crustal melting. It is generally accepted that the Neo-Tethyan lithosphere subducted beneath the southern Lhasa Subterrane, resulting in the formation of the Gangdese magmatic arc. However, the timing of slab breakoff is still disputed, due to a lack of evidence for extension-related mafic magmatism. In this study, we provide comprehensive age, element and Sr-Nd-Hf isotopic data of mafic dikes, felsic intrusions, and enclaves from the Daju area, southern Lhasa Subterrane. The timing of mafic dikes and granitoids are contemporaneous at circa 57 Ma. The mafic dikes are characterized by high Th/U, and Zr/Y ratios, their geochemistry indicates an intraplate affinity rather than arc magmas. Furthermore, the mafic dikes show strongly variable igneous zircon (Hf)(t), and lower whole-rock (Nd)(t) than granitoids. This evidence suggests that the mafic dikes represent asthenosphere-derived melts contaminated by various degrees of ancient lithosphere. However, the granitoids were directly derived from the juvenile lower crust. Given the abrupt decrease in the convergence rate between India and Asia, and the surface uplift and sedimentation cessation in the southern Lhasa Subterrane in the early Cenozoic, the occurrence of synchronous mafic dikes and granitoids is best explained by a slab breakoff model. The occurrence of intraplate-type magmas likely corresponds to the magmatic expression of the initial stage of Neo-Tethyan slab breakoff. The slab breakoff concept also explains the onset of the magmatic flare-up and crustal growth after 57 Ma