SNR-Based Teachers-Student Technique for Speech Enhancement

It is very challenging for speech enhancement methods to achieves robust performance under both high signal-to-noise ratio (SNR) and low SNR simultaneously. In this paper, we propose a method that integrates an SNR-based teachers-student technique and time-domain U-Net to deal with this problem. Specifically, this method consists of multiple teacher models and a student model. We first train the teacher models under multiple small-range SNRs that do not coincide with each other so that they can perform speech enhancement well within the specific SNR range. Then, we choose different teacher models to supervise the training of the student model according to the SNR of the training data. Eventually, the student model can perform speech enhancement under both high SNR and low SNR. To evaluate the proposed method, we constructed a dataset with an SNR ranging from -20dB to 20dB based on the public dataset. We experimentally analyzed the effectiveness of the SNR-based teachers-student technique and compared the proposed method with several state-of-the-art methods.Comment: Published in 2020 IEEE International Conference on Multimedia and Expo (ICME 2020

Cross-Domain Few-Shot Classification via Inter-Source Stylization

The goal of Cross-Domain Few-Shot Classification (CDFSC) is to accurately classify a target dataset with limited labelled data by exploiting the knowledge of a richly labelled auxiliary dataset, despite the differences between the domains of the two datasets. Some existing approaches require labelled samples from multiple domains for model training. However, these methods fail when the sample labels are scarce. To overcome this challenge, this paper proposes a solution that makes use of multiple source domains without the need for additional labeling costs. Specifically, one of the source domains is completely tagged, while the others are untagged. An Inter-Source Stylization Network (ISSNet) is then introduced to enhance stylisation across multiple source domains, enriching data distribution and model's generalization capabilities. Experiments on 8 target datasets show that ISSNet leverages unlabelled data from multiple source data and significantly reduces the negative impact of domain gaps on classification performance compared to several baseline methods.Comment: 5 page

MORIN MITIGATES OXIDATIVE STRESS, APOPTOSIS AND INFLAMMATION IN CEREBRAL ISCHEMIC RATS

Background: Morin is a flavanoid which exhibits potent antioxidant activity in various oxidative stress related diseases. The current study was attempted to scrutinize the preclinical bio-efficacy of morin on focal ischemia. Methods: The animal model of focal cerebral ischemic injury was done by midbrain carotid artery occlusion (MCAO) method, followed by Morin (30mg/kg) administration for seven days. Results: The outcome of the study showed that treatment with morin displayed positive effects in reducing the focal cerebral ischemia. This effect was evident with the improvements in neurological deficits, reduction in MDA content and elevation of antioxidant levels (SOD, GSH and Gpx). Furthermore, protein expression of Bax and caspase-3 were effectively down-regulated, whilst the expression of Bcl-2 was significantly elevated. On the other hand, the mRNA expression of proinflammatory cytokines was significantly reduced in focal cerebral ischemic rats upon morin intervention. Conclusion: Thus, the beneficial effects of morin on cerebral ischemia assault may result from the reduction of oxidative stress, inhibition of apoptosis and inflammation

20(S)-Protopanaxadiol Inhibits Angiotensin II-Induced Epithelial- Mesenchymal Transition by Downregulating SIRT1

20(S)-Protopanaxadiol (PPD) is one of the major active metabolites in ginseng saponin. Our previous studies revealed a broad spectrum of antitumor effects of PPD. Angiotensin II (Ang II), the biologically active peptide of the renin-angiotensin system (RAS), plays a critical role in the metastasis of various cancers. However, its role in the anti-metastatic effects of PPD is not clearly understood. In this study, we investigated the inhibitory effect of PPD on Ang II-induced epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC) cells, and the potential molecular mechanisms of suppression of NSCLC migration and metastasis by PPD. Treatment of A549 cells with Ang II increased metastases in an experimental model of cancer metastasis in vivo. PPD effectively prevented Ang II-induced EMT, as indicated by upregulation of E-cadherin and downregulation of vimentin. Additionally, Ang II upregulated the class III deacetylase sirtuin 1 (SIRT1) expression in EMT progression, while downregulation of SIRT1 was involved in suppression of Ang II-induced EMT by PPD. Moreover, the inhibitory effect of PPD was reversed by SIRT1 upregulation, and PPD demonstrated synergy with an SIRT1 inhibitor on Ang II-induced EMT. Taken together, our data reveal the mechanism of the anti-metastatic effects of PPD on Ang II-induced EMT and indicate that PPD can be used as an effective anti-tumor treatment

Identification and Characterization of Paramyosin from Cyst Wall of Metacercariae Implicated Protective Efficacy against Clonorchis sinensis Infection

Human clonorchiasis has been increasingly prevalent in recent years and results in a threat to the public health in epidemic regions, motivating current strategies of vaccines to combat Clonorchis sinensis (C. sinensis). In this study, we identified C. sinensis paramyosin (CsPmy) from the cyst wall proteins of metacercariae by proteomic approaches and characterized the expressed recombinant pET-26b-CsPmy protein (101 kDa). Bioinformatics analysis indicated that full-length sequences of paramyosin are conserved in helminthes and numerous B-cell/T-cell epitopes were predicted in amino acid sequence of CsPmy. Western blot analysis showed that CsPmy was expressed at four life stages of C. sinensis, both cyst wall proteins and soluble tegumental components could be probed by anti-CsPmy serum. Moreover, immunolocalization results revealed that CsPmy was specifically localized at cyst wall and excretory bladder of metacercaria, as well as the tegument, oral sucker and vitellarium of adult worm. Both immunoblot and immunolocalization results demonstrated that CsPmy was highly expressed at the stage of adult worm, metacercariae and cercaria, which could be supported by real-time PCR analysis. Both recombinant protein and nucleic acid of CsPmy showed strong immunogenicity in rats and induced combined Th1/Th2 immune responses, which were reflected by continuous high level of antibody titers and increased level of IgG1/IgG2a subtypes in serum. In vaccine trials, comparing with control groups, both CsPmy protein and DNA vaccine exhibited protective effect with significant worm reduction rate of 54.3% (p<0.05) and 36.1% (p<0.05), respectively. In consistence with immune responses in sera, elevated level of cytokines IFN-γ and IL-4 in splenocytes suggested that CsPmy could induce combined cellular immunity and humoral immunity in host. Taken together, CsPmy could be a promising vaccine candidate in the prevention of C. sinensis regarding its high immunogenicity and surface localization

Hochschild cohomology rings of d-Koszul algebras

AbstractIn this paper we determine the multiplicative structure of Hochschild cohomology rings of d-Koszul algebras with the Yoneda products based on an explicit construction of a chain map Δ:P→P⊗AP lifting the identity with P a minimal projective bimodule resolution of a d-Koszul algebra A